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126 related items for PubMed ID: 15686941

  • 1. Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
    Bonnefous C, Vernier JM, Hutchinson JH, Chung J, Reyes-Manalo G, Kamenecka T.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1197-200. PubMed ID: 15686941
    [Abstract] [Full Text] [Related]

  • 2. Dipyridyl amines: potent metabotropic glutamate subtype 5 receptor antagonists.
    Kamenecka TM, Bonnefous C, Govek S, Vernier JM, Hutchinson J, Chung J, Reyes-Manalo G, Anderson JJ.
    Bioorg Med Chem Lett; 2005 Oct 01; 15(19):4350-3. PubMed ID: 16039855
    [Abstract] [Full Text] [Related]

  • 3. Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
    Chua PC, Nagasawa JY, Bleicher LS, Munoz B, Schweiger EJ, Tehrani L, Anderson JJ, Cramer M, Chung J, Green MD, King CD, Reyes-Manalo G, Cosford ND.
    Bioorg Med Chem Lett; 2005 Oct 15; 15(20):4589-93. PubMed ID: 16115767
    [Abstract] [Full Text] [Related]

  • 4. 3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
    Poon SF, Eastman BW, Chapman DF, Chung J, Cramer M, Holtz G, Cosford ND, Smith ND.
    Bioorg Med Chem Lett; 2004 Nov 15; 14(22):5477-80. PubMed ID: 15482907
    [Abstract] [Full Text] [Related]

  • 5. Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.
    Spanka C, Glatthar R, Desrayaud S, Fendt M, Orain D, Troxler T, Vranesic I.
    Bioorg Med Chem Lett; 2010 Jan 01; 20(1):184-8. PubMed ID: 19931453
    [Abstract] [Full Text] [Related]

  • 6. IRAK-4 inhibitors. Part 1: a series of amides.
    Buckley GM, Gowers L, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V, Fraser JL.
    Bioorg Med Chem Lett; 2008 Jun 01; 18(11):3211-4. PubMed ID: 18474425
    [Abstract] [Full Text] [Related]

  • 7. Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.
    Smith ND, Poon SF, Huang D, Green M, King C, Tehrani L, Roppe JR, Chung J, Chapman DP, Cramer M, Cosford ND.
    Bioorg Med Chem Lett; 2004 Nov 15; 14(22):5481-4. PubMed ID: 15482908
    [Abstract] [Full Text] [Related]

  • 8. 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
    Roppe JR, Wang B, Huang D, Tehrani L, Kamenecka T, Schweiger EJ, Anderson JJ, Brodkin J, Jiang X, Cramer M, Chung J, Reyes-Manalo G, Munoz B, Cosford ND.
    Bioorg Med Chem Lett; 2004 Aug 02; 14(15):3993-6. PubMed ID: 15225713
    [Abstract] [Full Text] [Related]

  • 9. 3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.
    Tehrani LR, Smith ND, Huang D, Poon SF, Roppe JR, Seiders TJ, Chapman DF, Chung J, Cramer M, Cosford ND.
    Bioorg Med Chem Lett; 2005 Nov 15; 15(22):5061-4. PubMed ID: 16183275
    [Abstract] [Full Text] [Related]

  • 10. 2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
    Huang D, Poon SF, Chapman DF, Chung J, Cramer M, Reger TS, Roppe JR, Tehrani L, Cosford ND, Smith ND.
    Bioorg Med Chem Lett; 2004 Nov 15; 14(22):5473-6. PubMed ID: 15482906
    [Abstract] [Full Text] [Related]

  • 11. Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist.
    Ito S, Satoh A, Nagatomi Y, Hirata Y, Suzuki G, Kimura T, Satow A, Maehara S, Hikichi H, Hata M, Kawamoto H, Ohta H.
    Bioorg Med Chem; 2008 Nov 15; 16(22):9817-29. PubMed ID: 18849168
    [Abstract] [Full Text] [Related]

  • 12. Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators.
    Chae E, Shin YJ, Ryu EJ, Ji MK, Ryune Cho N, Lee KH, Jeong HJ, Kim SJ, Choi Y, Seok Oh K, Park CE, Soo Yoon Y.
    Bioorg Med Chem Lett; 2013 Apr 01; 23(7):2134-9. PubMed ID: 23434029
    [Abstract] [Full Text] [Related]

  • 13. A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).
    Bach P, Nilsson K, Wållberg A, Bauer U, Hammerland LG, Peterson A, Svensson T, Osterlund K, Karis D, Boije M, Wensbo D.
    Bioorg Med Chem Lett; 2006 Sep 15; 16(18):4792-5. PubMed ID: 16839764
    [Abstract] [Full Text] [Related]

  • 14. Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.
    Roppe J, Smith ND, Huang D, Tehrani L, Wang B, Anderson J, Brodkin J, Chung J, Jiang X, King C, Munoz B, Varney MA, Prasit P, Cosford ND.
    J Med Chem; 2004 Sep 09; 47(19):4645-8. PubMed ID: 15341479
    [Abstract] [Full Text] [Related]

  • 15. Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure.
    Ceccarelli SM, Jaeschke G, Buettelmann B, Huwyler J, Kolczewski S, Peters JU, Prinssen E, Porter R, Spooren W, Vieira E.
    Bioorg Med Chem Lett; 2007 Mar 01; 17(5):1302-6. PubMed ID: 17189691
    [Abstract] [Full Text] [Related]

  • 16. Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.
    Kulkarni SS, Nightingale B, Dersch CM, Rothman RB, Newman AH.
    Bioorg Med Chem Lett; 2006 Jul 01; 16(13):3371-5. PubMed ID: 16678408
    [Abstract] [Full Text] [Related]

  • 17. Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues.
    Wållberg A, Nilsson K, Osterlund K, Peterson A, Elg S, Raboisson P, Bauer U, Hammerland LG, Mattsson JP.
    Bioorg Med Chem Lett; 2006 Mar 01; 16(5):1142-5. PubMed ID: 16380255
    [Abstract] [Full Text] [Related]

  • 18. Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
    Zhao H, Serby MD, Xin Z, Szczepankiewicz BG, Liu M, Kosogof C, Liu B, Nelson LT, Johnson EF, Wang S, Pederson T, Gum RJ, Clampit JE, Haasch DL, Abad-Zapatero C, Fry EH, Rondinone C, Trevillyan JM, Sham HL, Liu G.
    J Med Chem; 2006 Jul 27; 49(15):4455-8. PubMed ID: 16854050
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity.
    Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD.
    Bioorg Med Chem; 2005 Jan 03; 13(1):197-209. PubMed ID: 15582465
    [Abstract] [Full Text] [Related]

  • 20. Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
    Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J, Tawa P, Nicholson DW, Zamboni RJ.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1173-80. PubMed ID: 15686936
    [Abstract] [Full Text] [Related]

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