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110 related items for PubMed ID: 15486021

  • 1. Charged residue alterations in the inner-core domain and carboxy-terminus of alpha-tropomyosin differentially affect mouse cardiac muscle contractility.
    Gaffin RD, Tong CW, Zawieja DC, Hewett TE, Klevitsky R, Robbins J, Muthuchamy M.
    J Physiol; 2004 Dec 15; 561(Pt 3):777-91. PubMed ID: 15486021
    [Abstract] [Full Text] [Related]

  • 2. Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility.
    Gaffin RD, Gokulan K, Sacchettini JC, Hewett T, Klevitsky R, Robbins J, Muthuchamy M.
    J Physiol; 2004 Apr 15; 556(Pt 2):531-43. PubMed ID: 14766940
    [Abstract] [Full Text] [Related]

  • 3. Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.
    Gaffin RD, Gokulan K, Sacchettini JC, Hewett TE, Klevitsky R, Robbins J, Sarin V, Zawieja DC, Meininger GA, Muthuchamy M.
    Am J Physiol Heart Circ Physiol; 2006 Aug 15; 291(2):H552-63. PubMed ID: 16501024
    [Abstract] [Full Text] [Related]

  • 4. Correlation between myofilament response to Ca2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express beta-tropomyosin.
    Wolska BM, Keller RS, Evans CC, Palmiter KA, Phillips RM, Muthuchamy M, Oehlenschlager J, Wieczorek DF, de Tombe PP, Solaro RJ.
    Circ Res; 1999 Apr 16; 84(7):745-51. PubMed ID: 10205142
    [Abstract] [Full Text] [Related]

  • 5. Functional importance of the carboxyl-terminal region of striated muscle tropomyosin.
    Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Vahebi S, DeTombe P, Solaro RJ, Labitzke E, Hilliard G, Wieczorek DF.
    J Biol Chem; 2003 Jun 20; 278(25):23204-11. PubMed ID: 12690096
    [Abstract] [Full Text] [Related]

  • 6. Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.
    Pieples K, Arteaga G, Solaro RJ, Grupp I, Lorenz JN, Boivin GP, Jagatheesan G, Labitzke E, DeTombe PP, Konhilas JP, Irving TC, Wieczorek DF.
    Am J Physiol Heart Circ Physiol; 2002 Oct 20; 283(4):H1344-53. PubMed ID: 12234784
    [Abstract] [Full Text] [Related]

  • 7. Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L.
    Yar S, Chowdhury SAK, Davis RT, Kobayashi M, Monasky MM, Rajan S, Wolska BM, Gaponenko V, Kobayashi T, Wieczorek DF, Solaro RJ.
    J Biol Chem; 2013 Jun 07; 288(23):16235-16246. PubMed ID: 23609439
    [Abstract] [Full Text] [Related]

  • 8. Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction.
    Muthuchamy M, Pieples K, Rethinasamy P, Hoit B, Grupp IL, Boivin GP, Wolska B, Evans C, Solaro RJ, Wieczorek DF.
    Circ Res; 1999 Jul 09; 85(1):47-56. PubMed ID: 10400910
    [Abstract] [Full Text] [Related]

  • 9. Identification of two new regions in the N-terminus of cardiac troponin T that have divergent effects on cardiac contractile function.
    Mamidi R, Mallampalli SL, Wieczorek DF, Chandra M.
    J Physiol; 2013 Mar 01; 591(5):1217-34. PubMed ID: 23207592
    [Abstract] [Full Text] [Related]

  • 10. An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.
    Jagatheesan G, Rajan S, Schulz EM, Ahmed RP, Petrashevskaya N, Schwartz A, Boivin GP, Arteaga GM, Wang T, Wang YG, Ashraf M, Liggett SB, Lorenz J, Solaro RJ, Wieczorek DF.
    Am J Physiol Heart Circ Physiol; 2009 Jul 01; 297(1):H181-90. PubMed ID: 19429821
    [Abstract] [Full Text] [Related]

  • 11. Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N.
    Gaffin RD, Chowdhury SA, Alves MS, Dias FA, Ribeiro CT, Fogaca RT, Wieczorek DF, Wolska BM.
    Am J Physiol Heart Circ Physiol; 2011 Oct 01; 301(4):H1646-55. PubMed ID: 21743000
    [Abstract] [Full Text] [Related]

  • 12. p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
    Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ.
    Circ Res; 2007 Feb 16; 100(3):408-15. PubMed ID: 17234967
    [Abstract] [Full Text] [Related]

  • 13. Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
    Karam CN, Warren CM, Rajan S, de Tombe PP, Wieczorek DF, Solaro RJ.
    J Muscle Res Cell Motil; 2011 Mar 16; 31(5-6):315-22. PubMed ID: 21221740
    [Abstract] [Full Text] [Related]

  • 14. Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity.
    Jagatheesan G, Rajan S, Ahmed RP, Petrashevskaya N, Boivin G, Arteaga GM, Tae HJ, Liggett SB, Solaro RJ, Wieczorek DF.
    J Muscle Res Cell Motil; 2010 Sep 16; 31(3):227-39. PubMed ID: 20803058
    [Abstract] [Full Text] [Related]

  • 15. Altered hemodynamics in transgenic mice harboring mutant tropomyosin linked to hypertrophic cardiomyopathy.
    Evans CC, Pena JR, Phillips RM, Muthuchamy M, Wieczorek DF, Solaro RJ, Wolska BM.
    Am J Physiol Heart Circ Physiol; 2000 Nov 16; 279(5):H2414-23. PubMed ID: 11045979
    [Abstract] [Full Text] [Related]

  • 16. PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin.
    Patel JR, Fitzsimons DP, Buck SH, Muthuchamy M, Wieczorek DF, Moss RL.
    Am J Physiol Heart Circ Physiol; 2001 Jun 16; 280(6):H2732-9. PubMed ID: 11356630
    [Abstract] [Full Text] [Related]

  • 17. Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis.
    Sheehan KA, Arteaga GM, Hinken AC, Dias FA, Ribeiro C, Wieczorek DF, Solaro RJ, Wolska BM.
    J Mol Cell Cardiol; 2011 Mar 16; 50(3):442-50. PubMed ID: 21047515
    [Abstract] [Full Text] [Related]

  • 18. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
    Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF.
    Circ Res; 2007 Jul 20; 101(2):205-14. PubMed ID: 17556658
    [Abstract] [Full Text] [Related]

  • 19. Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions.
    Wolska BM, Vijayan K, Arteaga GM, Konhilas JP, Phillips RM, Kim R, Naya T, Leiden JM, Martin AF, de Tombe PP, Solaro RJ.
    J Physiol; 2001 Nov 01; 536(Pt 3):863-70. PubMed ID: 11691878
    [Abstract] [Full Text] [Related]

  • 20. Physiological significance of troponin T binding domains in striated muscle tropomyosin.
    Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga G, de Tombe PP, Solaro RJ, Wieczorek DF.
    Am J Physiol Heart Circ Physiol; 2004 Oct 01; 287(4):H1484-94. PubMed ID: 15191887
    [Abstract] [Full Text] [Related]

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