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201 related items for PubMed ID: 15665116

  • 1. Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells.
    Ramos AM, Fernández C, Amrán D, Sancho P, de Blas E, Aller P.
    Blood; 2005 May 15; 105(10):4013-20. PubMed ID: 15665116
    [Abstract] [Full Text] [Related]

  • 2. Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.
    Sánchez Y, Simón GP, Calviño E, de Blas E, Aller P.
    J Pharmacol Exp Ther; 2010 Oct 15; 335(1):114-23. PubMed ID: 20605902
    [Abstract] [Full Text] [Related]

  • 3. Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells.
    Tabellini G, Cappellini A, Tazzari PL, Falà F, Billi AM, Manzoli L, Cocco L, Martelli AM.
    J Cell Physiol; 2005 Feb 15; 202(2):623-34. PubMed ID: 15316930
    [Abstract] [Full Text] [Related]

  • 4. Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis.
    Ramos AM, Fernandez C, Amrán D, Esteban D, de Blas E, Palacios MA, Aller P.
    J Cell Physiol; 2006 Dec 15; 209(3):1006-15. PubMed ID: 16972261
    [Abstract] [Full Text] [Related]

  • 5. Arsenic trioxide sensitizes promonocytic leukemia cells to TNFalpha-induced apoptosis via p38-MAPK-regulated activation of both receptor-mediated and mitochondrial pathways.
    Amrán D, Sánchez Y, Fernández C, Ramos AM, de Blas E, Bréard J, Calle C, Aller P.
    Biochim Biophys Acta; 2007 Nov 15; 1773(11):1653-63. PubMed ID: 17673311
    [Abstract] [Full Text] [Related]

  • 6. Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation.
    Calviño E, Estañ MC, Simón GP, Sancho P, Boyano-Adánez Mdel C, de Blas E, Bréard J, Aller P.
    Biochem Pharmacol; 2011 Dec 01; 82(11):1619-29. PubMed ID: 21889928
    [Abstract] [Full Text] [Related]

  • 7. Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines.
    Ramos AM, Aller P.
    Biochem Pharmacol; 2008 May 15; 75(10):1912-23. PubMed ID: 18359480
    [Abstract] [Full Text] [Related]

  • 8. Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK).
    Sánchez Y, Amrán D, Fernández C, de Blas E, Aller P.
    Int J Cancer; 2008 Sep 01; 123(5):1205-14. PubMed ID: 18546268
    [Abstract] [Full Text] [Related]

  • 9. Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1.
    Wang R, Liu C, Xia L, Zhao G, Gabrilove J, Waxman S, Jing Y.
    Clin Cancer Res; 2012 Dec 15; 18(24):6690-701. PubMed ID: 23082001
    [Abstract] [Full Text] [Related]

  • 10. Arsenic trioxide-induced apoptosis in U937 cells involve generation of reactive oxygen species and inhibition of Akt.
    Choi YJ, Park JW, Suh SI, Mun KC, Bae JH, Song DK, Kim SP, Kwon TK.
    Int J Oncol; 2002 Sep 15; 21(3):603-10. PubMed ID: 12168106
    [Abstract] [Full Text] [Related]

  • 11. Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells.
    Wang R, Xia L, Gabrilove J, Waxman S, Jing Y.
    Leukemia; 2013 Feb 15; 27(2):315-24. PubMed ID: 22751450
    [Abstract] [Full Text] [Related]

  • 12. Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway.
    Wang X, Ren JH, Lin F, Wei JX, Long M, Yan L, Zhang HZ.
    Cancer Biol Ther; 2010 Sep 15; 10(6):632-43. PubMed ID: 20657188
    [Abstract] [Full Text] [Related]

  • 13. Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide.
    Iwama K, Nakajo S, Aiuchi T, Nakaya K.
    Int J Cancer; 2001 May 15; 92(4):518-26. PubMed ID: 11304686
    [Abstract] [Full Text] [Related]

  • 14. The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
    Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, Grant S.
    Cancer Res; 2003 Apr 15; 63(8):1822-33. PubMed ID: 12702569
    [Abstract] [Full Text] [Related]

  • 15. Inactivation of Akt by arsenic trioxide induces cell death via mitochondrial-mediated apoptotic signaling in SGC-7901 human gastric cancer cells.
    Gao YH, Zhang HP, Yang SM, Yang Y, Ma YY, Zhang XY, Yang YM.
    Oncol Rep; 2014 Apr 15; 31(4):1645-52. PubMed ID: 24482137
    [Abstract] [Full Text] [Related]

  • 16. Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis.
    Kitamura K, Minami Y, Yamamoto K, Akao Y, Kiyoi H, Saito H, Naoe T.
    Leukemia; 2000 Oct 15; 14(10):1743-50. PubMed ID: 11021749
    [Abstract] [Full Text] [Related]

  • 17. Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.
    Redondo-Muñoz J, Escobar-Díaz E, Hernández Del Cerro M, Pandiella A, Terol MJ, García-Marco JA, García-Pardo A.
    Clin Cancer Res; 2010 Sep 01; 16(17):4382-91. PubMed ID: 20534739
    [Abstract] [Full Text] [Related]

  • 18. Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione.
    Xiao G, Tang X, Yao C, Wang C.
    Acta Biochim Biophys Sin (Shanghai); 2011 Sep 01; 43(9):712-21. PubMed ID: 21785114
    [Abstract] [Full Text] [Related]

  • 19. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations.
    Zhu XH, Shen YL, Jing YK, Cai X, Jia PM, Huang Y, Tang W, Shi GY, Sun YP, Dai J, Wang ZY, Chen SJ, Zhang TD, Waxman S, Chen Z, Chen GQ.
    J Natl Cancer Inst; 1999 May 05; 91(9):772-8. PubMed ID: 10328107
    [Abstract] [Full Text] [Related]

  • 20. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.
    Rahmani M, Reese E, Dai Y, Bauer C, Payne SG, Dent P, Spiegel S, Grant S.
    Cancer Res; 2005 Mar 15; 65(6):2422-32. PubMed ID: 15781658
    [Abstract] [Full Text] [Related]

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