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Journal Abstract Search

245 related items for PubMed ID: 15546730

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  • 2. Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
    DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X.
    J Med Chem; 2008 Mar 27; 51(6):1681-94. PubMed ID: 18321037
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  • 10. Discovery of thienopyridines as Src-family selective Lck inhibitors.
    Abbott L, Betschmann P, Burchat A, Calderwood DJ, Davis H, Hrnciar P, Hirst GC, Li B, Morytko M, Mullen K, Yang B.
    Bioorg Med Chem Lett; 2007 Mar 01; 17(5):1167-71. PubMed ID: 17234410
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  • 11. Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck).
    Wityak J, Das J, Moquin RV, Shen Z, Lin J, Chen P, Doweyko AM, Pitt S, Pang S, Shen DR, Fang Q, de Fex HF, Schieven GL, Kanner SB, Barrish JC.
    Bioorg Med Chem Lett; 2003 Nov 17; 13(22):4007-10. PubMed ID: 14592495
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  • 12. Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
    Dalgarno D, Stehle T, Narula S, Schelling P, van Schravendijk MR, Adams S, Andrade L, Keats J, Ram M, Jin L, Grossman T, MacNeil I, Metcalf C, Shakespeare W, Wang Y, Keenan T, Sundaramoorthi R, Bohacek R, Weigele M, Sawyer T.
    Chem Biol Drug Des; 2006 Jan 17; 67(1):46-57. PubMed ID: 16492148
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  • 14. Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase.
    Goldberg DR, Butz T, Cardozo MG, Eckner RJ, Hammach A, Huang J, Jakes S, Kapadia S, Kashem M, Lukas S, Morwick TM, Panzenbeck M, Patel U, Pav S, Peet GW, Peterson JD, Prokopowicz AS, Snow RJ, Sellati R, Takahashi H, Tan J, Tschantz MA, Wang XJ, Wang Y, Wolak J, Xiong P, Moss N.
    J Med Chem; 2003 Apr 10; 46(8):1337-49. PubMed ID: 12672234
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  • 15. Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II.
    Zhang G, Ren P, Gray NS, Sim T, Wang X, Liu Y, Che J, Dong W, Tian SS, Sandberg ML, Spalding TA, Romeo R, Iskandar M, Wang Z, Seidel HM, Karanewsky DS, He Y.
    Bioorg Med Chem Lett; 2009 Dec 01; 19(23):6691-5. PubMed ID: 19854052
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  • 16. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.
    Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K, Castaneda S, Cornelius LA, Das J, Doweyko AM, Fairchild C, Hunt JT, Inigo I, Johnston K, Kamath A, Kan D, Klei H, Marathe P, Pang S, Peterson R, Pitt S, Schieven GL, Schmidt RJ, Tokarski J, Wen ML, Wityak J, Borzilleri RM.
    J Med Chem; 2004 Dec 30; 47(27):6658-61. PubMed ID: 15615512
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  • 17. Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).
    Chen P, Norris D, Iwanowicz EJ, Spergel SH, Lin J, Gu HH, Shen Z, Wityak J, Lin TA, Pang S, De Fex HF, Pitt S, Shen DR, Doweyko AM, Bassolino DA, Roberge JY, Poss MA, Chen BC, Schieven GL, Barrish JC.
    Bioorg Med Chem Lett; 2002 May 20; 12(10):1361-4. PubMed ID: 11992777
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  • 18. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).
    Sabat M, VanRens JC, Laufersweiler MJ, Brugel TA, Maier J, Golebiowski A, De B, Easwaran V, Hsieh LC, Walter RL, Mekel MJ, Evdokimov A, Janusz MJ.
    Bioorg Med Chem Lett; 2006 Dec 01; 16(23):5973-7. PubMed ID: 16997556
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  • 19. Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors.
    Das J, Moquin RV, Lin J, Liu C, Doweyko AM, DeFex HF, Fang Q, Pang S, Pitt S, Shen DR, Schieven GL, Barrish JC, Wityak J.
    Bioorg Med Chem Lett; 2003 Aug 04; 13(15):2587-90. PubMed ID: 12852972
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