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85 related items for PubMed ID: 15547247

  • 1. Nuclear localization of NADPH:cytochrome c (P450) reductase enhances the cytotoxicity of mitomycin C to Chinese hamster ovary cells.
    Seow HA, Belcourt MF, Penketh PG, Hodnick WF, Tomasz M, Rockwell S, Sartorelli AC.
    Mol Pharmacol; 2005 Feb; 67(2):417-23. PubMed ID: 15547247
    [Abstract] [Full Text] [Related]

  • 2. Activation of mitomycin C by NADPH:cytochrome P-450 reductase.
    Bligh HF, Bartoszek A, Robson CN, Hickson ID, Kasper CB, Beggs JD, Wolf CR.
    Cancer Res; 1990 Dec 15; 50(24):7789-92. PubMed ID: 2123741
    [Abstract] [Full Text] [Related]

  • 3. Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.
    Keyes SR, Fracasso PM, Heimbrook DC, Rockwell S, Sligar SG, Sartorelli AC.
    Cancer Res; 1984 Dec 15; 44(12 Pt 1):5638-43. PubMed ID: 6437671
    [Abstract] [Full Text] [Related]

  • 4. Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells.
    Fracasso PM, Sartorelli AC.
    Cancer Res; 1986 Aug 15; 46(8):3939-44. PubMed ID: 3089583
    [Abstract] [Full Text] [Related]

  • 5. Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.
    Baumann RP, Hodnick WF, Seow HA, Belcourt MF, Rockwell S, Sherman DH, Sartorelli AC.
    Cancer Res; 2001 Nov 01; 61(21):7770-6. PubMed ID: 11691791
    [Abstract] [Full Text] [Related]

  • 6. Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.
    Dulhanty AM, Whitmore GF.
    Cancer Res; 1991 Apr 01; 51(7):1860-5. PubMed ID: 1900739
    [Abstract] [Full Text] [Related]

  • 7. Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Proc Natl Acad Sci U S A; 1996 Jan 09; 93(1):456-60. PubMed ID: 8552660
    [Abstract] [Full Text] [Related]

  • 8. Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines.
    Kim SY, Rockwell S.
    Oncol Res; 1995 Jan 09; 7(5):39-47. PubMed ID: 8534933
    [Abstract] [Full Text] [Related]

  • 9. Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines.
    Rockwell S, Kim SY.
    Oncol Res; 1995 Jan 09; 7(1):39-47. PubMed ID: 7549043
    [Abstract] [Full Text] [Related]

  • 10. The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    J Biol Chem; 1998 Apr 10; 273(15):8875-81. PubMed ID: 9535868
    [Abstract] [Full Text] [Related]

  • 11. Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions.
    Seow HA, Penketh PG, Belcourt MF, Tomasz M, Rockwell S, Sartorelli AC.
    J Biol Chem; 2004 Jul 23; 279(30):31606-12. PubMed ID: 15155746
    [Abstract] [Full Text] [Related]

  • 12. Genetic variation of human cytochrome p450 reductase as a potential biomarker for mitomycin C-induced cytotoxicity.
    Wang SL, Han JF, He XY, Wang XR, Hong JY.
    Drug Metab Dispos; 2007 Jan 23; 35(1):176-9. PubMed ID: 17062779
    [Abstract] [Full Text] [Related]

  • 13. Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns.
    Bizanek R, Chowdary D, Arai H, Kasai M, Hughes CS, Sartorelli AC, Rockwell S, Tomasz M.
    Cancer Res; 1993 Nov 01; 53(21):5127-34. PubMed ID: 7693331
    [Abstract] [Full Text] [Related]

  • 14. Nuclear overexpression of NADH:cytochrome b5 reductase activity increases the cytotoxicity of mitomycin C (MC) and the total number of MC-DNA adducts in Chinese hamster ovary cells.
    Holtz KM, Rockwell S, Tomasz M, Sartorelli AC.
    J Biol Chem; 2003 Feb 14; 278(7):5029-34. PubMed ID: 12424239
    [Abstract] [Full Text] [Related]

  • 15. Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.
    Keyes SR, Rockwell S, Sartorelli AC.
    Cancer Res; 1989 Jun 15; 49(12):3310-3. PubMed ID: 2470504
    [Abstract] [Full Text] [Related]

  • 16. Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Adv Enzyme Regul; 1998 Jun 15; 38():111-33. PubMed ID: 9762350
    [Abstract] [Full Text] [Related]

  • 17. Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.
    Palom Y, Belcourt MF, Kumar GS, Arai H, Kasai M, Sartorelli AC, Rockwell S, Tomasz M.
    Oncol Res; 1998 Jun 15; 10(10):509-21. PubMed ID: 10338154
    [Abstract] [Full Text] [Related]

  • 18. Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under acidic conditions.
    Begleiter A, Leith MK.
    Mol Pharmacol; 1993 Jul 15; 44(1):210-5. PubMed ID: 8341273
    [Abstract] [Full Text] [Related]

  • 19. Modification of the cytotoxic activity of mitomycin C by oxygen and ascorbic acid in Chinese hamster ovary cells and a repair-deficient mutant.
    Marshall RS, Rauth AM.
    Cancer Res; 1986 Jun 15; 46(6):2709-13. PubMed ID: 3084075
    [Abstract] [Full Text] [Related]

  • 20. Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells.
    Marshall RS, Rauth AM.
    Cancer Res; 1988 Oct 15; 48(20):5655-9. PubMed ID: 3167822
    [Abstract] [Full Text] [Related]

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