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144 related items for PubMed ID: 15778223

  • 1. Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.
    Cho J, Melnick M, Solidakis GP, Tsichlis PN.
    J Biol Chem; 2005 May 27; 280(21):20442-8. PubMed ID: 15778223
    [Abstract] [Full Text] [Related]

  • 2. Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.
    Cho J, Tsichlis PN.
    Proc Natl Acad Sci U S A; 2005 Feb 15; 102(7):2350-5. PubMed ID: 15699325
    [Abstract] [Full Text] [Related]

  • 3. Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.
    Kuriakose T, Rada B, Watford WT.
    J Biol Chem; 2014 Dec 26; 289(52):36089-100. PubMed ID: 25378393
    [Abstract] [Full Text] [Related]

  • 4. Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
    Luciano BS, Hsu S, Channavajhala PL, Lin LL, Cuozzo JW.
    J Biol Chem; 2004 Dec 10; 279(50):52117-23. PubMed ID: 15466476
    [Abstract] [Full Text] [Related]

  • 5. Cot/Tpl2 regulates IL-23 p19 expression in LPS-stimulated macrophages through ERK activation.
    Kakimoto K, Musikacharoen T, Chiba N, Bandow K, Ohnishi T, Matsuguchi T.
    J Physiol Biochem; 2010 Mar 10; 66(1):47-53. PubMed ID: 20405269
    [Abstract] [Full Text] [Related]

  • 6. Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
    Loniewski KJ, Patial S, Parameswaran N.
    Mol Immunol; 2007 Jul 10; 44(15):3715-23. PubMed ID: 17507094
    [Abstract] [Full Text] [Related]

  • 7. Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.
    López-Peláez M, Soria-Castro I, Boscá L, Fernández M, Alemany S.
    Eur J Immunol; 2011 Jun 10; 41(6):1733-41. PubMed ID: 21469113
    [Abstract] [Full Text] [Related]

  • 8. Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.
    Eliopoulos AG, Dumitru CD, Wang CC, Cho J, Tsichlis PN.
    EMBO J; 2002 Sep 16; 21(18):4831-40. PubMed ID: 12234923
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of tumor progression locus 2 protein kinase decreases lipopolysaccharide-induced tumor necrosis factor alpha production due to the inhibition of the tip-associated protein induction in RAW264.7 cells.
    Hirata K, Miyashiro M, Ogawa H, Taki H, Tobe K, Sugita T.
    Biol Pharm Bull; 2010 Sep 16; 33(7):1233-7. PubMed ID: 20606319
    [Abstract] [Full Text] [Related]

  • 10. Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.
    Robinson MJ, Beinke S, Kouroumalis A, Tsichlis PN, Ley SC.
    Mol Cell Biol; 2007 Nov 16; 27(21):7355-64. PubMed ID: 17709378
    [Abstract] [Full Text] [Related]

  • 11. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.
    Handoyo H, Stafford MJ, McManus E, Baltzis D, Peggie M, Cohen P.
    Biochem J; 2009 Oct 23; 424(1):109-18. PubMed ID: 19754427
    [Abstract] [Full Text] [Related]

  • 12. Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.
    Eliopoulos AG, Wang CC, Dumitru CD, Tsichlis PN.
    EMBO J; 2003 Aug 01; 22(15):3855-64. PubMed ID: 12881420
    [Abstract] [Full Text] [Related]

  • 13. IkappaB kinase is an essential component of the Tpl2 signaling pathway.
    Waterfield M, Jin W, Reiley W, Zhang M, Sun SC.
    Mol Cell Biol; 2004 Jul 01; 24(13):6040-8. PubMed ID: 15199157
    [Abstract] [Full Text] [Related]

  • 14. Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.
    Beinke S, Robinson MJ, Hugunin M, Ley SC.
    Mol Cell Biol; 2004 Nov 01; 24(21):9658-67. PubMed ID: 15485931
    [Abstract] [Full Text] [Related]

  • 15. Tpl2 is a key mediator of arsenite-induced signal transduction.
    Lee KM, Lee KW, Bode AM, Lee HJ, Dong Z.
    Cancer Res; 2009 Oct 15; 69(20):8043-9. PubMed ID: 19808956
    [Abstract] [Full Text] [Related]

  • 16. The tyrosine kinase Syk regulates TPL2 activation signals.
    Eliopoulos AG, Das S, Tsichlis PN.
    J Biol Chem; 2006 Jan 20; 281(3):1371-80. PubMed ID: 16291755
    [Abstract] [Full Text] [Related]

  • 17. The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.
    Berthou F, Ceppo F, Dumas K, Massa F, Vergoni B, Alemany S, Cormont M, Tanti JF.
    Mol Endocrinol; 2015 Jul 20; 29(7):1025-36. PubMed ID: 26020725
    [Abstract] [Full Text] [Related]

  • 18. Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
    Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF.
    Diabetes; 2010 Jan 20; 59(1):61-70. PubMed ID: 19808894
    [Abstract] [Full Text] [Related]

  • 19. Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.
    Zhang M, Jin W, Zhou X, Yu J, Lee AJ, Sun SC.
    Cell Signal; 2009 Apr 20; 21(4):559-66. PubMed ID: 19159680
    [Abstract] [Full Text] [Related]

  • 20. Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.
    Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT.
    J Immunol; 2009 Dec 15; 183(12):7984-93. PubMed ID: 19933865
    [Abstract] [Full Text] [Related]

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