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162 related items for PubMed ID: 15667205

  • 1. Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.
    Coggins BE, McClerren AL, Jiang L, Li X, Rudolph J, Hindsgaul O, Raetz CR, Zhou P.
    Biochemistry; 2005 Feb 01; 44(4):1114-26. PubMed ID: 15667205
    [Abstract] [Full Text] [Related]

  • 2. Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.
    Jackman JE, Raetz CR, Fierke CA.
    Biochemistry; 2001 Jan 16; 40(2):514-23. PubMed ID: 11148046
    [Abstract] [Full Text] [Related]

  • 3. Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
    McClerren AL, Zhou P, Guan Z, Raetz CR, Rudolph J.
    Biochemistry; 2005 Feb 01; 44(4):1106-13. PubMed ID: 15667204
    [Abstract] [Full Text] [Related]

  • 4. Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.
    Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CR, Zhou P.
    Nat Struct Biol; 2003 Aug 01; 10(8):645-51. PubMed ID: 12833153
    [Abstract] [Full Text] [Related]

  • 5. Design and synthesis of potent Gram-negative specific LpxC inhibitors.
    Mansoor UF, Vitharana D, Reddy PA, Daubaras DL, McNicholas P, Orth P, Black T, Siddiqui MA.
    Bioorg Med Chem Lett; 2011 Feb 15; 21(4):1155-61. PubMed ID: 21273067
    [Abstract] [Full Text] [Related]

  • 6. Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.
    Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW.
    Proc Natl Acad Sci U S A; 2003 Jul 08; 100(14):8146-50. PubMed ID: 12819349
    [Abstract] [Full Text] [Related]

  • 7. Crystal structure of A. aeolicus LpxC with bound product suggests alternate deacetylation mechanism.
    Miller MD, Gao N, Ross PL, Olivier NB.
    Proteins; 2015 Sep 08; 83(9):1706-19. PubMed ID: 26177919
    [Abstract] [Full Text] [Related]

  • 8. Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis.
    Hernick M, Fierke CA.
    Biochemistry; 2006 Dec 26; 45(51):15240-8. PubMed ID: 17176046
    [Abstract] [Full Text] [Related]

  • 9. Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.
    Gennadios HA, Whittington DA, Li X, Fierke CA, Christianson DW.
    Biochemistry; 2006 Jul 04; 45(26):7940-8. PubMed ID: 16800620
    [Abstract] [Full Text] [Related]

  • 10. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs.
    Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O, Raetz CR.
    J Biol Chem; 2000 Apr 14; 275(15):11002-9. PubMed ID: 10753902
    [Abstract] [Full Text] [Related]

  • 11. Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.
    Mdluli KE, Witte PR, Kline T, Barb AW, Erwin AL, Mansfield BE, McClerren AL, Pirrung MC, Tumey LN, Warrener P, Raetz CR, Stover CK.
    Antimicrob Agents Chemother; 2006 Jun 14; 50(6):2178-84. PubMed ID: 16723580
    [Abstract] [Full Text] [Related]

  • 12. UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.
    Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA.
    J Biol Chem; 2005 Apr 29; 280(17):16969-78. PubMed ID: 15705580
    [Abstract] [Full Text] [Related]

  • 13. Exploring the UDP pocket of LpxC through amino acid analogs.
    Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W.
    Bioorg Med Chem Lett; 2013 Apr 15; 23(8):2362-7. PubMed ID: 23499237
    [Abstract] [Full Text] [Related]

  • 14. Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design.
    Kalinin DV, Holl R.
    Curr Top Med Chem; 2016 Apr 15; 16(21):2379-430. PubMed ID: 27072691
    [Abstract] [Full Text] [Related]

  • 15. Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC.
    Shin H, Gennadios HA, Whittington DA, Christianson DW.
    Bioorg Med Chem; 2007 Apr 01; 15(7):2617-23. PubMed ID: 17296300
    [Abstract] [Full Text] [Related]

  • 16. Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514.
    Coggins BE, Li X, Hindsgaul O, Raetz CR, Zhou P.
    J Biomol NMR; 2004 Feb 01; 28(2):201-2. PubMed ID: 14755169
    [No Abstract] [Full Text] [Related]

  • 17. Binding of uridine 5'-diphosphate in the "basic patch" of the zinc deacetylase LpxC and implications for substrate binding.
    Gennadios HA, Christianson DW.
    Biochemistry; 2006 Dec 26; 45(51):15216-23. PubMed ID: 17176043
    [Abstract] [Full Text] [Related]

  • 18. Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
    Warmus JS, Quinn CL, Taylor C, Murphy ST, Johnson TA, Limberakis C, Ortwine D, Bronstein J, Pagano P, Knafels JD, Lightle S, Mochalkin I, Brideau R, Podoll T.
    Bioorg Med Chem Lett; 2012 Apr 01; 22(7):2536-43. PubMed ID: 22401863
    [Abstract] [Full Text] [Related]

  • 19. Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria.
    Zhou P, Hong J.
    Acc Chem Res; 2021 Apr 06; 54(7):1623-1634. PubMed ID: 33720682
    [Abstract] [Full Text] [Related]

  • 20. Recent Process in the Inhibitors of UDP-3-O-(R-3-hydroxyacyl)-Nacetylglucosamine Deacetylase (LpxC) Against Gram-Negative Bacteria.
    Liu F, Ma S.
    Mini Rev Med Chem; 2018 Apr 06; 18(4):310-323. PubMed ID: 27739357
    [Abstract] [Full Text] [Related]

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