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Journal Abstract Search

200 related items for PubMed ID: 15771426

  • 1. Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1.
    Grunewald GL, Romero FA, Criscione KR.
    J Med Chem; 2005 Mar 24; 48(6):1806-12. PubMed ID: 15771426
    [Abstract] [Full Text] [Related]

  • 2. Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
    Grunewald GL, Seim MR, Regier RC, Martin JL, Gee CL, Drinkwater N, Criscione KR.
    J Med Chem; 2006 Sep 07; 49(18):5424-33. PubMed ID: 16942016
    [Abstract] [Full Text] [Related]

  • 3. 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.
    Grunewald GL, Dahanukar VH, Teoh B, Criscione KR.
    J Med Chem; 1999 Jun 03; 42(11):1982-90. PubMed ID: 10354406
    [Abstract] [Full Text] [Related]

  • 4. Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor.
    Romero FA, Vodonick SM, Criscione KR, McLeish MJ, Grunewald GL.
    J Med Chem; 2004 Aug 26; 47(18):4483-93. PubMed ID: 15317460
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha2-adrenoceptor.
    Grunewald GL, Dahanukar VH, Jalluri RK, Criscione KR.
    J Med Chem; 1999 Jan 14; 42(1):118-34. PubMed ID: 9888838
    [Abstract] [Full Text] [Related]

  • 6. 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity.
    Grunewald GL, Romero FA, Criscione KR.
    J Med Chem; 2005 Jan 13; 48(1):134-40. PubMed ID: 15634007
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Grunewald GL, Caldwell TM, Li Q, Criscione KR.
    J Med Chem; 1999 Aug 26; 42(17):3315-23. PubMed ID: 10464018
    [Abstract] [Full Text] [Related]

  • 8. Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
    Grunewald GL, Romero FA, Seim MR, Criscione KR, Deupree JD, Spackman CC, Bylund DB.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1143-7. PubMed ID: 15686930
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Grunewald GL, Caldwell TM, Li Q, Slavica M, Criscione KR, Borchardt RT, Wang W.
    J Med Chem; 1999 Sep 09; 42(18):3588-601. PubMed ID: 10479290
    [Abstract] [Full Text] [Related]

  • 10. Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Grunewald GL, Caldwell TM, Li Q, Dahanukar VH, McNeil B, Criscione KR.
    J Med Chem; 1999 Oct 21; 42(21):4351-61. PubMed ID: 10543879
    [Abstract] [Full Text] [Related]

  • 11. Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.
    Grunewald GL, Dahanukar VH, Caldwell TM, Criscione KR.
    J Med Chem; 1997 Dec 05; 40(25):3997-4005. PubMed ID: 9406590
    [Abstract] [Full Text] [Related]

  • 12. Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors.
    Grunewald GL, Romero FA, Chieu AD, Fincham KJ, Bhat SR, Criscione KR.
    Bioorg Med Chem; 2005 Feb 15; 13(4):1261-73. PubMed ID: 15670935
    [Abstract] [Full Text] [Related]

  • 13. Assessment of the functional role of brain adrenergic neurons: chronic effects of phenylethanolamine N-methyltransferase inhibitors and alpha adrenergic receptor antagonists on brain norepinephrine metabolism.
    Stolk JM, Vantini G, Perry BD, Guchhait RB, U'Prichard DC.
    J Pharmacol Exp Ther; 1984 Sep 15; 230(3):577-86. PubMed ID: 6147403
    [Abstract] [Full Text] [Related]

  • 14. Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination.
    Grunewald GL, Seim MR, Lu J, Makboul M, Criscione KR.
    J Med Chem; 2006 May 18; 49(10):2939-52. PubMed ID: 16686536
    [Abstract] [Full Text] [Related]

  • 15. Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
    McMillan FM, Archbold J, McLeish MJ, Caine JM, Criscione KR, Grunewald GL, Martin JL.
    J Med Chem; 2004 Jan 01; 47(1):37-44. PubMed ID: 14695818
    [Abstract] [Full Text] [Related]

  • 16. 1,3-Dimethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as probes for the binding orientation of tetrahydroisoquinoline at the active site of phenylethanolamine N-methyltransferase.
    Grunewald GL, Caldwell TM, Li Q, Criscione KR.
    Bioorg Med Chem; 1999 May 01; 7(5):869-80. PubMed ID: 10400340
    [Abstract] [Full Text] [Related]

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  • 18. Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity.
    Grunewald GL, Lu J, Criscione KR, Okoro CO.
    Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5319-23. PubMed ID: 16169723
    [Abstract] [Full Text] [Related]

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  • 20. Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Grunewald GL, Caldwell TM, Li Q, Criscione KR.
    J Med Chem; 2001 Aug 16; 44(17):2849-56. PubMed ID: 11495596
    [Abstract] [Full Text] [Related]

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