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218 related items for PubMed ID: 1578484

  • 1. Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.
    Rosowsky A, Forsch RA, Reich VE, Freisheim JH, Moran RG.
    J Med Chem; 1992 May 01; 35(9):1578-88. PubMed ID: 1578484
    [Abstract] [Full Text] [Related]

  • 2. 5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: synthesis and binding interaction with folylpolyglutamate synthetase.
    Rosowsky A, Forsch RA, Null A, Moran RG.
    J Med Chem; 1999 Sep 09; 42(18):3510-9. PubMed ID: 10479284
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
    Rosowsky A, Forsch RA, Bader H, Freisheim JH.
    J Med Chem; 1991 Apr 09; 34(4):1447-54. PubMed ID: 2016722
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  • 5. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Thorndike J, Sirotnak FM.
    J Med Chem; 1988 Nov 09; 31(11):2164-9. PubMed ID: 3184124
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  • 6. Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase.
    Baldwin SW, Tse A, Gossett LS, Taylor EC, Rosowsky A, Shih C, Moran RG.
    Biochemistry; 1991 Feb 19; 30(7):1997-2006. PubMed ID: 1993209
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  • 8. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A, Galivan J, Beardsley GP, Bader H, O'Connor BM, Russello O, Moroson BA, DeYarman MT, Kerwar SS, Freisheim JH.
    Cancer Res; 1992 Apr 15; 52(8):2148-55. PubMed ID: 1313737
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  • 10. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR, Schornagel JH, Kathmann I, Jackman AL, Rosowsky A, Forsch RA, Hynes JB, Boyle FT, Peters GJ, Pinedo HM.
    Mol Pharmacol; 1995 Sep 15; 48(3):459-71. PubMed ID: 7565626
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  • 11. Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.
    Nair MG, Murthy BR, Patil SD, Kisliuk RL, Thorndike J, Gaumont Y, Ferone R, Duch DS, Edelstein MP.
    J Med Chem; 1989 Jun 15; 32(6):1277-83. PubMed ID: 2498518
    [Abstract] [Full Text] [Related]

  • 12. Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase.
    Sanghani SP, Moran RG.
    Biochemistry; 1997 Aug 26; 36(34):10506-16. PubMed ID: 9265631
    [Abstract] [Full Text] [Related]

  • 13. Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs.
    Habeck LL, Mendelsohn LG, Shih C, Taylor EC, Colman PD, Gossett LS, Leitner TA, Schultz RM, Andis SL, Moran RG.
    Mol Pharmacol; 1995 Aug 26; 48(2):326-33. PubMed ID: 7651366
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  • 14. Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase.
    Caperelli CA, Conigliaro J.
    J Med Chem; 1986 Oct 26; 29(10):2117-9. PubMed ID: 3761327
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  • 15. Synthesis and biological evaluation of N alpha-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine.
    Singh SK, Singer SC, Ferone R, Waters KA, Mullin RJ, Hynes JB.
    J Med Chem; 1992 May 29; 35(11):2002-6. PubMed ID: 1375963
    [Abstract] [Full Text] [Related]

  • 16. Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines.
    Faessel HM, Slocum HK, Rustum YM, Greco WR.
    Biochem Pharmacol; 1999 Mar 01; 57(5):567-77. PubMed ID: 9952321
    [Abstract] [Full Text] [Related]

  • 17. Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis.
    Itoh F, Russello O, Akimoto H, Beardsley GP.
    Cancer Chemother Pharmacol; 1994 Mar 01; 34(4):273-9. PubMed ID: 8033293
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  • 18. Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.
    Kelley JL, McLean EW, Cohn NK, Edelstein MP, Duch DS, Smith GK, Hanlon MH, Ferone R.
    J Med Chem; 1990 Feb 01; 33(2):561-7. PubMed ID: 2299624
    [Abstract] [Full Text] [Related]

  • 19. Tetrahydrohomofolate polyglutamates as inhibitors of thymidylate synthase and glycinamide ribonucleotide formyltransferase in Lactobacillus casei.
    Thorndike J, Kisliuk RL, Gaumont Y, Piper JR, Nair MG.
    Arch Biochem Biophys; 1990 Mar 01; 277(2):334-41. PubMed ID: 2106831
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  • 20. N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase.
    Caperelli CA.
    J Med Chem; 1987 Jul 01; 30(7):1254-6. PubMed ID: 3599031
    [Abstract] [Full Text] [Related]

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