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704 related items for PubMed ID: 15601837

  • 1. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.
    Fukuhara S, Sakurai A, Sano H, Yamagishi A, Somekawa S, Takakura N, Saito Y, Kangawa K, Mochizuki N.
    Mol Cell Biol; 2005 Jan; 25(1):136-46. PubMed ID: 15601837
    [Abstract] [Full Text] [Related]

  • 2. Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells.
    Noda K, Zhang J, Fukuhara S, Kunimoto S, Yoshimura M, Mochizuki N.
    Mol Biol Cell; 2010 Feb 15; 21(4):584-96. PubMed ID: 20032304
    [Abstract] [Full Text] [Related]

  • 3. Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.
    Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL.
    J Cell Biol; 2003 Feb 17; 160(4):487-93. PubMed ID: 12578910
    [Abstract] [Full Text] [Related]

  • 4. Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1.
    Birukova AA, Meng F, Tian Y, Meliton A, Sarich N, Quilliam LA, Birukov KG.
    Biochim Biophys Acta; 2015 May 17; 1852(5):778-91. PubMed ID: 25545047
    [Abstract] [Full Text] [Related]

  • 5. Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery.
    Adamson RH, Ly JC, Sarai RK, Lenz JF, Altangerel A, Drenckhahn D, Curry FE.
    Am J Physiol Heart Circ Physiol; 2008 Mar 17; 294(3):H1188-96. PubMed ID: 18178724
    [Abstract] [Full Text] [Related]

  • 6. Epac1 regulates integrity of endothelial cell junctions through VE-cadherin.
    Kooistra MR, Corada M, Dejana E, Bos JL.
    FEBS Lett; 2005 Sep 12; 579(22):4966-72. PubMed ID: 16115630
    [Abstract] [Full Text] [Related]

  • 7. Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation.
    Birukova AA, Zagranichnaya T, Fu P, Alekseeva E, Chen W, Jacobson JR, Birukov KG.
    Exp Cell Res; 2007 Jul 01; 313(11):2504-20. PubMed ID: 17493609
    [Abstract] [Full Text] [Related]

  • 8. MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion.
    Sakurai A, Fukuhara S, Yamagishi A, Sako K, Kamioka Y, Masuda M, Nakaoka Y, Mochizuki N.
    Mol Biol Cell; 2006 Feb 01; 17(2):966-76. PubMed ID: 16339077
    [Abstract] [Full Text] [Related]

  • 9. Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.
    Li J, O'Connor KL, Cheng X, Mei FC, Uchida T, Townsend CM, Evers BM.
    Mol Endocrinol; 2007 Jan 01; 21(1):159-71. PubMed ID: 17068197
    [Abstract] [Full Text] [Related]

  • 10. [Signaling mechanism involved in regulation of endothelial cell-cell junctions].
    Fukuhara S, Mochizuki N.
    Yakugaku Zasshi; 2010 Nov 01; 130(11):1413-20. PubMed ID: 21048397
    [Abstract] [Full Text] [Related]

  • 11. Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP.
    Birukova AA, Burdette D, Moldobaeva N, Xing J, Fu P, Birukov KG.
    Microvasc Res; 2010 Mar 01; 79(2):128-38. PubMed ID: 19962392
    [Abstract] [Full Text] [Related]

  • 12. Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes.
    Somekawa S, Fukuhara S, Nakaoka Y, Fujita H, Saito Y, Mochizuki N.
    Circ Res; 2005 Sep 30; 97(7):655-62. PubMed ID: 16123333
    [Abstract] [Full Text] [Related]

  • 13. Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
    Misra UK, Pizzo SV.
    J Biol Chem; 2005 Nov 18; 280(46):38276-89. PubMed ID: 16172130
    [Abstract] [Full Text] [Related]

  • 14. CAMP activates Rap1 in differentiating mouse male germ cells: a new signaling pathway mediated by the cAMP-activated exchange factor Epac?
    Berruti G.
    Cell Mol Biol (Noisy-le-grand); 2003 May 18; 49(3):381-8. PubMed ID: 12887090
    [Abstract] [Full Text] [Related]

  • 15. Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability.
    Rampersad SN, Ovens JD, Huston E, Umana MB, Wilson LS, Netherton SJ, Lynch MJ, Baillie GS, Houslay MD, Maurice DH.
    J Biol Chem; 2010 Oct 29; 285(44):33614-22. PubMed ID: 20732872
    [Abstract] [Full Text] [Related]

  • 16. Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice.
    Yamamoto K, Watanabe-Takano H, Oguri-Nakamura E, Matsuno H, Horikami D, Ishii T, Ohashi R, Kubota Y, Nishiyama K, Murata T, Mochizuki N, Fukuhara S.
    FASEB J; 2023 Dec 29; 37(12):e23310. PubMed ID: 38010922
    [Abstract] [Full Text] [Related]

  • 17. Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU.
    Murphy MM, Zayed MA, Evans A, Parker CE, Ataga KI, Telen MJ, Parise LV.
    Blood; 2005 Apr 15; 105(8):3322-9. PubMed ID: 15613546
    [Abstract] [Full Text] [Related]

  • 18. A novel approach to prevent endothelial hyperpermeability: the Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway.
    Bubik MF, Willer EA, Bihari P, Jürgenliemk G, Ammer H, Krombach F, Zahler S, Vollmar AM, Fürst R.
    J Mol Cell Cardiol; 2012 Jan 15; 52(1):196-205. PubMed ID: 22085704
    [Abstract] [Full Text] [Related]

  • 19. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
    de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL.
    Nature; 1998 Dec 03; 396(6710):474-7. PubMed ID: 9853756
    [Abstract] [Full Text] [Related]

  • 20. Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function.
    Sehrawat S, Cullere X, Patel S, Italiano J, Mayadas TN.
    Mol Biol Cell; 2008 Mar 03; 19(3):1261-70. PubMed ID: 18172027
    [Abstract] [Full Text] [Related]

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