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Journal Abstract Search

265 related items for PubMed ID: 15643424

  • 1. Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.
    Xu W, Yuan X, Xiang Z, Mimnaugh E, Marcu M, Neckers L.
    Nat Struct Mol Biol; 2005 Feb; 12(2):120-6. PubMed ID: 15643424
    [Abstract] [Full Text] [Related]

  • 2. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity.
    Sumanasekera WK, Tien ES, Davis JW, Turpey R, Perdew GH, Vanden Heuvel JP.
    Biochemistry; 2003 Sep 16; 42(36):10726-35. PubMed ID: 12962497
    [Abstract] [Full Text] [Related]

  • 3. Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2.
    Pedersen NM, Breen K, Rødland MS, Haslekås C, Stang E, Madshus IH.
    Mol Cancer Res; 2009 Feb 16; 7(2):275-84. PubMed ID: 19208749
    [Abstract] [Full Text] [Related]

  • 4. Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.
    Onuoha SC, Mukund SR, Coulstock ET, Sengerovà B, Shaw J, McLaughlin SH, Jackson SE.
    J Mol Biol; 2007 Sep 14; 372(2):287-97. PubMed ID: 17662999
    [Abstract] [Full Text] [Related]

  • 5. A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.
    Itoh H, Ogura M, Komatsuda A, Wakui H, Miura AB, Tashima Y.
    Biochem J; 1999 Nov 01; 343 Pt 3(Pt 3):697-703. PubMed ID: 10527951
    [Abstract] [Full Text] [Related]

  • 6. Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90.
    Xu W, Mimnaugh E, Rosser MF, Nicchitta C, Marcu M, Yarden Y, Neckers L.
    J Biol Chem; 2001 Feb 02; 276(5):3702-8. PubMed ID: 11071886
    [Abstract] [Full Text] [Related]

  • 7. The Ah receptor is a sensitive target of geldanamycin-induced protein turnover.
    Chen HS, Singh SS, Perdew GH.
    Arch Biochem Biophys; 1997 Dec 01; 348(1):190-8. PubMed ID: 9390191
    [Abstract] [Full Text] [Related]

  • 8. Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells.
    Xu W, Yu F, Yan M, Lu L, Zou W, Sun L, Zheng Z, Liu X.
    J Cell Physiol; 2004 Feb 01; 198(2):188-96. PubMed ID: 14603521
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.
    Le Brazidec JY, Kamal A, Busch D, Thao L, Zhang L, Timony G, Grecko R, Trent K, Lough R, Salazar T, Khan S, Burrows F, Boehm MF.
    J Med Chem; 2004 Jul 15; 47(15):3865-73. PubMed ID: 15239664
    [Abstract] [Full Text] [Related]

  • 10. Heat shock protein 90 and ErbB2 in the cardiac response to doxorubicin injury.
    Gabrielson K, Bedja D, Pin S, Tsao A, Gama L, Yuan B, Muratore N.
    Cancer Res; 2007 Feb 15; 67(4):1436-41. PubMed ID: 17308081
    [Abstract] [Full Text] [Related]

  • 11. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors.
    Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, Burrows FJ.
    Nature; 2003 Sep 25; 425(6956):407-10. PubMed ID: 14508491
    [Abstract] [Full Text] [Related]

  • 12. Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
    Smith V, Sausville EA, Camalier RF, Fiebig HH, Burger AM.
    Cancer Chemother Pharmacol; 2005 Aug 25; 56(2):126-37. PubMed ID: 15841378
    [Abstract] [Full Text] [Related]

  • 13. Inside the Hsp90 inhibitors binding mode through induced fit docking.
    Lauria A, Ippolito M, Almerico AM.
    J Mol Graph Model; 2009 Feb 25; 27(6):712-22. PubMed ID: 19084447
    [Abstract] [Full Text] [Related]

  • 14. Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37.
    Nony P, Gaude H, Rossel M, Fournier L, Rouault JP, Billaud M.
    Oncogene; 2003 Dec 11; 22(57):9165-75. PubMed ID: 14668798
    [Abstract] [Full Text] [Related]

  • 15. Geldanamycin prevents nuclear translocation of mutant p53.
    Dasgupta G, Momand J.
    Exp Cell Res; 1997 Nov 25; 237(1):29-37. PubMed ID: 9417863
    [Abstract] [Full Text] [Related]

  • 16. Geldanamycin-induced PCNA degradation in isolated Hsp90 complex from cancer cells.
    Wang X, Heuvelman DM, Carroll JA, Dufield DR, Masferrer JL.
    Cancer Invest; 2010 Jul 25; 28(6):635-41. PubMed ID: 20394503
    [Abstract] [Full Text] [Related]

  • 17. Cdk2: a genuine protein kinase client of Hsp90 and Cdc37.
    Prince T, Sun L, Matts RL.
    Biochemistry; 2005 Nov 22; 44(46):15287-95. PubMed ID: 16285732
    [Abstract] [Full Text] [Related]

  • 18. The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.
    Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR.
    Oncogene; 2009 Nov 19; 28(46):4075-94. PubMed ID: 19734938
    [Abstract] [Full Text] [Related]

  • 19. Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates.
    Hartson SD, Thulasiraman V, Huang W, Whitesell L, Matts RL.
    Biochemistry; 1999 Mar 23; 38(12):3837-49. PubMed ID: 10090774
    [Abstract] [Full Text] [Related]

  • 20. MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90.
    Ren J, Bharti A, Raina D, Chen W, Ahmad R, Kufe D.
    Oncogene; 2006 Jan 05; 25(1):20-31. PubMed ID: 16158055
    [Abstract] [Full Text] [Related]

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