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Journal Abstract Search

214 related items for PubMed ID: 15566303

  • 1. Time-related differences in the physical property profiles of oral drugs.
    Leeson PD, Davis AM.
    J Med Chem; 2004 Dec 02; 47(25):6338-48. PubMed ID: 15566303
    [Abstract] [Full Text] [Related]

  • 2. A comparison of physiochemical property profiles of development and marketed oral drugs.
    Wenlock MC, Austin RP, Barton P, Davis AM, Leeson PD.
    J Med Chem; 2003 Mar 27; 46(7):1250-6. PubMed ID: 12646035
    [Abstract] [Full Text] [Related]

  • 3. Characteristic physical properties and structural fragments of marketed oral drugs.
    Vieth M, Siegel MG, Higgs RE, Watson IA, Robertson DH, Savin KA, Durst GL, Hipskind PA.
    J Med Chem; 2004 Jan 01; 47(1):224-32. PubMed ID: 14695836
    [Abstract] [Full Text] [Related]

  • 4. Analysis of Physicochemical Properties for Drugs of Natural Origin.
    Camp D, Garavelas A, Campitelli M.
    J Nat Prod; 2015 Jun 26; 78(6):1370-82. PubMed ID: 26039921
    [Abstract] [Full Text] [Related]

  • 5. [Strategy of molecular design of drugs: the unification of macro-properties and micro-structures of a molecule].
    Guo ZR.
    Yao Xue Xue Bao; 2008 Mar 26; 43(3):227-33. PubMed ID: 18630256
    [Abstract] [Full Text] [Related]

  • 6. Absorption classification of oral drugs based on molecular surface properties.
    Bergström CA, Strafford M, Lazorova L, Avdeef A, Luthman K, Artursson P.
    J Med Chem; 2003 Feb 13; 46(4):558-70. PubMed ID: 12570377
    [Abstract] [Full Text] [Related]

  • 7. Escape from flatland: increasing saturation as an approach to improving clinical success.
    Lovering F, Bikker J, Humblet C.
    J Med Chem; 2009 Nov 12; 52(21):6752-6. PubMed ID: 19827778
    [Abstract] [Full Text] [Related]

  • 8. Molecular properties that influence the oral bioavailability of drug candidates.
    Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD.
    J Med Chem; 2002 Jun 06; 45(12):2615-23. PubMed ID: 12036371
    [Abstract] [Full Text] [Related]

  • 9. The evolution of synthetic oral drug properties.
    Proudfoot JR.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1087-90. PubMed ID: 15686918
    [Abstract] [Full Text] [Related]

  • 10. Polar molecular surface properties predict the intestinal absorption of drugs in humans.
    Palm K, Stenberg P, Luthman K, Artursson P.
    Pharm Res; 1997 May 15; 14(5):568-71. PubMed ID: 9165525
    [Abstract] [Full Text] [Related]

  • 11. The physicochemical challenges of designing multiple ligands.
    Morphy R, Rankovic Z.
    J Med Chem; 2006 Aug 10; 49(16):4961-70. PubMed ID: 16884308
    [Abstract] [Full Text] [Related]

  • 12. Development of specific "drug-like property" rules for carboxylate-containing oral drug candidates.
    Böcker A, Bonneau PR, Hucke O, Jakalian A, Edwards PJ.
    ChemMedChem; 2010 Dec 03; 5(12):2102-13. PubMed ID: 20979082
    [Abstract] [Full Text] [Related]

  • 13. Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.
    Leach AG, Jones HD, Cosgrove DA, Kenny PW, Ruston L, MacFaul P, Wood JM, Colclough N, Law B.
    J Med Chem; 2006 Nov 16; 49(23):6672-82. PubMed ID: 17154498
    [Abstract] [Full Text] [Related]

  • 14. Property distribution of drug-related chemical databases.
    Oprea TI.
    J Comput Aided Mol Des; 2000 Mar 16; 14(3):251-64. PubMed ID: 10756480
    [Abstract] [Full Text] [Related]

  • 15. Oral delivery of G protein-coupled receptor modulators: an explanation for the observed class difference.
    Beaumont K, Schmid E, Smith DA.
    Bioorg Med Chem Lett; 2005 Aug 15; 15(16):3658-64. PubMed ID: 15982884
    [Abstract] [Full Text] [Related]

  • 16. Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs.
    Mao F, Ni W, Xu X, Wang H, Wang J, Ji M, Li J.
    Molecules; 2016 Jan 12; 21(1):75. PubMed ID: 26771590
    [Abstract] [Full Text] [Related]

  • 17. Molecular and pharmacokinetic properties of 222 commercially available oral drugs in humans.
    Sakaeda T, Okamura N, Nagata S, Yagami T, Horinouchi M, Okumura K, Yamashita F, Hashida M.
    Biol Pharm Bull; 2001 Aug 12; 24(8):935-40. PubMed ID: 11510489
    [Abstract] [Full Text] [Related]

  • 18. Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs.
    Kelder J, Grootenhuis PD, Bayada DM, Delbressine LP, Ploemen JP.
    Pharm Res; 1999 Oct 12; 16(10):1514-9. PubMed ID: 10554091
    [Abstract] [Full Text] [Related]

  • 19. Molecular inflation, attrition and the rule of five.
    Leeson PD.
    Adv Drug Deliv Rev; 2016 Jun 01; 101():22-33. PubMed ID: 26836397
    [Abstract] [Full Text] [Related]

  • 20. Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat.
    Lu JJ, Crimin K, Goodwin JT, Crivori P, Orrenius C, Xing L, Tandler PJ, Vidmar TJ, Amore BM, Wilson AG, Stouten PF, Burton PS.
    J Med Chem; 2004 Nov 18; 47(24):6104-7. PubMed ID: 15537364
    [Abstract] [Full Text] [Related]

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