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373 related items for PubMed ID: 15541883

  • 1. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
    Siman R, Salidas S.
    Neuroscience; 2004; 129(3):615-28. PubMed ID: 15541883
    [Abstract] [Full Text] [Related]

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  • 3. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 4. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 5. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 6. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.
    J Neurochem; 2004 Sep 01; 90(6):1402-13. PubMed ID: 15341524
    [Abstract] [Full Text] [Related]

  • 7. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation.
    Walker ES, Martinez M, Wang J, Goate A.
    J Neurochem; 2006 Jul 01; 98(1):300-9. PubMed ID: 16805816
    [Abstract] [Full Text] [Related]

  • 8. The gamma-secretase complex: machinery for intramembrane proteolysis.
    Iwatsubo T.
    Curr Opin Neurobiol; 2004 Jun 01; 14(3):379-83. PubMed ID: 15194119
    [Abstract] [Full Text] [Related]

  • 9. The role of presenilin cofactors in the gamma-secretase complex.
    Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T.
    Nature; 2003 Mar 27; 422(6930):438-41. PubMed ID: 12660785
    [Abstract] [Full Text] [Related]

  • 10. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
    Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J.
    J Neurochem; 2004 Apr 27; 89(1):44-53. PubMed ID: 15030388
    [Abstract] [Full Text] [Related]

  • 11. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.
    Nature; 2000 Jun 08; 405(6787):689-94. PubMed ID: 10864326
    [Abstract] [Full Text] [Related]

  • 12. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
    Hoke DE, Tan JL, Ilaya NT, Culvenor JG, Smith SJ, White AR, Masters CL, Evin GM.
    FEBS J; 2005 Nov 08; 272(21):5544-57. PubMed ID: 16262694
    [Abstract] [Full Text] [Related]

  • 13. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ.
    Neurobiol Dis; 2000 Dec 08; 7(6 Pt B):673-81. PubMed ID: 11114265
    [Abstract] [Full Text] [Related]

  • 14. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S, Zhou H, Walian PJ, Jap BK.
    Proc Natl Acad Sci U S A; 2005 May 24; 102(21):7499-504. PubMed ID: 15890777
    [Abstract] [Full Text] [Related]

  • 15. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J, Svensson AI, Winblad B, Karlström H, Frykman S.
    Biochem Biophys Res Commun; 2011 Jan 07; 404(1):564-8. PubMed ID: 21146496
    [Abstract] [Full Text] [Related]

  • 16. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.
    Neurobiol Dis; 2007 Feb 07; 25(2):291-6. PubMed ID: 17071095
    [Abstract] [Full Text] [Related]

  • 17. Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.
    Hébert SS, Serneels L, Dejaegere T, Horré K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B.
    Neurobiol Dis; 2004 Nov 07; 17(2):260-72. PubMed ID: 15474363
    [Abstract] [Full Text] [Related]

  • 18. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C.
    J Neurochem; 2004 Jun 07; 89(6):1520-7. PubMed ID: 15189355
    [Abstract] [Full Text] [Related]

  • 19. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
    Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A.
    J Neurochem; 2006 Jan 07; 96(1):218-27. PubMed ID: 16305624
    [Abstract] [Full Text] [Related]

  • 20. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
    Evin G, Canterford LD, Hoke DE, Sharples RA, Culvenor JG, Masters CL.
    Biochemistry; 2005 Mar 22; 44(11):4332-41. PubMed ID: 15766262
    [Abstract] [Full Text] [Related]

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