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Journal Abstract Search

316 related items for PubMed ID: 15574318

  • 1. Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability.
    Nassar AE, Kamel AM, Clarimont C.
    Drug Discov Today; 2004 Dec 01; 9(23):1020-8. PubMed ID: 15574318
    [Abstract] [Full Text] [Related]

  • 2. Improving the decision-making process in structural modification of drug candidates: reducing toxicity.
    Nassar AE, Kamel AM, Clarimont C.
    Drug Discov Today; 2004 Dec 15; 9(24):1055-64. PubMed ID: 15582794
    [Abstract] [Full Text] [Related]

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  • 5. The graphical representation of ADME-related molecule properties for medicinal chemists.
    Ritchie TJ, Ertl P, Lewis R.
    Drug Discov Today; 2011 Jan 15; 16(1-2):65-72. PubMed ID: 21074634
    [Abstract] [Full Text] [Related]

  • 6. Stability challenges in drug discovery.
    Di L, Kerns EH.
    Chem Biodivers; 2009 Nov 15; 6(11):1875-86. PubMed ID: 19937822
    [Abstract] [Full Text] [Related]

  • 7. Using in vitro human tissues to predict pharmacokinetic properties.
    Huebert ND, Dasgupta M, Chen Y.
    Curr Opin Drug Discov Devel; 2004 Jan 15; 7(1):69-74. PubMed ID: 14982150
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  • 8. Strategies for dealing with metabolite elucidation in drug discovery and development.
    Nassar AE, Talaat RE.
    Drug Discov Today; 2004 Apr 01; 9(7):317-27. PubMed ID: 15037231
    [Abstract] [Full Text] [Related]

  • 9. Strategies at the interface of drug discovery and development: early optimization of the solid state phase and preclinical toxicology formulation for potential drug candidates.
    Palucki M, Higgins JD, Kwong E, Templeton AC.
    J Med Chem; 2010 Aug 26; 53(16):5897-905. PubMed ID: 20527889
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  • 10. Application of pharmaceutical profiling assays for optimization of drug-like properties.
    Di L, Kerns EH.
    Curr Opin Drug Discov Devel; 2005 Jul 26; 8(4):495-504. PubMed ID: 16022186
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  • 11. Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery.
    Lüpfert C, Reichel A.
    Chem Biodivers; 2005 Nov 26; 2(11):1462-86. PubMed ID: 17191947
    [Abstract] [Full Text] [Related]

  • 12. Impact of hepatic uptake transporters on pharmacokinetics and drug-drug interactions: use of assays and models for decision making in the pharmaceutical industry.
    Soars MG, Webborn PJ, Riley RJ.
    Mol Pharm; 2009 Nov 26; 6(6):1662-77. PubMed ID: 19402709
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  • 13. Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
    Baillie TA.
    Chem Res Toxicol; 2008 Jan 26; 21(1):129-37. PubMed ID: 18052111
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  • 14. Structural alerts, reactive metabolites, and protein covalent binding: how reliable are these attributes as predictors of drug toxicity?
    Kalgutkar AS, Didiuk MT.
    Chem Biodivers; 2009 Nov 26; 6(11):2115-37. PubMed ID: 19937848
    [Abstract] [Full Text] [Related]

  • 15. [The role of ADME evaluation in translation research of innovative drug].
    Liu Y, Hong L, Yu LS, Jiang HD, Chen JZ, Meng Q, Chen SQ, Zeng S.
    Yao Xue Xue Bao; 2011 Jan 26; 46(1):19-29. PubMed ID: 21465804
    [Abstract] [Full Text] [Related]

  • 16. Beyond profiling: using ADMET models to guide decisions.
    Segall M, Champness E, Obrezanova O, Leeding C.
    Chem Biodivers; 2009 Nov 26; 6(11):2144-51. PubMed ID: 19937845
    [Abstract] [Full Text] [Related]

  • 17. In vitro ADME phenotyping in drug discovery: current challenges and future solutions.
    Williams JA, Bauman J, Cai H, Conlon K, Hansel S, Hurst S, Sadagopan N, Tugnait M, Zhang L, Sahi J.
    Curr Opin Drug Discov Devel; 2005 Jan 26; 8(1):78-88. PubMed ID: 15679175
    [Abstract] [Full Text] [Related]

  • 18. Formulation and manufacturability of biologics.
    Shire SJ.
    Curr Opin Biotechnol; 2009 Dec 26; 20(6):708-14. PubMed ID: 19880308
    [Abstract] [Full Text] [Related]

  • 19. Nanosuspensions in drug delivery.
    Rabinow BE.
    Nat Rev Drug Discov; 2004 Sep 26; 3(9):785-96. PubMed ID: 15340388
    [Abstract] [Full Text] [Related]

  • 20. Applicability of bioanalysis of multiple analytes in drug discovery and development: review of select case studies including assay development considerations.
    Srinivas NR.
    Biomed Chromatogr; 2006 May 26; 20(5):383-414. PubMed ID: 16307470
    [Abstract] [Full Text] [Related]

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