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122 related items for PubMed ID: 15701018

  • 1. Phosphodiester cleavage of guanylyl-(3',3')-(2'-amino-2'-deoxyuridine): rate acceleration by the 2'-amino function.
    Ora M, Linjalahti H, Lönnberg H.
    J Am Chem Soc; 2005 Feb 16; 127(6):1826-32. PubMed ID: 15701018
    [Abstract] [Full Text] [Related]

  • 2. Hydrolytic reactions of guanosyl-(3',3')-uridine and guanosyl-(3',3')-(2',5'-di-O-methyluridine).
    Kiviniemi A, Lönnberg T, Ora M.
    J Am Chem Soc; 2004 Sep 08; 126(35):11040-5. PubMed ID: 15339190
    [Abstract] [Full Text] [Related]

  • 3. Hydrolytic stability of 2',3'-O-methyleneadenos-5'-yl 2',5'-di-O-methylurid-3'-yl 5'-O-methylurid-3'(2')-yl phosphate: implications to feasibility of existence of phosphate-branched RNA under physiological conditions.
    Lönnberg T, Kiiski J, Mikkola S.
    Org Biomol Chem; 2005 Mar 21; 3(6):1089-96. PubMed ID: 15750653
    [Abstract] [Full Text] [Related]

  • 4. Hydrolytic reactions of diribonucleoside 3',5'-(3'-N-phosphoramidates): kinetics and mechanisms for the P-O and P-N bond cleavage of 3'-amino-3'-deoxyuridylyl-3',5'-uridine.
    Ora M, Mattila K, Lönnberg T, Oivanen M, Lönnberg H.
    J Am Chem Soc; 2002 Dec 04; 124(48):14364-72. PubMed ID: 12452710
    [Abstract] [Full Text] [Related]

  • 5. Hydrolysis of 2',3'-O-methyleneadenosin-5'-yl bis-5'-O-methyluridin-3'-yl phosphate: the 2'-hydroxy group stabilizes the phosphorane intermediate, not the departing 3'-oxyanion, by hydrogen bonding.
    Lönnberg T, Korhonen J.
    J Am Chem Soc; 2005 Jun 01; 127(21):7752-8. PubMed ID: 15913365
    [Abstract] [Full Text] [Related]

  • 6. Thio effects on the departure of the 3'-linked ribonucleoside from diribonucleoside 3',3'-phosphorodithioate diesters and triribonucleoside 3',3',5'-phosphoromonothioate triesters: implications for ribozyme catalysis.
    Lönnberg T, Ora M, Virtanen S, Lönnberg H.
    Chemistry; 2007 Jun 01; 13(16):4614-27. PubMed ID: 17330317
    [Abstract] [Full Text] [Related]

  • 7. Phosphorane intermediate vs. leaving group stabilization by intramolecular hydrogen bonding in the cleavage of trinucleoside monophosphates: implications for understanding catalysis by the large ribozymes.
    Lönnberg T, Laine M.
    Org Biomol Chem; 2010 Jan 21; 8(2):349-56. PubMed ID: 20066269
    [Abstract] [Full Text] [Related]

  • 8. Hydrolysis of 2',3'-O-methyleneadenos-5'-yl bis(2',5'-di-O-methylurid-3'-yl) phosphate, a sugar O-alkylated trinucleoside 3',3',5'-monophosphate: implications for the mechanism of large ribozymes.
    Lönnberg T, Mikkola S.
    J Org Chem; 2004 Feb 06; 69(3):802-10. PubMed ID: 14750807
    [Abstract] [Full Text] [Related]

  • 9. Substrate specificity of an active dinuclear Zn(II) catalyst for cleavage of RNA analogues and a dinucleoside.
    O'Donoghue A, Pyun SY, Yang MY, Morrow JR, Richard JP.
    J Am Chem Soc; 2006 Feb 08; 128(5):1615-21. PubMed ID: 16448134
    [Abstract] [Full Text] [Related]

  • 10. Hydrolytic reactions of the phosphorodithioate analogue of uridylyl(3',5')uridine: kinetics and mechanisms for the cleavage, desulfurization, and isomerization of the internucleosidic linkage.
    Ora M, Jarvi J, Oivanen M, Lonnberg H.
    J Org Chem; 2000 May 09; 65(9):2651-7. PubMed ID: 10808437
    [Abstract] [Full Text] [Related]

  • 11. The dinuclear Zn(II) complex catalyzed cyclization of a series of 2-hydroxypropyl aryl phosphate RNA models: progressive change in mechanism from rate-limiting P-O bond cleavage to substrate binding.
    Bunn SE, Liu CT, Lu ZL, Neverov AA, Brown RS.
    J Am Chem Soc; 2007 Dec 26; 129(51):16238-48. PubMed ID: 18047345
    [Abstract] [Full Text] [Related]

  • 12. Cleavage of the phosphodiester bond of uridylyl-(3',5')-8-carboxymethylaminoadenosine by hydronium, hydroxide and zinc(II) ions: a model study aimed at elucidating the potential of a carboxylate function as an intramolecular catalyst.
    Mikkola S, Oivanen M, Neuvonen K, Piitari S, Ketomäki K, Lönnberg H.
    Nucleosides Nucleotides Nucleic Acids; 2000 Dec 26; 19(10-12):1675-92. PubMed ID: 11200265
    [Abstract] [Full Text] [Related]

  • 13. Hydrolytic reactions of thymidine 5'-o-phenyl-N-alkylphosphoramidates, models of nucleoside 5'-monophosphate prodrugs.
    Ora M, Ojanperä J, Lönnberg H.
    Chemistry; 2007 Dec 26; 13(30):8591-9. PubMed ID: 17654626
    [Abstract] [Full Text] [Related]

  • 14. Intramolecular participation of amino groups in the cleavage and isomerization of ribonucleoside 3'-phosphodiesters: the role in stabilization of the phosphorane intermediate.
    Lain L, Lönnberg H, Lönnberg T.
    Chemistry; 2013 Sep 09; 19(37):12424-34. PubMed ID: 23897743
    [Abstract] [Full Text] [Related]

  • 15. Hydrolytic reactions of diadenosine 5',5'-triphosphate.
    Mikkola S.
    Org Biomol Chem; 2004 Mar 07; 2(5):770-6. PubMed ID: 14985817
    [Abstract] [Full Text] [Related]

  • 16. Zn2+ complexes of di- and tri-nucleating azacrown ligands as base-moiety-selective cleaving agents of RNA 3',5'-phosphodiester bonds: binding to guanine base.
    Wang Q, Leino E, Jancsó A, Szilágyi I, Gajda T, Hietamäki E, Lönnberg H.
    Chembiochem; 2008 Jul 21; 9(11):1739-48. PubMed ID: 18574824
    [Abstract] [Full Text] [Related]

  • 17. An asymmetric dizinc phosphodiesterase model with phenolate and carboxylate bridges.
    Chen J, Wang X, Zhu Y, Lin J, Yang X, Li Y, Lu Y, Guo Z.
    Inorg Chem; 2005 May 16; 44(10):3422-30. PubMed ID: 15877422
    [Abstract] [Full Text] [Related]

  • 18. An exploration of mechanisms for the transformation of 8-oxoguanine to guanidinohydantoin and spiroiminodihydantoin by density functional theory.
    Munk BH, Burrows CJ, Schlegel HB.
    J Am Chem Soc; 2008 Apr 16; 130(15):5245-56. PubMed ID: 18355018
    [Abstract] [Full Text] [Related]

  • 19. Investigating the effect of hydrogen bonding environments in amide cleavage reactions at zinc(II) complexes with intramolecular amide oxygen co-ordination.
    Mareque Rivas JC, Salvagni E, Parsons S.
    Dalton Trans; 2004 Dec 21; (24):4185-92. PubMed ID: 15573171
    [Abstract] [Full Text] [Related]

  • 20. A minimalist approach to understanding the efficiency of mononuclear Zn(II) complexes as catalysts of cleavage of an RNA analog.
    Mathews RA, Rossiter CS, Morrow JR, Richard JP.
    Dalton Trans; 2007 Sep 14; (34):3804-11. PubMed ID: 17712447
    [Abstract] [Full Text] [Related]

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