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563 related items for PubMed ID: 15584903

  • 1. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L, Gan L, Yu GQ, Essrich C, Mucke L.
    J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
    [Abstract] [Full Text] [Related]

  • 2. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 3. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
    [Abstract] [Full Text] [Related]

  • 4. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
    Flood F, Murphy S, Cowburn RF, Lannfelt L, Walker B, Johnston JA.
    Biochem J; 2005 Jan 15; 385(Pt 2):545-50. PubMed ID: 15473868
    [Abstract] [Full Text] [Related]

  • 5. Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.
    Ramalho RM, Borralho PM, Castro RE, Solá S, Steer CJ, Rodrigues CM.
    J Neurochem; 2006 Sep 15; 98(5):1610-8. PubMed ID: 16923170
    [Abstract] [Full Text] [Related]

  • 6. Novel alpha-secretase cleavage of Alzheimer's amyloid beta precursor protein in the endoplasmic reticulum of COS7 cells.
    Shin RW, Saido TC, Maeda M, Kitamoto T.
    Neurosci Lett; 2005 Mar 07; 376(1):14-9. PubMed ID: 15694266
    [Abstract] [Full Text] [Related]

  • 7. Mutations in APP have independent effects on Abeta and CTFgamma generation.
    Hecimovic S, Wang J, Dolios G, Martinez M, Wang R, Goate AM.
    Neurobiol Dis; 2004 Nov 07; 17(2):205-18. PubMed ID: 15474359
    [Abstract] [Full Text] [Related]

  • 8. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
    Neurosci Res; 2007 Mar 07; 57(3):446-53. PubMed ID: 17210196
    [Abstract] [Full Text] [Related]

  • 9. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ.
    Neurobiol Dis; 2000 Dec 07; 7(6 Pt B):673-81. PubMed ID: 11114265
    [Abstract] [Full Text] [Related]

  • 10. Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.
    Parvathy S, Ehrlich M, Pedrini S, Diaz N, Refolo L, Buxbaum JD, Bogush A, Petanceska S, Gandy S.
    J Neurochem; 2004 Aug 07; 90(4):1005-10. PubMed ID: 15287907
    [Abstract] [Full Text] [Related]

  • 11. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
    Irizarry MC, Deng A, Lleo A, Berezovska O, Von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW.
    J Neurochem; 2004 Sep 07; 90(5):1132-43. PubMed ID: 15312168
    [Abstract] [Full Text] [Related]

  • 12. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA.
    J Neurochem; 2006 Mar 07; 96(5):1322-35. PubMed ID: 16478525
    [Abstract] [Full Text] [Related]

  • 13. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb 07; 100(3):802-9. PubMed ID: 17156133
    [Abstract] [Full Text] [Related]

  • 14. Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway.
    Lopez-Perez E, Seidah NG, Checler F.
    J Neurochem; 1999 Nov 07; 73(5):2056-62. PubMed ID: 10537065
    [Abstract] [Full Text] [Related]

  • 15. Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway.
    Takahashi K, Niidome T, Akaike A, Kihara T, Sugimoto H.
    J Neurochem; 2009 Jun 07; 109(5):1324-37. PubMed ID: 19476545
    [Abstract] [Full Text] [Related]

  • 16. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.
    Nature; 1999 Dec 02; 402(6761):533-7. PubMed ID: 10591213
    [Abstract] [Full Text] [Related]

  • 17. Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
    Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J.
    J Alzheimers Dis; 2009 Dec 02; 16(3):565-75. PubMed ID: 19276551
    [Abstract] [Full Text] [Related]

  • 18. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S, Zhou H, Walian PJ, Jap BK.
    Proc Natl Acad Sci U S A; 2005 May 24; 102(21):7499-504. PubMed ID: 15890777
    [Abstract] [Full Text] [Related]

  • 19. Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.
    Parvathy S, Hussain I, Karran EH, Turner AJ, Hooper NM.
    Biochemistry; 1999 Jul 27; 38(30):9728-34. PubMed ID: 10423252
    [Abstract] [Full Text] [Related]

  • 20. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
    Harris B, Pereira I, Parkin E.
    Brain Res; 2009 Nov 03; 1296():203-15. PubMed ID: 19679113
    [Abstract] [Full Text] [Related]

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