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1367 related items for PubMed ID: 15721256

  • 1. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.
    Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD.
    Mol Cell; 2005 Feb 18; 17(4):525-35. PubMed ID: 15721256
    [Abstract] [Full Text] [Related]

  • 2. BH3 domains other than Bim and Bid can directly activate Bax/Bak.
    Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.
    J Biol Chem; 2011 Jan 07; 286(1):491-501. PubMed ID: 21041309
    [Abstract] [Full Text] [Related]

  • 3. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.
    Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.
    J Biol Chem; 2011 Mar 18; 286(11):9382-92. PubMed ID: 21148306
    [Abstract] [Full Text] [Related]

  • 4. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.
    Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.
    Nat Cell Biol; 2006 Dec 18; 8(12):1348-58. PubMed ID: 17115033
    [Abstract] [Full Text] [Related]

  • 5. Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.
    Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM.
    J Cell Biol; 2007 Apr 23; 177(2):277-87. PubMed ID: 17452531
    [Abstract] [Full Text] [Related]

  • 6. Direct addition of BimL to mitochondria does not lead to cytochrome c release.
    Terradillos O, Montessuit S, Huang DC, Martinou JC.
    FEBS Lett; 2002 Jul 03; 522(1-3):29-34. PubMed ID: 12095614
    [Abstract] [Full Text] [Related]

  • 7. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
    Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.
    Science; 2007 Feb 09; 315(5813):856-9. PubMed ID: 17289999
    [Abstract] [Full Text] [Related]

  • 8. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
    Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ.
    Cancer Cell; 2002 Sep 09; 2(3):183-92. PubMed ID: 12242151
    [Abstract] [Full Text] [Related]

  • 9. An interconnected hierarchical model of cell death regulation by the BCL-2 family.
    Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH.
    Nat Cell Biol; 2015 Oct 09; 17(10):1270-81. PubMed ID: 26344567
    [Abstract] [Full Text] [Related]

  • 10. Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
    Kandasamy K, Srinivasula SM, Alnemri ES, Thompson CB, Korsmeyer SJ, Bryant JL, Srivastava RK.
    Cancer Res; 2003 Apr 01; 63(7):1712-21. PubMed ID: 12670926
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of Bax-induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol.
    Polster BM, Basañez G, Young M, Suzuki M, Fiskum G.
    J Neurosci; 2003 Apr 01; 23(7):2735-43. PubMed ID: 12684459
    [Abstract] [Full Text] [Related]

  • 12. Membrane-insertion fragments of Bcl-xL, Bax, and Bid.
    García-Sáez AJ, Mingarro I, Pérez-Payá E, Salgado J.
    Biochemistry; 2004 Aug 31; 43(34):10930-43. PubMed ID: 15323553
    [Abstract] [Full Text] [Related]

  • 13. Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.
    Hockings C, Anwari K, Ninnis RL, Brouwer J, O'Hely M, Evangelista M, Hinds MG, Czabotar PE, Lee EF, Fairlie WD, Dewson G, Kluck RM.
    Cell Death Dis; 2015 Apr 23; 6(4):e1735. PubMed ID: 25906158
    [Abstract] [Full Text] [Related]

  • 14. BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes.
    Terrones O, Etxebarria A, Landajuela A, Landeta O, Antonsson B, Basañez G.
    J Biol Chem; 2008 Mar 21; 283(12):7790-803. PubMed ID: 18195012
    [Abstract] [Full Text] [Related]

  • 15. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.
    Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A.
    Cancer Cell; 2006 May 21; 9(5):351-65. PubMed ID: 16697956
    [Abstract] [Full Text] [Related]

  • 16. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
    Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC.
    Mol Cell; 2005 Feb 04; 17(3):393-403. PubMed ID: 15694340
    [Abstract] [Full Text] [Related]

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  • 18. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
    Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ.
    Mol Cell; 2001 Sep 04; 8(3):705-11. PubMed ID: 11583631
    [Abstract] [Full Text] [Related]

  • 19. B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.
    Renault TT, Elkholi R, Bharti A, Chipuk JE.
    J Biol Chem; 2014 Sep 19; 289(38):26481-26491. PubMed ID: 25096574
    [Abstract] [Full Text] [Related]

  • 20. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
    Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR.
    Science; 2004 Feb 13; 303(5660):1010-4. PubMed ID: 14963330
    [Abstract] [Full Text] [Related]

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