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111 related items for PubMed ID: 15683365

  • 1. Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates.
    Shokeer A, Larsson AK, Mannervik B.
    Biochem J; 2005 May 15; 388(Pt 1):387-92. PubMed ID: 15683365
    [Abstract] [Full Text] [Related]

  • 2. Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1.
    Shokeer A, Mannervik B.
    Biochim Biophys Acta; 2010 Apr 15; 1800(4):466-73. PubMed ID: 20097269
    [Abstract] [Full Text] [Related]

  • 3. Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant.
    Tars K, Larsson AK, Shokeer A, Olin B, Mannervik B, Kleywegt GJ.
    J Mol Biol; 2006 Jan 06; 355(1):96-105. PubMed ID: 16298388
    [Abstract] [Full Text] [Related]

  • 4. Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface.
    Josephy PD, Pan D, Ianni MD, Mannervik B.
    Arch Biochem Biophys; 2011 Sep 15; 513(2):87-93. PubMed ID: 21781954
    [Abstract] [Full Text] [Related]

  • 5. Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation.
    Nilsson LO, Gustafsson A, Mannervik B.
    Proc Natl Acad Sci U S A; 2000 Aug 15; 97(17):9408-12. PubMed ID: 10900265
    [Abstract] [Full Text] [Related]

  • 6. Glutathione transferase theta 1-1-dependent metabolism of the water disinfection byproduct bromodichloromethane.
    Ross MK, Pegram RA.
    Chem Res Toxicol; 2003 Feb 15; 16(2):216-26. PubMed ID: 12588193
    [Abstract] [Full Text] [Related]

  • 7. Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme.
    Jemth P, Mannervik B.
    Arch Biochem Biophys; 1997 Dec 15; 348(2):247-54. PubMed ID: 9434735
    [Abstract] [Full Text] [Related]

  • 8. Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases.
    Ivarsson Y, Mannervik B.
    Protein Eng Des Sel; 2005 Dec 15; 18(12):607-16. PubMed ID: 16251220
    [Abstract] [Full Text] [Related]

  • 9. Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli.
    Jiang Z, Arnér ES, Mu Y, Johansson L, Shi J, Zhao S, Liu S, Wang R, Zhang T, Yan G, Liu J, Shen J, Luo G.
    Biochem Biophys Res Commun; 2004 Aug 13; 321(1):94-101. PubMed ID: 15358220
    [Abstract] [Full Text] [Related]

  • 10. Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents.
    Larsson AK, Shokeer A, Mannervik B.
    Arch Biochem Biophys; 2010 May 13; 497(1-2):28-34. PubMed ID: 20211594
    [Abstract] [Full Text] [Related]

  • 11. Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse. Comparison of the tissue distribution of GST T1-1 with that of classes Alpha, Mu and Pi GST in human.
    Sherratt PJ, Pulford DJ, Harrison DJ, Green T, Hayes JD.
    Biochem J; 1997 Sep 15; 326 ( Pt 3)(Pt 3):837-46. PubMed ID: 9307035
    [Abstract] [Full Text] [Related]

  • 12. Molecular cloning and characterization of a glutathione S-transferase from largemouth bass (Micropterus salmoides) liver that is involved in the detoxification of 4-hydroxynonenal.
    Doi AM, Pham RT, Hughes EM, Barber DS, Gallagher EP.
    Biochem Pharmacol; 2004 Jun 01; 67(11):2129-39. PubMed ID: 15135309
    [Abstract] [Full Text] [Related]

  • 13. Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1.
    Widersten M, Björnestedt R, Mannervik B.
    Biochemistry; 1996 Jun 18; 35(24):7731-42. PubMed ID: 8672473
    [Abstract] [Full Text] [Related]

  • 14. The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa.
    Dirven HA, Dictus EL, Broeders NL, van Ommen B, van Bladeren PJ.
    Cancer Res; 1995 Apr 15; 55(8):1701-6. PubMed ID: 7712478
    [Abstract] [Full Text] [Related]

  • 15. Engineering GST M2-2 for high activity with indene 1,2-oxide and indication of an H-site residue sustaining catalytic promiscuity.
    Norrgård MA, Mannervik B.
    J Mol Biol; 2011 Sep 09; 412(1):111-20. PubMed ID: 21821040
    [Abstract] [Full Text] [Related]

  • 16. A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes.
    Comstock KE, Widersten M, Hao XY, Henner WD, Mannervik B.
    Arch Biochem Biophys; 1994 Jun 09; 311(2):487-95. PubMed ID: 8203914
    [Abstract] [Full Text] [Related]

  • 17. Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity.
    Sherratt PJ, Williams S, Foster J, Kernohan N, Green T, Hayes JD.
    Toxicol Appl Pharmacol; 2002 Mar 01; 179(2):89-97. PubMed ID: 11884241
    [Abstract] [Full Text] [Related]

  • 18. Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine.
    Modén O, Zhang W, Mannervik B.
    Protein Eng Des Sel; 2012 Apr 01; 25(4):189-97. PubMed ID: 22334756
    [Abstract] [Full Text] [Related]

  • 19. Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity.
    Ginsberg G, Smolenski S, Hattis D, Guyton KZ, Johns DO, Sonawane B.
    J Toxicol Environ Health B Crit Rev; 2009 Apr 01; 12(5-6):389-439. PubMed ID: 20183528
    [Abstract] [Full Text] [Related]

  • 20. Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library.
    Kurtovic S, Runarsdottir A, Emrén LO, Larsson AK, Mannervik B.
    Protein Eng Des Sel; 2007 May 01; 20(5):243-56. PubMed ID: 17468114
    [Abstract] [Full Text] [Related]

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