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270 related items for PubMed ID: 15588166

  • 1. Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests.
    Genschow E, Spielmann H, Scholz G, Pohl I, Seiler A, Clemann N, Bremer S, Becker K.
    Altern Lab Anim; 2004 Sep; 32(3):209-44. PubMed ID: 15588166
    [Abstract] [Full Text] [Related]

  • 2. Validation of the postimplantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests.
    Piersma AH, Genschow E, Verhoef A, Spanjersberg MQ, Brown NA, Brady M, Burns A, Clemann N, Seiler A, Spielmann H.
    Altern Lab Anim; 2004 Sep; 32(3):275-307. PubMed ID: 15588168
    [Abstract] [Full Text] [Related]

  • 3. Validation of the rat limb bud micromass test in the international ECVAM validation study on three in vitro embryotoxicity tests.
    Spielmann H, Genschow E, Brown NA, Piersma AH, Verhoef A, Spanjersberg MQ, Huuskonen H, Paillard F, Seiler A.
    Altern Lab Anim; 2004 Sep; 32(3):245-74. PubMed ID: 15588167
    [Abstract] [Full Text] [Related]

  • 4. The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods.
    Genschow E, Spielmann H, Scholz G, Seiler A, Brown N, Piersma A, Brady M, Clemann N, Huuskonen H, Paillard F, Bremer S, Becker K.
    Altern Lab Anim; 2002 Sep; 30(2):151-76. PubMed ID: 11971753
    [Abstract] [Full Text] [Related]

  • 5. Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods.
    Brown NA.
    Altern Lab Anim; 2002 Sep; 30(2):177-98. PubMed ID: 11971754
    [Abstract] [Full Text] [Related]

  • 6. Lessons learned from validation of in vitro toxicity test: from failure to acceptance into regulatory practice.
    Spielmann H, Liebsch M.
    Toxicol In Vitro; 2001 Sep; 15(4-5):585-90. PubMed ID: 11566595
    [Abstract] [Full Text] [Related]

  • 7. An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds.
    Festag M, Viertel B, Steinberg P, Sehner C.
    Toxicol In Vitro; 2007 Dec; 21(8):1631-40. PubMed ID: 17719739
    [Abstract] [Full Text] [Related]

  • 8. Development of prediction models for three in vitro embryotoxicity tests in an ECVAM validation study.
    Genschow E, Scholz G, Brown N, Piersma A, Brady M, Clemann N, Huuskonen H, Paillard F, Bremer S, Becker K, Spielmann H.
    In Vitr Mol Toxicol; 2000 Dec; 13(1):51-66. PubMed ID: 10900407
    [Abstract] [Full Text] [Related]

  • 9. Trends in improving the embryonic stem cell test (EST): an overview.
    Buesen R, Visan A, Genschow E, Slawik B, Spielmann H, Seiler A.
    ALTEX; 2004 Dec; 21(1):15-22. PubMed ID: 14976585
    [Abstract] [Full Text] [Related]

  • 10. Assaying embryotoxicity in the test tube: current limitations of the embryonic stem cell test (EST) challenging its applicability domain.
    Riebeling C, Hayess K, Peters AK, Steemans M, Spielmann H, Luch A, Seiler AE.
    Crit Rev Toxicol; 2012 May; 42(5):443-64. PubMed ID: 22512667
    [Abstract] [Full Text] [Related]

  • 11. Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design.
    Thomson J, Johnson K, Chapin R, Stedman D, Kumpf S, Ozolinš TR.
    Birth Defects Res B Dev Reprod Toxicol; 2011 Apr; 92(2):111-21. PubMed ID: 21370399
    [Abstract] [Full Text] [Related]

  • 12. Validation successes: chemicals.
    Spielmann H, Liebsch M.
    Altern Lab Anim; 2002 Dec; 30 Suppl 2():33-40. PubMed ID: 12513649
    [Abstract] [Full Text] [Related]

  • 13. Development of a testing strategy for detecting embryotoxic hazards of chemicals in vitro by using embryonic stem cell models.
    Bremer S, Pellizzer C, Adler S, Paparella M, de Lange J.
    Altern Lab Anim; 2002 Dec; 30 Suppl 2():107-9. PubMed ID: 12513659
    [Abstract] [Full Text] [Related]

  • 14. Individual and combined developmental toxicity assessment of bisphenol A and genistein using the embryonic stem cell test in vitro.
    Kong D, Xing L, Liu R, Jiang J, Wang W, Shang L, Wei X, Hao W.
    Food Chem Toxicol; 2013 Oct; 60():497-505. PubMed ID: 23948354
    [Abstract] [Full Text] [Related]

  • 15. Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines.
    Li L, Yin Tang L, Liang B, Wang R, Sun Q, Bik San Lau C, Chung Leung P, Fritsche E, Liebsch M, Seiler Wulczyn AEM, Spielmann H, Wang CC.
    Reprod Toxicol; 2019 Oct; 89():45-53. PubMed ID: 31228572
    [Abstract] [Full Text] [Related]

  • 16. Preliminary results of the ECVAM validation study on three in vitro embryotoxicity tests.
    Spielmann H, Genschow E, Scholz G, Brown NA, Piersma AH, Brady M, Clemann N, Huuskonen H, Paillard F, Bremer S, Becker K.
    Altern Lab Anim; 2001 Oct; 29(3):301-3. PubMed ID: 11430311
    [No Abstract] [Full Text] [Related]

  • 17. Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling.
    Verwei M, van Burgsteden JA, Krul CA, van de Sandt JJ, Freidig AP.
    Toxicol Lett; 2006 Aug 01; 165(1):79-87. PubMed ID: 16517103
    [Abstract] [Full Text] [Related]

  • 18. Results of the first phase of the ECVAM project "prevalidation and validation of three in vitro embryotoxicity tests".
    Scholz G, Pohl I, Seiler A, Bremer S, Brown NA, Piersma AH, Holzhütter HG, Spielmann H.
    ALTEX; 1998 Aug 01; 15(1):3-8. PubMed ID: 11208261
    [Abstract] [Full Text] [Related]

  • 19. [Development of prediction models for three in vitro embryotoxicity tests which are evaluated in an ECVAM validation study].
    Genschow E, Scholz G, Brown NA, Piersma AH, Brady M, Clemann N, Huuskonen H, Paillard F, Bremer S, Spielmann H.
    ALTEX; 1999 Aug 01; 16(2):73-83. PubMed ID: 11107310
    [Abstract] [Full Text] [Related]

  • 20. Embryotoxic potential of N-methyl-pyrrolidone (NMP) and three of its metabolites using the rat whole embryo culture system.
    Flick B, Talsness CE, Jäckh R, Buesen R, Klug S.
    Toxicol Appl Pharmacol; 2009 Jun 01; 237(2):154-67. PubMed ID: 19281833
    [Abstract] [Full Text] [Related]

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