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1312 related items for PubMed ID: 15572695

  • 1. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
    Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M.
    Mol Cell Biol; 2004 Dec; 24(24):10941-53. PubMed ID: 15572695
    [Abstract] [Full Text] [Related]

  • 2. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
    Zhang DD, Lo SC, Sun Z, Habib GM, Lieberman MW, Hannink M.
    J Biol Chem; 2005 Aug 26; 280(34):30091-9. PubMed ID: 15983046
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  • 3. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
    Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.
    Mol Cell Biol; 2004 Aug 26; 24(16):7130-9. PubMed ID: 15282312
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  • 4. CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.
    Lo SC, Hannink M.
    Mol Cell Biol; 2006 Feb 26; 26(4):1235-44. PubMed ID: 16449638
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  • 5. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.
    Zhang DD, Hannink M.
    Mol Cell Biol; 2003 Nov 26; 23(22):8137-51. PubMed ID: 14585973
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  • 7. PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.
    Lo SC, Hannink M.
    J Biol Chem; 2006 Dec 08; 281(49):37893-903. PubMed ID: 17046835
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  • 9. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
    Villeneuve NF, Lau A, Zhang DD.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1699-712. PubMed ID: 20486766
    [Abstract] [Full Text] [Related]

  • 10. Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications.
    Keum YS.
    Ann N Y Acad Sci; 2011 Jul 01; 1229():184-9. PubMed ID: 21793854
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  • 11. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
    McMahon M, Itoh K, Yamamoto M, Hayes JD.
    J Biol Chem; 2003 Jun 13; 278(24):21592-600. PubMed ID: 12682069
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  • 12. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
    Sun Z, Zhang S, Chan JY, Zhang DD.
    Mol Cell Biol; 2007 Sep 13; 27(18):6334-49. PubMed ID: 17636022
    [Abstract] [Full Text] [Related]

  • 13. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.
    Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M.
    Arch Biochem Biophys; 2005 Jan 15; 433(2):342-50. PubMed ID: 15581590
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  • 15. Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.
    Kaspar JW, Niture SK, Jaiswal AK.
    J Cell Sci; 2012 Feb 15; 125(Pt 4):1027-38. PubMed ID: 22448038
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  • 17. Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.
    McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD.
    J Biol Chem; 2004 Jul 23; 279(30):31556-67. PubMed ID: 15143058
    [Abstract] [Full Text] [Related]

  • 18. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
    He X, Chen MG, Lin GX, Ma Q.
    J Biol Chem; 2006 Aug 18; 281(33):23620-31. PubMed ID: 16785233
    [Abstract] [Full Text] [Related]

  • 19. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
    Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1713-48. PubMed ID: 20446772
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