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403 related items for PubMed ID: 15557191

  • 1. Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling.
    Hyakushima N, Mitsuzawa H, Nishitani C, Sano H, Kuronuma K, Konishi M, Himi T, Miyake K, Kuroki Y.
    J Immunol; 2004 Dec 01; 173(11):6949-54. PubMed ID: 15557191
    [Abstract] [Full Text] [Related]

  • 2. Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice.
    Mitsuzawa H, Nishitani C, Hyakushima N, Shimizu T, Sano H, Matsushima N, Fukase K, Kuroki Y.
    J Immunol; 2006 Dec 01; 177(11):8133-9. PubMed ID: 17114488
    [Abstract] [Full Text] [Related]

  • 3. The Toll-like receptor 4 region Glu24-Pro34 is critical for interaction with MD-2.
    Nishitani C, Mitsuzawa H, Hyakushima N, Sano H, Matsushima N, Kuroki Y.
    Biochem Biophys Res Commun; 2005 Mar 11; 328(2):586-90. PubMed ID: 15694388
    [Abstract] [Full Text] [Related]

  • 4. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
    Visintin A, Latz E, Monks BG, Espevik T, Golenbock DT.
    J Biol Chem; 2003 Nov 28; 278(48):48313-20. PubMed ID: 12960171
    [Abstract] [Full Text] [Related]

  • 5. MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components.
    Dziarski R, Wang Q, Miyake K, Kirschning CJ, Gupta D.
    J Immunol; 2001 Feb 01; 166(3):1938-44. PubMed ID: 11160242
    [Abstract] [Full Text] [Related]

  • 6. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide.
    Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, Arditi M.
    J Immunol; 2001 Aug 01; 167(3):1609-16. PubMed ID: 11466383
    [Abstract] [Full Text] [Related]

  • 7. Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1.
    Yang H, Young DW, Gusovsky F, Chow JC.
    J Biol Chem; 2000 Jul 07; 275(27):20861-6. PubMed ID: 10877845
    [Abstract] [Full Text] [Related]

  • 8. Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness.
    Re F, Strominger JL.
    J Immunol; 2003 Nov 15; 171(10):5272-6. PubMed ID: 14607928
    [Abstract] [Full Text] [Related]

  • 9. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.
    Bulut Y, Faure E, Thomas L, Equils O, Arditi M.
    J Immunol; 2001 Jul 15; 167(2):987-94. PubMed ID: 11441107
    [Abstract] [Full Text] [Related]

  • 10. A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4.
    Kennedy MN, Mullen GE, Leifer CA, Lee C, Mazzoni A, Dileepan KN, Segal DM.
    J Biol Chem; 2004 Aug 13; 279(33):34698-704. PubMed ID: 15175334
    [Abstract] [Full Text] [Related]

  • 11. Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
    Medvedev AE, Henneke P, Schromm A, Lien E, Ingalls R, Fenton MJ, Golenbock DT, Vogel SN.
    J Immunol; 2001 Aug 15; 167(4):2257-67. PubMed ID: 11490013
    [Abstract] [Full Text] [Related]

  • 12. MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.
    da Silva Correia J, Ulevitch RJ.
    J Biol Chem; 2002 Jan 18; 277(3):1845-54. PubMed ID: 11706042
    [Abstract] [Full Text] [Related]

  • 13. TLR2 recognizes a bacterial lipopeptide through direct binding.
    Vasselon T, Detmers PA, Charron D, Haziot A.
    J Immunol; 2004 Dec 15; 173(12):7401-5. PubMed ID: 15585865
    [Abstract] [Full Text] [Related]

  • 14. Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages.
    Akashi S, Shimazu R, Ogata H, Nagai Y, Takeda K, Kimoto M, Miyake K.
    J Immunol; 2000 Apr 01; 164(7):3471-5. PubMed ID: 10725698
    [Abstract] [Full Text] [Related]

  • 15. Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response. Importance of supratrimeric oligomerization.
    Yamada C, Sano H, Shimizu T, Mitsuzawa H, Nishitani C, Himi T, Kuroki Y.
    J Biol Chem; 2006 Aug 04; 281(31):21771-21780. PubMed ID: 16754682
    [Abstract] [Full Text] [Related]

  • 16. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.
    Akashi S, Saitoh S, Wakabayashi Y, Kikuchi T, Takamura N, Nagai Y, Kusumoto Y, Fukase K, Kusumoto S, Adachi Y, Kosugi A, Miyake K.
    J Exp Med; 2003 Oct 06; 198(7):1035-42. PubMed ID: 14517279
    [Abstract] [Full Text] [Related]

  • 17. Toll-like receptor 4-MD-2 complex mediates the signal transduction induced by flavolipin, an amino acid-containing lipid unique to Flavobacterium meningosepticum.
    Gomi K, Kawasaki K, Kawai Y, Shiozaki M, Nishijima M.
    J Immunol; 2002 Mar 15; 168(6):2939-43. PubMed ID: 11884465
    [Abstract] [Full Text] [Related]

  • 18. Overexpression of CD14, TLR4, and MD-2 in HEK 293T cells does not prevent induction of in vitro endotoxin tolerance.
    Medvedev AE, Vogel SN.
    J Endotoxin Res; 2003 Mar 15; 9(1):60-4. PubMed ID: 12691621
    [Abstract] [Full Text] [Related]

  • 19. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
    Schromm AB, Lien E, Henneke P, Chow JC, Yoshimura A, Heine H, Latz E, Monks BG, Schwartz DA, Miyake K, Golenbock DT.
    J Exp Med; 2001 Jul 02; 194(1):79-88. PubMed ID: 11435474
    [Abstract] [Full Text] [Related]

  • 20. N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide.
    Ohnishi T, Muroi M, Tanamoto K.
    J Immunol; 2001 Sep 15; 167(6):3354-9. PubMed ID: 11544325
    [Abstract] [Full Text] [Related]

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