These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

241 related items for PubMed ID: 15640374

  • 1. Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes.
    Yu LJ, Chen Y, Deninno MP, O'Connell TN, Hop CE.
    Drug Metab Dispos; 2005 Apr; 33(4):484-8. PubMed ID: 15640374
    [Abstract] [Full Text] [Related]

  • 2. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
    Boerma JS, Vermeulen NP, Commandeur JN.
    Chem Biol Interact; 2014 Jan 25; 207():32-40. PubMed ID: 24246759
    [Abstract] [Full Text] [Related]

  • 3. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.
    Drug Metab Dispos; 1999 Mar 25; 27(3):365-72. PubMed ID: 10064567
    [Abstract] [Full Text] [Related]

  • 4. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W, Stearns RA, Wang RW, Chiu SH, Baillie TA.
    Chem Res Toxicol; 1999 Feb 25; 12(2):192-9. PubMed ID: 10027798
    [Abstract] [Full Text] [Related]

  • 5. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
    Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.
    Chem Res Toxicol; 1999 Feb 25; 12(2):214-22. PubMed ID: 10027801
    [Abstract] [Full Text] [Related]

  • 6. Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
    Dragovic S, Boerma JS, Vermeulen NP, Commandeur JN.
    Chem Res Toxicol; 2013 Nov 18; 26(11):1632-41. PubMed ID: 24083800
    [Abstract] [Full Text] [Related]

  • 7. Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition.
    Yan Z, Caldwell GW, Maher N.
    Anal Chem; 2008 Aug 15; 80(16):6410-22. PubMed ID: 18642850
    [Abstract] [Full Text] [Related]

  • 8. Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1.
    Boerma JS, Dragovic S, Vermeulen NP, Commandeur JN.
    Chem Res Toxicol; 2012 Nov 19; 25(11):2532-41. PubMed ID: 22998212
    [Abstract] [Full Text] [Related]

  • 9. Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes.
    Grillo MP, Hua F, Knutson CG, Ware JA, Li C.
    Chem Res Toxicol; 2003 Nov 19; 16(11):1410-7. PubMed ID: 14615966
    [Abstract] [Full Text] [Related]

  • 10. Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid.
    Miyamoto G, Zahid N, Uetrecht JP.
    Chem Res Toxicol; 1997 Apr 19; 10(4):414-9. PubMed ID: 9114978
    [Abstract] [Full Text] [Related]

  • 11. Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine.
    Wen B, Ma L, Rodrigues AD, Zhu M.
    Drug Metab Dispos; 2008 May 19; 36(5):841-50. PubMed ID: 18238857
    [Abstract] [Full Text] [Related]

  • 12. Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadruple linear ion trap mass spectrometry.
    Zheng J, Ma L, Xin B, Olah T, Humphreys WG, Zhu M.
    Chem Res Toxicol; 2007 May 19; 20(5):757-66. PubMed ID: 17402749
    [Abstract] [Full Text] [Related]

  • 13. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.
    Chem Res Toxicol; 2007 Jan 19; 20(1):140-8. PubMed ID: 17226936
    [Abstract] [Full Text] [Related]

  • 14. Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.
    Zhu M, Ma L, Zhang H, Humphreys WG.
    Anal Chem; 2007 Nov 01; 79(21):8333-41. PubMed ID: 17918967
    [Abstract] [Full Text] [Related]

  • 15. An algorithm for thorough background subtraction from high-resolution LC/MS data: application for detection of glutathione-trapped reactive metabolites.
    Zhang H, Yang Y.
    J Mass Spectrom; 2008 Sep 01; 43(9):1181-90. PubMed ID: 18300330
    [Abstract] [Full Text] [Related]

  • 16. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W.
    Drug Metab Dispos; 2006 Jan 01; 34(1):145-51. PubMed ID: 16251255
    [Abstract] [Full Text] [Related]

  • 17. Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.
    Madsen KG, Skonberg C, Jurva U, Cornett C, Hansen SH, Johansen TN, Olsen J.
    Chem Res Toxicol; 2008 May 01; 21(5):1107-19. PubMed ID: 18419141
    [Abstract] [Full Text] [Related]

  • 18.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 19.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 20. A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues.
    Soglia JR, Contillo LG, Kalgutkar AS, Zhao S, Hop CE, Boyd JG, Cole MJ.
    Chem Res Toxicol; 2006 Mar 01; 19(3):480-90. PubMed ID: 16544956
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 13.