These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

144 related items for PubMed ID: 15764717

  • 1. Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides.
    Yan Z, Li J, Huebert N, Caldwell GW, Du Y, Zhong H.
    Drug Metab Dispos; 2005 Jun; 33(6):706-13. PubMed ID: 15764717
    [Abstract] [Full Text] [Related]

  • 2. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W, Stearns RA, Wang RW, Chiu SH, Baillie TA.
    Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
    [Abstract] [Full Text] [Related]

  • 3. Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine.
    Wen B, Ma L, Rodrigues AD, Zhu M.
    Drug Metab Dispos; 2008 May; 36(5):841-50. PubMed ID: 18238857
    [Abstract] [Full Text] [Related]

  • 4. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [Abstract] [Full Text] [Related]

  • 5. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.
    Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
    [Abstract] [Full Text] [Related]

  • 6. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
    Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.
    Chem Res Toxicol; 1999 Feb; 12(2):214-22. PubMed ID: 10027801
    [Abstract] [Full Text] [Related]

  • 7. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
    Grillo MP, Ma J, Teffera Y, Waldon DJ.
    Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
    [Abstract] [Full Text] [Related]

  • 8. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
    Reddy VB, Karanam BV, Gruber WL, Wallace MA, Vincent SH, Franklin RB, Baillie TA.
    Chem Res Toxicol; 2005 May; 18(5):880-8. PubMed ID: 15892582
    [Abstract] [Full Text] [Related]

  • 9. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
    Boerma JS, Vermeulen NP, Commandeur JN.
    Chem Biol Interact; 2014 Jan 25; 207():32-40. PubMed ID: 24246759
    [Abstract] [Full Text] [Related]

  • 10. CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance.
    Prakash C, Wang W, O'Connell T, Johnson KA.
    Drug Metab Dispos; 2008 Oct 25; 36(10):2093-103. PubMed ID: 18653741
    [Abstract] [Full Text] [Related]

  • 11. Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes.
    Yu LJ, Chen Y, Deninno MP, O'Connell TN, Hop CE.
    Drug Metab Dispos; 2005 Apr 25; 33(4):484-8. PubMed ID: 15640374
    [Abstract] [Full Text] [Related]

  • 12. Development and validation of a high-throughput radiometric cyp2c9 inhibition assay using tritiated diclofenac.
    Di Marco A, Marcucci I, Chaudhary A, Taliani M, Laufer R.
    Drug Metab Dispos; 2005 Mar 25; 33(3):359-64. PubMed ID: 15608129
    [Abstract] [Full Text] [Related]

  • 13.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 14.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 15. Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.
    Madsen KG, Skonberg C, Jurva U, Cornett C, Hansen SH, Johansen TN, Olsen J.
    Chem Res Toxicol; 2008 May 25; 21(5):1107-19. PubMed ID: 18419141
    [Abstract] [Full Text] [Related]

  • 16.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 17. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W.
    Drug Metab Dispos; 2006 Jan 25; 34(1):145-51. PubMed ID: 16251255
    [Abstract] [Full Text] [Related]

  • 18. Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.
    O'Donnell JP, Dalvie DK, Kalgutkar AS, Obach RS.
    Drug Metab Dispos; 2003 Nov 25; 31(11):1369-77. PubMed ID: 14570769
    [Abstract] [Full Text] [Related]

  • 19. Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.
    Zhu M, Ma L, Zhang H, Humphreys WG.
    Anal Chem; 2007 Nov 01; 79(21):8333-41. PubMed ID: 17918967
    [Abstract] [Full Text] [Related]

  • 20. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
    Wang YP, Yan J, Fu PP, Chou MW.
    Toxicol Lett; 2005 Mar 15; 155(3):411-20. PubMed ID: 15649625
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 8.