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Journal Abstract Search

220 related items for PubMed ID: 15608354

  • 1. Prediction of in vitro intrinsic clearance from hepatocytes: comparison of suspensions and monolayer cultures.
    Griffin SJ, Houston JB.
    Drug Metab Dispos; 2005 Jan; 33(1):115-20. PubMed ID: 15608354
    [Abstract] [Full Text] [Related]

  • 2. Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance.
    Griffin SJ, Houston JB.
    Drug Metab Dispos; 2004 May; 32(5):552-8. PubMed ID: 15100178
    [Abstract] [Full Text] [Related]

  • 3. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.
    Brown HS, Griffin M, Houston JB.
    Drug Metab Dispos; 2007 Feb; 35(2):293-301. PubMed ID: 17132764
    [Abstract] [Full Text] [Related]

  • 4. Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.
    Donato MT, Hallifax D, Picazo L, Castell JV, Houston JB, Gomez-Lechón MJ, Lahoz A.
    Drug Metab Dispos; 2010 Sep; 38(9):1449-55. PubMed ID: 20501911
    [Abstract] [Full Text] [Related]

  • 5. Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Zanelli U, Caradonna NP, Hallifax D, Turlizzi E, Houston JB.
    Drug Metab Dispos; 2012 Jan; 40(1):104-10. PubMed ID: 21998403
    [Abstract] [Full Text] [Related]

  • 6. Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations.
    Jones HM, Houston JB.
    Drug Metab Dispos; 2004 Sep; 32(9):973-82. PubMed ID: 15319339
    [Abstract] [Full Text] [Related]

  • 7. Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes.
    Floby E, Johansson J, Hoogstraate J, Hewitt NJ, Hill J, Sohlenius-Sternbeck AK.
    Xenobiotica; 2009 Sep; 39(9):656-62. PubMed ID: 19622023
    [Abstract] [Full Text] [Related]

  • 8. Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance.
    Foster JA, Houston JB, Hallifax D.
    Xenobiotica; 2011 Feb; 41(2):124-36. PubMed ID: 21058916
    [Abstract] [Full Text] [Related]

  • 9. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.
    Riley RJ, McGinnity DF, Austin RP.
    Drug Metab Dispos; 2005 Sep; 33(9):1304-11. PubMed ID: 15932954
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  • 12. The suitability of hepatocyte culture models to study various aspects of drug metabolism.
    Nussler AK, Wang A, Neuhaus P, Fischer J, Yuan J, Liu L, Zeilinger K, Gerlach J, Arnold PJ, Albrecht W.
    ALTEX; 2001 Sep; 18(2):91-101. PubMed ID: 11378681
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  • 13. Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds.
    Sohlenius-Sternbeck AK, Afzelius L, Prusis P, Neelissen J, Hoogstraate J, Johansson J, Floby E, Bengtsson A, Gissberg O, Sternbeck J, Petersson C.
    Xenobiotica; 2010 Sep; 40(9):637-49. PubMed ID: 20624033
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  • 14. The use of sandwich-cultured rat hepatocytes to determine the intrinsic clearance of compounds with different extraction ratios: 7-ethoxycoumarin and warfarin.
    Treijtel N, van Helvoort H, Barendregt A, Blaauboer BJ, van Eijkeren JC.
    Drug Metab Dispos; 2005 Sep; 33(9):1325-32. PubMed ID: 15951450
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  • 16. Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.
    Fagerholm U.
    J Pharm Pharmacol; 2007 Jun; 59(6):803-28. PubMed ID: 17637173
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  • 18. Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes.
    Blanchard N, Richert L, Notter B, Delobel F, David P, Coassolo P, Lavé T.
    Eur J Pharm Sci; 2004 Oct; 23(2):189-99. PubMed ID: 15451007
    [Abstract] [Full Text] [Related]

  • 19. Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG.
    Bonn B, Svanberg P, Janefeldt A, Hultman Ia, Grime K.
    Drug Metab Dispos; 2016 Apr; 44(4):527-33. PubMed ID: 26851239
    [Abstract] [Full Text] [Related]

  • 20. Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance.
    McGinnity DF, Soars MG, Urbanowicz RA, Riley RJ.
    Drug Metab Dispos; 2004 Nov; 32(11):1247-53. PubMed ID: 15286053
    [Abstract] [Full Text] [Related]

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