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435 related items for PubMed ID: 15703831

  • 1. Significant anti-proliferation of human endometrial cancer cells by combined treatment with a selective COX-2 inhibitor NS398 and specific MEK inhibitor U0126.
    Gao J, Niwa K, Takemura M, Sun W, Onogi K, Wu Y, Seishima M, Mori H, Tamaya T.
    Int J Oncol; 2005 Mar; 26(3):737-44. PubMed ID: 15703831
    [Abstract] [Full Text] [Related]

  • 2. Differential sensitivity of chemoresistant neuroblastoma subtypes to MAPK-targeted treatment correlates with ERK, p53 expression, and signaling response to U0126.
    Eppstein AC, Sandoval JA, Klein PJ, Woodruff HA, Grosfeld JL, Hickey RJ, Malkas LH, Schmidt CM.
    J Pediatr Surg; 2006 Jan; 41(1):252-9. PubMed ID: 16410143
    [Abstract] [Full Text] [Related]

  • 3. The effect of doxorubicin on MEK-ERK signaling predicts its efficacy in HCC.
    Choi J, Yip-Schneider M, Albertin F, Wiesenauer C, Wang Y, Schmidt CM.
    J Surg Res; 2008 Dec; 150(2):219-26. PubMed ID: 18468633
    [Abstract] [Full Text] [Related]

  • 4. Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.
    Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM.
    J Pharmacol Exp Ther; 2009 Jun; 329(3):1063-70. PubMed ID: 19258520
    [Abstract] [Full Text] [Related]

  • 5. Novel combination of cyclooxygenase-2 and MEK inhibitors in human hepatocellular carcinoma provides a synergistic increase in apoptosis.
    Schmidt CM, Wang Y, Wiesenauer C.
    J Gastrointest Surg; 2003 Dec; 7(8):1024-33. PubMed ID: 14675712
    [Abstract] [Full Text] [Related]

  • 6. XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer.
    Yu LF, Wang J, Zou B, Lin MC, Wu YL, Xia HH, Sun YW, Gu Q, He H, Lam SK, Kung HF, Wong BC.
    Cancer; 2007 May 15; 109(10):1996-2003. PubMed ID: 17385215
    [Abstract] [Full Text] [Related]

  • 7. Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1.
    Du Y, Zhang S, Wang Z, Zhou W, Luan M, Yang X, Chen N.
    Oncol Rep; 2008 Sep 15; 20(3):605-11. PubMed ID: 18695912
    [Abstract] [Full Text] [Related]

  • 8. [NS398 induced apoptosis in pancreatic carcinoma cell strain BxPC-3 through a COX-2-in dependent pathway].
    Huang DS, Xu X, Zheng SS, Cheng JF.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2005 Oct 15; 27(5):601-5. PubMed ID: 16274041
    [Abstract] [Full Text] [Related]

  • 9. p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells.
    Ciccarelli C, Marampon F, Scoglio A, Mauro A, Giacinti C, De Cesaris P, Zani BM.
    Mol Cancer; 2005 Dec 13; 4():41. PubMed ID: 16351709
    [Abstract] [Full Text] [Related]

  • 10. Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1.
    Gysin S, Lee SH, Dean NM, McMahon M.
    Cancer Res; 2005 Jun 01; 65(11):4870-80. PubMed ID: 15930308
    [Abstract] [Full Text] [Related]

  • 11. Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors.
    Marampon F, Ciccarelli C, Zani BM.
    Mol Cancer; 2006 Aug 09; 5():31. PubMed ID: 16899113
    [Abstract] [Full Text] [Related]

  • 12. Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest.
    Ralstin MC, Gage EA, Yip-Schneider MT, Klein PJ, Wiebke EA, Schmidt CM.
    Mol Cancer Res; 2006 Jun 09; 4(6):387-99. PubMed ID: 16778086
    [Abstract] [Full Text] [Related]

  • 13. A selective cyclooxygenase-2 inhibitor, NS398, inhibits cell growth and induces cell cycle arrest in the G2/M phase in human esophageal squamous cell carcinoma cells.
    Kase S, Osaki M, Honjo S, Takeda A, Adachi K, Araki K, Ito H.
    J Exp Clin Cancer Res; 2004 Jun 09; 23(2):301-7. PubMed ID: 15354416
    [Abstract] [Full Text] [Related]

  • 14. Cyclooxygenase-2 inhibitor NS398 enhances antitumor effect of irradiation on hormone refractory human prostate carcinoma cells.
    Wen B, Deutsch E, Eschwege P, De Crevoisier R, Nasr E, Eschwege F, Bourhis J.
    J Urol; 2003 Nov 09; 170(5):2036-9. PubMed ID: 14532848
    [Abstract] [Full Text] [Related]

  • 15. [Molecular mechanism of cyclooxygenase-2 inhibitor in inhibition of proliferation of colon cancer cells by modulating Stat5 signal transduction pathway].
    Ma XT, Yu LW, Wang S, Zhang H, Du RY, Cui ZR.
    Zhonghua Yi Xue Za Zhi; 2005 Sep 21; 85(36):2566-9. PubMed ID: 16321305
    [Abstract] [Full Text] [Related]

  • 16. Rho/ROCK and MAPK signaling pathways are involved in glioblastoma cell migration and proliferation.
    Zohrabian VM, Forzani B, Chau Z, Murali R, Jhanwar-Uniyal M.
    Anticancer Res; 2009 Jan 21; 29(1):119-23. PubMed ID: 19331140
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis.
    Jiang CC, Chen LH, Gillespie S, Wang YF, Kiejda KA, Zhang XD, Hersey P.
    Cancer Res; 2007 Oct 15; 67(20):9750-61. PubMed ID: 17942905
    [Abstract] [Full Text] [Related]

  • 18. The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis.
    Minter HA, Eveson JW, Huntley S, Elder DJ, Hague A.
    Clin Cancer Res; 2003 May 15; 9(5):1885-97. PubMed ID: 12738747
    [Abstract] [Full Text] [Related]

  • 19. Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes.
    Andrieux L, Langouët S, Fautrel A, Ezan F, Krauser JA, Savouret JF, Guengerich FP, Baffet G, Guillouzo A.
    Mol Pharmacol; 2004 Apr 15; 65(4):934-43. PubMed ID: 15044623
    [Abstract] [Full Text] [Related]

  • 20. Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.
    Sutter AP, Maaser K, Gerst B, Krahn A, Zeitz M, Scherübl H.
    Biochem Pharmacol; 2004 May 01; 67(9):1701-10. PubMed ID: 15081869
    [Abstract] [Full Text] [Related]

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