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Journal Abstract Search

166 related items for PubMed ID: 15537364

  • 1. Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat.
    Lu JJ, Crimin K, Goodwin JT, Crivori P, Orrenius C, Xing L, Tandler PJ, Vidmar TJ, Amore BM, Wilson AG, Stouten PF, Burton PS.
    J Med Chem; 2004 Nov 18; 47(24):6104-7. PubMed ID: 15537364
    [Abstract] [Full Text] [Related]

  • 2. ADME evaluation in drug discovery. 6. Can oral bioavailability in humans be effectively predicted by simple molecular property-based rules?
    Hou T, Wang J, Zhang W, Xu X.
    J Chem Inf Model; 2007 Nov 18; 47(2):460-3. PubMed ID: 17381169
    [Abstract] [Full Text] [Related]

  • 3. The calculation of polar surface area from first principles: an application of quantum chemical topology to drug design.
    Bytheway I, Darley MG, Popelier PL.
    ChemMedChem; 2008 Mar 18; 3(3):445-53. PubMed ID: 18161739
    [Abstract] [Full Text] [Related]

  • 4. Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
    Wu C, Decker ER, Blok N, Bui H, You TJ, Wang J, Bourgoyne AR, Knowles V, Berens KL, Holland GW, Brock TA, Dixon RA.
    J Med Chem; 2004 Apr 08; 47(8):1969-86. PubMed ID: 15055997
    [Abstract] [Full Text] [Related]

  • 5. [Recent advance in predicting oral bioavailability].
    Ma GL, Cheng YY.
    Yao Xue Xue Bao; 2006 Oct 08; 41(10):917-20. PubMed ID: 17184106
    [No Abstract] [Full Text] [Related]

  • 6. Molecular properties that influence the oral bioavailability of drug candidates.
    Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD.
    J Med Chem; 2002 Jun 06; 45(12):2615-23. PubMed ID: 12036371
    [Abstract] [Full Text] [Related]

  • 7. The utility of cyclodextrins for enhancing oral bioavailability.
    Carrier RL, Miller LA, Ahmed I.
    J Control Release; 2007 Nov 06; 123(2):78-99. PubMed ID: 17888540
    [Abstract] [Full Text] [Related]

  • 8. A bioavailability score.
    Martin YC.
    J Med Chem; 2005 May 05; 48(9):3164-70. PubMed ID: 15857122
    [Abstract] [Full Text] [Related]

  • 9. Strategies to improve oral drug bioavailability.
    Gomez-Orellana I.
    Expert Opin Drug Deliv; 2005 May 05; 2(3):419-33. PubMed ID: 16296764
    [Abstract] [Full Text] [Related]

  • 10. Bioavailability of veterinary drugs in vivo and in silico.
    Grabowski T, Jaroszewski JJ.
    J Vet Pharmacol Ther; 2009 Jun 05; 32(3):249-57. PubMed ID: 19646089
    [Abstract] [Full Text] [Related]

  • 11. A timely reassessment of early prediction in the bioavailability of orally administered drugs.
    Larsen T, Link A.
    Angew Chem Int Ed Engl; 2005 Jul 18; 44(29):4432-4. PubMed ID: 15984039
    [No Abstract] [Full Text] [Related]

  • 12. The evolution of synthetic oral drug properties.
    Proudfoot JR.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1087-90. PubMed ID: 15686918
    [Abstract] [Full Text] [Related]

  • 13. Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs.
    Hu L, Tang X, Cui F.
    J Pharm Pharmacol; 2004 Dec 15; 56(12):1527-35. PubMed ID: 15563759
    [Abstract] [Full Text] [Related]

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  • 17. Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs.
    Dahan A, Hoffman A.
    J Control Release; 2008 Jul 02; 129(1):1-10. PubMed ID: 18499294
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  • 19. Hologram QSAR model for the prediction of human oral bioavailability.
    Moda TL, Montanari CA, Andricopulo AD.
    Bioorg Med Chem; 2007 Dec 15; 15(24):7738-45. PubMed ID: 17870541
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