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Journal Abstract Search

1123 related items for PubMed ID: 15771442

  • 1. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
    [Abstract] [Full Text] [Related]

  • 2. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
    Bhunia SS, Roy KK, Saxena AK.
    J Chem Inf Model; 2011 Aug 22; 51(8):1966-85. PubMed ID: 21761917
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  • 3. The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
    Chirgadze NY, Sall DJ, Briggs SL, Clawson DK, Zhang M, Smith GF, Schevitz RW.
    Protein Sci; 2000 Jan 22; 9(1):29-36. PubMed ID: 10739244
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  • 4. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W.
    J Mol Biol; 2001 Apr 13; 307(5):1451-86. PubMed ID: 11292354
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  • 5. Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
    Parlow JJ, Case BL, Dice TA, Fenton RL, Hayes MJ, Jones DE, Neumann WL, Wood RS, Lachance RM, Girard TJ, Nicholson NS, Clare M, Stegeman RA, Stevens AM, Stallings WC, Kurumbail RG, South MS.
    J Med Chem; 2003 Sep 11; 46(19):4050-62. PubMed ID: 12954058
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  • 9. Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2.
    Quan ML, Ellis CD, Liauw AY, Alexander RS, Knabb RM, Lam G, Wright MR, Wong PC, Wexler RR.
    J Med Chem; 1999 Jul 29; 42(15):2760-73. PubMed ID: 10425087
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  • 10. Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics.
    Marinko P, Krbavcic A, Mlinsek G, Solmajer T, Bakija AT, Stegnar M, Stojan J, Kikelj D.
    Eur J Med Chem; 2004 Mar 29; 39(3):257-65. PubMed ID: 15051174
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  • 11. Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor.
    Rupin A, Mennecier P, Lila C, de Nanteuil G, Verbeuren TJ.
    Thromb Haemost; 1997 Oct 29; 78(4):1221-7. PubMed ID: 9364988
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  • 12. Structure-based understanding of ligand affinity using human thrombin as a model system.
    Nienaber VL, Mersinger LJ, Kettner CA.
    Biochemistry; 1996 Jul 30; 35(30):9690-9. PubMed ID: 8703940
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  • 13. Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors.
    Phillips G, Davey DD, Eagen KA, Koovakkat SK, Liang A, Ng HP, Pinkerton M, Trinh L, Whitlow M, Beatty AM, Morrissey MM.
    J Med Chem; 1999 May 20; 42(10):1749-56. PubMed ID: 10346927
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  • 15. Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.
    Tucker TJ, Brady SF, Lumma WC, Lewis SD, Gardell SJ, Naylor-Olsen AM, Yan Y, Sisko JT, Stauffer KJ, Lucas BJ, Lynch JJ, Cook JJ, Stranieri MT, Holahan MA, Lyle EA, Baskin EP, Chen IW, Dancheck KB, Krueger JA, Cooper CM, Vacca JP.
    J Med Chem; 1998 Aug 13; 41(17):3210-9. PubMed ID: 9703466
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  • 17. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.
    J Mol Biol; 1996 May 24; 258(5):851-9. PubMed ID: 8637015
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