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1223 related items for PubMed ID: 15669079

  • 1. Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene.
    Menendez JA, Vellon L, Oza BP, Lupu R.
    J Cell Biochem; 2005 Apr 01; 94(5):857-63. PubMed ID: 15669079
    [Abstract] [Full Text] [Related]

  • 2. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
    Menendez JA, Mehmi I, Atlas E, Colomer R, Lupu R.
    Int J Oncol; 2004 Mar 01; 24(3):591-608. PubMed ID: 14767544
    [Abstract] [Full Text] [Related]

  • 3. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.
    Menendez JA, Ropero S, Mehmi I, Atlas E, Colomer R, Lupu R.
    Int J Oncol; 2004 Jun 01; 24(6):1369-83. PubMed ID: 15138577
    [Abstract] [Full Text] [Related]

  • 4. RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells.
    Menendez JA, Lupu R.
    Int J Mol Med; 2005 Jan 01; 15(1):33-40. PubMed ID: 15583825
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  • 5. DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes.
    Menendez JA, Vellon L, Lupu R.
    Int J Mol Med; 2006 Dec 01; 18(6):1081-7. PubMed ID: 17089011
    [Abstract] [Full Text] [Related]

  • 6. Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.
    Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Simioni C, Leung E, Maclennan S, Baraldi PG, Borea PA.
    Mol Pharmacol; 2007 Aug 01; 72(2):395-406. PubMed ID: 17488804
    [Abstract] [Full Text] [Related]

  • 7. [Effect of silencing HIF-1alpha by RNA interference on expression of vascular endothelial growth factor in osteosarcoma cell line SaOS-2 under hypoxia].
    Wu Q, Yang SH, Wang RY, Ye SN, Xia T, Ma DZ.
    Ai Zheng; 2005 May 01; 24(5):531-5. PubMed ID: 15890092
    [Abstract] [Full Text] [Related]

  • 8. Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
    Menendez JA, Mehmi I, Verma VA, Teng PK, Lupu R.
    Mol Carcinog; 2004 Nov 01; 41(3):164-78. PubMed ID: 15390078
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  • 10. A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma.
    Das B, Yeger H, Tsuchida R, Torkin R, Gee MF, Thorner PS, Shibuya M, Malkin D, Baruchel S.
    Cancer Res; 2005 Aug 15; 65(16):7267-75. PubMed ID: 16103078
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  • 12. Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells.
    Menendez JA, Vellon L, Lupu R.
    Med Hypotheses; 2005 Aug 15; 64(5):997-1001. PubMed ID: 15780499
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis.
    Menendez JA, Colomer R, Lupu R.
    Med Hypotheses; 2005 Aug 15; 64(2):337-41. PubMed ID: 15607568
    [Abstract] [Full Text] [Related]

  • 14. Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells.
    Menendez JA, Lupu R.
    Arch Immunol Ther Exp (Warsz); 2004 Aug 15; 52(6):414-26. PubMed ID: 15577743
    [Abstract] [Full Text] [Related]

  • 15. Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A.
    Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D'Amore PA, Yoon SS.
    Cancer Res; 2005 Jul 01; 65(13):5881-9. PubMed ID: 15994966
    [Abstract] [Full Text] [Related]

  • 16. Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.
    Bobarykina AY, Minchenko DO, Opentanova IL, Moenner M, Caro J, Esumi H, Minchenko OH.
    Acta Biochim Pol; 2006 Jul 01; 53(4):789-99. PubMed ID: 17143338
    [Abstract] [Full Text] [Related]

  • 17. Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells.
    Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Leung E, Maclennan S, Borea PA.
    Biochem Pharmacol; 2006 Jun 28; 72(1):19-31. PubMed ID: 16682012
    [Abstract] [Full Text] [Related]

  • 18. The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
    Menendez JA, Oza BP, Colomer R, Lupu R.
    Int J Oncol; 2005 Jun 28; 26(6):1507-15. PubMed ID: 15870863
    [Abstract] [Full Text] [Related]

  • 19. Inhibitor of DNA binding 1 activates vascular endothelial growth factor through enhancing the stability and activity of hypoxia-inducible factor-1alpha.
    Kim HJ, Chung H, Yoo YG, Kim H, Lee JY, Lee MO, Kong G.
    Mol Cancer Res; 2007 Apr 28; 5(4):321-9. PubMed ID: 17426247
    [Abstract] [Full Text] [Related]

  • 20. Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.
    Catrina SB, Botusan IR, Rantanen A, Catrina AI, Pyakurel P, Savu O, Axelson M, Biberfeld P, Poellinger L, Brismar K.
    Clin Cancer Res; 2006 Aug 01; 12(15):4506-14. PubMed ID: 16899596
    [Abstract] [Full Text] [Related]

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