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Journal Abstract Search

385 related items for PubMed ID: 15726636

  • 1. Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.
    Allorge D, Bréant D, Harlow J, Chowdry J, Lo-Guidice JM, Chevalier D, Cauffiez C, Lhermitte M, Blaney FE, Tucker GT, Broly F, Ellis SW.
    Proteins; 2005 May 01; 59(2):339-46. PubMed ID: 15726636
    [Abstract] [Full Text] [Related]

  • 2. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.
    Ellis SW, Hayhurst GP, Lightfoot T, Smith G, Harlow J, Rowland-Yeo K, Larsson C, Mahling J, Lim CK, Wolf CR, Blackburn MG, Lennard MS, Tucker GT.
    Biochem J; 2000 Feb 01; 345 Pt 3(Pt 3):565-71. PubMed ID: 10642515
    [Abstract] [Full Text] [Related]

  • 3. The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6.
    Fukuda T, Nishida Y, Imaoka S, Hiroi T, Naohara M, Funae Y, Azuma J.
    Arch Biochem Biophys; 2000 Aug 15; 380(2):303-8. PubMed ID: 10933885
    [Abstract] [Full Text] [Related]

  • 4. CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability.
    Nakamura K, Ariyoshi N, Yokoi T, Ohgiya S, Chida M, Nagashima K, Inoue K, Kodama T, Shimada N, Kamataki T.
    Biochem Biophys Res Commun; 2002 May 10; 293(3):969-73. PubMed ID: 12051754
    [Abstract] [Full Text] [Related]

  • 5. Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.
    Hayhurst GP, Harlow J, Chowdry J, Gross E, Hilton E, Lennard MS, Tucker GT, Ellis SW.
    Biochem J; 2001 Apr 15; 355(Pt 2):373-9. PubMed ID: 11284724
    [Abstract] [Full Text] [Related]

  • 6. Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic isoforms.
    Yu A, Kneller BM, Rettie AE, Haining RL.
    J Pharmacol Exp Ther; 2002 Dec 15; 303(3):1291-300. PubMed ID: 12438554
    [Abstract] [Full Text] [Related]

  • 7. Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a West African population.
    Griese EU, Asante-Poku S, Ofori-Adjei D, Mikus G, Eichelbaum M.
    Pharmacogenetics; 1999 Dec 15; 9(6):715-23. PubMed ID: 10634134
    [Abstract] [Full Text] [Related]

  • 8. Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
    Flanagan JU, Maréchal JD, Ward R, Kemp CA, McLaughlin LA, Sutcliffe MJ, Roberts GC, Paine MJ, Wolf CR.
    Biochem J; 2004 Jun 01; 380(Pt 2):353-60. PubMed ID: 14992686
    [Abstract] [Full Text] [Related]

  • 9. Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6.
    Jones BC, Hyland R, Ackland M, Tyman CA, Smith DA.
    Drug Metab Dispos; 1998 Sep 01; 26(9):875-82. PubMed ID: 9733666
    [Abstract] [Full Text] [Related]

  • 10. Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.
    Keizers PH, Lussenburg BM, de Graaf C, Mentink LM, Vermeulen NP, Commandeur JN.
    Biochem Pharmacol; 2004 Dec 01; 68(11):2263-71. PubMed ID: 15498516
    [Abstract] [Full Text] [Related]

  • 11. Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).
    Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M.
    Drug Metab Dispos; 2008 Dec 01; 36(12):2460-7. PubMed ID: 18784265
    [Abstract] [Full Text] [Related]

  • 12. New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes.
    Li L, Pan RM, Porter TD, Jensen NS, Silber P, Russo G, Tine JA, Heim J, Ring B, Wedlund PJ.
    Drug Metab Dispos; 2006 Aug 01; 34(8):1411-6. PubMed ID: 16679388
    [Abstract] [Full Text] [Related]

  • 13. Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation.
    Geier M, Braun A, Fladischer P, Stepniak P, Rudroff F, Hametner C, Mihovilovic MD, Glieder A.
    FEBS J; 2013 Jul 01; 280(13):3094-108. PubMed ID: 23552177
    [Abstract] [Full Text] [Related]

  • 14. A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6.
    Klein K, Tatzel S, Raimundo S, Saussele T, Hustert E, Pleiss J, Eichelbaum M, Zanger UM.
    Drug Metab Dispos; 2007 Aug 01; 35(8):1247-50. PubMed ID: 17460029
    [Abstract] [Full Text] [Related]

  • 15. Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.
    Neafsey P, Ginsberg G, Hattis D, Sonawane B.
    J Toxicol Environ Health B Crit Rev; 2009 Aug 01; 12(5-6):334-61. PubMed ID: 20183526
    [Abstract] [Full Text] [Related]

  • 16. Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
    Marcucci KA, Pearce RE, Crespi C, Steimel DT, Leeder JS, Gaedigk A.
    Drug Metab Dispos; 2002 May 01; 30(5):595-601. PubMed ID: 11950793
    [Abstract] [Full Text] [Related]

  • 17. Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6.
    Yu A, Dong H, Lang D, Haining RL.
    Drug Metab Dispos; 2001 Nov 01; 29(11):1362-5. PubMed ID: 11602510
    [Abstract] [Full Text] [Related]

  • 18. The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase.
    Narimatsu S, Takatsu N, Yamano S, Inoue Y, Hanioka N, Kiryu K, Naito S, Gonzalez FJ, Yamamoto S.
    Chem Biol Interact; 2006 Jan 05; 159(1):47-57. PubMed ID: 16214121
    [Abstract] [Full Text] [Related]

  • 19. Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.
    Deeni YY, Paine MJ, Ayrton AD, Clarke SE, Chenery R, Wolf CR.
    Arch Biochem Biophys; 2001 Dec 01; 396(1):16-24. PubMed ID: 11716457
    [Abstract] [Full Text] [Related]

  • 20. Only truncated, not complete cytochrome p450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes.
    McConnachie LA, Phillips B, Bajpai M, Shen DD, Ho RJ.
    Drug Metab Dispos; 2003 Sep 01; 31(9):1103-7. PubMed ID: 12920165
    [Abstract] [Full Text] [Related]

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