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Journal Abstract Search

165 related items for PubMed ID: 15603957

  • 1. A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.
    Lewis SJ, Smith AL, Neduvelil JG, Stevenson GI, Lindon MJ, Jones AB, Shearman MS, Beher D, Clarke E, Best JD, Peachey JE, Harrison T, Castro JL.
    Bioorg Med Chem Lett; 2005 Jan 17; 15(2):373-8. PubMed ID: 15603957
    [Abstract] [Full Text] [Related]

  • 2. Cyclic sulfamide gamma-secretase inhibitors.
    Sparey T, Beher D, Best J, Biba M, Castro JL, Clarke E, Hannam J, Harrison T, Lewis H, Madin A, Shearman M, Sohal B, Tsou N, Welch C, Wrigley J.
    Bioorg Med Chem Lett; 2005 Oct 01; 15(19):4212-6. PubMed ID: 16054361
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  • 3. 2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of gamma-secretase.
    Prasad CV, Vig S, Smith DW, Gao Q, Polson CT, Corsa JA, Guss VL, Loo A, Barten DM, Zheng M, Felsenstein KM, Roberts SB.
    Bioorg Med Chem Lett; 2004 Jul 05; 14(13):3535-8. PubMed ID: 15177468
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  • 4. Hydroxytriamides as potent gamma-secretase inhibitors.
    Prasad CV, Wallace OB, Noonan JW, Sloan CP, Lau W, Vig S, Parker MF, Smith DW, Hansel SB, Polson CT, Barten DM, Felsenstein KM, Roberts SB.
    Bioorg Med Chem Lett; 2004 Apr 19; 14(8):1917-21. PubMed ID: 15050627
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  • 5. 3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
    Shaw D, Best J, Dinnell K, Nadin A, Shearman M, Pattison C, Peachey J, Reilly M, Williams B, Wrigley J, Harrison T.
    Bioorg Med Chem Lett; 2006 Jun 01; 16(11):3073-7. PubMed ID: 16617016
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  • 6. Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors.
    Gundersen E, Fan K, Haas K, Huryn D, Steven Jacobsen J, Kreft A, Martone R, Mayer S, Sonnenberg-Reines J, Sun SC, Zhou H.
    Bioorg Med Chem Lett; 2005 Apr 01; 15(7):1891-4. PubMed ID: 15780628
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  • 7. Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.
    Pollack SJ, Lewis H.
    Curr Opin Investig Drugs; 2005 Jan 01; 6(1):35-47. PubMed ID: 15675602
    [Abstract] [Full Text] [Related]

  • 8. Conformationally biased P3 amide replacements of beta-secretase inhibitors.
    Stachel SJ, Coburn CA, Steele TG, Crouthamel MC, Pietrak BL, Lai MT, Holloway MK, Munshi SK, Graham SL, Vacca JP.
    Bioorg Med Chem Lett; 2006 Feb 01; 16(3):641-4. PubMed ID: 16263281
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  • 9. Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.
    Keown LE, Collins I, Cooper LC, Harrison T, Madin A, Mistry J, Reilly M, Shaimi M, Welch CJ, Clarke EE, Lewis HD, Wrigley JD, Best JD, Murray F, Shearman MS.
    J Med Chem; 2009 Jun 11; 52(11):3441-4. PubMed ID: 19432431
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  • 12. 3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
    Jelley RA, Elliott J, Gibson KR, Harrison T, Beher D, Clarke EE, Lewis HD, Shearman M, Wrigley JD.
    Bioorg Med Chem Lett; 2006 Jul 15; 16(14):3839-42. PubMed ID: 16682202
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  • 13. Recent advances in the development of gamma-secretase inhibitors.
    Josien H.
    Curr Opin Drug Discov Devel; 2002 Jul 15; 5(4):513-25. PubMed ID: 12197309
    [Abstract] [Full Text] [Related]

  • 14. Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide].
    Best JD, Jay MT, Otu F, Ma J, Nadin A, Ellis S, Lewis HD, Pattison C, Reilly M, Harrison T, Shearman MS, Williamson TL, Atack JR.
    J Pharmacol Exp Ther; 2005 May 15; 313(2):902-8. PubMed ID: 15743924
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  • 19. Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
    Bergstrom CP, Sloan CP, Lau WY, Smith DW, Zheng M, Hansel SB, Polson CT, Corsa JA, Barten DM, Felsenstein KM, Roberts SB.
    Bioorg Med Chem Lett; 2008 Jan 15; 18(2):464-8. PubMed ID: 18178084
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  • 20. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
    Lindsley SR, Moore KP, Rajapakse HA, Selnick HG, Young MB, Zhu H, Munshi S, Kuo L, McGaughey GB, Colussi D, Crouthamel MC, Lai MT, Pietrak B, Price EA, Sankaranarayanan S, Simon AJ, Seabrook GR, Hazuda DJ, Pudvah NT, Hochman JH, Graham SL, Vacca JP, Nantermet PG.
    Bioorg Med Chem Lett; 2007 Jul 15; 17(14):4057-61. PubMed ID: 17482814
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