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235 related items for PubMed ID: 15652362

  • 1. Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
    Cusan C, Spalluto G, Prato M, Adams M, Bodensieck A, Bauer R, Tubaro A, Bernardi P, Da Ros T.
    Farmaco; 2005 Jan; 60(1):7-13. PubMed ID: 15652362
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
    Cusan C, Spalluto G, Prato M, Adams M, Bodensieck A, Bauer R, Tubaro A, Bernardi P, Da Ros T.
    Farmaco; 2005 Apr; 60(4):327-32. PubMed ID: 15848208
    [Abstract] [Full Text] [Related]

  • 3. Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
    Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6138-41. PubMed ID: 18945614
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7898-909. PubMed ID: 16904331
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
    Rao PN, Chen QH, Knaus EE.
    J Med Chem; 2006 Mar 09; 49(5):1668-83. PubMed ID: 16509583
    [Abstract] [Full Text] [Related]

  • 6. Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
    Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE.
    J Med Chem; 2009 Mar 26; 52(6):1525-9. PubMed ID: 19296694
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
    Reddy MV, Billa VK, Pallela VR, Mallireddigari MR, Boominathan R, Gabriel JL, Reddy EP.
    Bioorg Med Chem; 2008 Apr 01; 16(7):3907-16. PubMed ID: 18272371
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases.
    Moreau A, Chen QH, Praveen Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7716-27. PubMed ID: 16931030
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biological evaluation of acyclic triaryl (Z)-olefins possessing a 3,5-di-tert-butyl-4-hydroxyphenyl pharmacophore: dual inhibitors of cyclooxygenases and lipoxygenases.
    Moreau A, Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Aug 01; 14(15):5340-50. PubMed ID: 16677817
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.
    Rao PN, Chen QH, Knaus EE.
    Bioorg Med Chem Lett; 2005 Nov 01; 15(21):4842-5. PubMed ID: 16143531
    [Abstract] [Full Text] [Related]

  • 11. 3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.
    Ranatunge RR, Earl RA, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Schwalb DJ, Young DV, Zemtseva IS.
    Bioorg Med Chem Lett; 2004 Dec 20; 14(24):6049-52. PubMed ID: 15546727
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.
    Yu G, Praveen Rao PN, Chowdhury MA, Abdellatif KR, Dong Y, Das D, Velázquez CA, Suresh MR, Knaus EE.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2168-73. PubMed ID: 20202839
    [Abstract] [Full Text] [Related]

  • 13. Computer-aided discovery of anti-inflammatory thiazolidinones with dual cyclooxygenase/lipoxygenase inhibition.
    Geronikaki AA, Lagunin AA, Hadjipavlou-Litina DI, Eleftheriou PT, Filimonov DA, Poroikov VV, Alam I, Saxena AK.
    J Med Chem; 2008 Mar 27; 51(6):1601-9. PubMed ID: 18311898
    [Abstract] [Full Text] [Related]

  • 14. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.
    Li Y, Chen SH, Ou TM, Tan JH, Li D, Gu LQ, Huang ZS.
    Bioorg Med Chem; 2011 Mar 15; 19(6):2074-83. PubMed ID: 21349729
    [Abstract] [Full Text] [Related]

  • 15. Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation.
    Ergün BC, Nuñez MT, Labeaga L, Ledo F, Darlington J, Bain G, Cakir B, Banoglu E.
    Arzneimittelforschung; 2010 Mar 15; 60(8):497-505. PubMed ID: 20863006
    [Abstract] [Full Text] [Related]

  • 16. Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.
    Chen CS, Tan CM, Huang CH, Chang LC, Wang JP, Cheng FC, Chern JW.
    Bioorg Med Chem; 2010 Jan 15; 18(2):597-604. PubMed ID: 20056549
    [Abstract] [Full Text] [Related]

  • 17. Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and 3D-QSAR analyses on DHDMBF analogues.
    Zheng M, Zhang Z, Zhu W, Liu H, Luo X, Chen K, Jiang H.
    Bioorg Med Chem; 2006 May 15; 14(10):3428-37. PubMed ID: 16458008
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.
    Lai Y, Ma L, Huang W, Yu X, Zhang Y, Ji H, Tian J.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7349-53. PubMed ID: 21055929
    [Abstract] [Full Text] [Related]

  • 19. Rationalization of physicochemical characters of 1,5-diarylpyrazole analogs as dual (COX-2/LOX-5) inhibitors: a QSAR approach.
    Revathi S, Gupta AK, Soni LK, Kavitha S, Wagh R, Kaskhedikar SG.
    J Pharm Biomed Anal; 2006 Sep 18; 42(2):283-9. PubMed ID: 16781106
    [Abstract] [Full Text] [Related]

  • 20. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.
    Moon C, Ahn M, Wie MB, Kim HM, Koh CS, Hong SC, Kim MD, Tanuma N, Matsumoto Y, Shin T.
    Brain Res; 2005 Feb 28; 1035(2):206-10. PubMed ID: 15722060
    [Abstract] [Full Text] [Related]

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