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Journal Abstract Search

56 related items for PubMed ID: 15808471

  • 1. 2-(Arylmethyl)-3-substituted quinuclidines as selective alpha 7 nicotinic receptor ligands.
    Mazurov A, Klucik J, Miao L, Phillips TY, Seamans A, Schmitt JD, Hauser TA, Johnson RT, Miller C.
    Bioorg Med Chem Lett; 2005 Apr 15; 15(8):2073-7. PubMed ID: 15808471
    [Abstract] [Full Text] [Related]

  • 2. JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist.
    Feuerbach D, Nozulak J, Lingenhoehl K, McAllister K, Hoyer D.
    Neurosci Lett; 2007 Apr 06; 416(1):61-5. PubMed ID: 17314009
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  • 3. An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes.
    Marrero MB, Lucas R, Salet C, Hauser TA, Mazurov A, Lippiello PM, Bencherif M.
    J Pharmacol Exp Ther; 2010 Jan 06; 332(1):173-80. PubMed ID: 19786623
    [Abstract] [Full Text] [Related]

  • 4. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.
    Prickaerts J, van Goethem NP, Chesworth R, Shapiro G, Boess FG, Methfessel C, Reneerkens OA, Flood DG, Hilt D, Gawryl M, Bertrand S, Bertrand D, König G.
    Neuropharmacology; 2012 Feb 06; 62(2):1099-110. PubMed ID: 22085888
    [Abstract] [Full Text] [Related]

  • 5. Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
    Bunnelle WH, Tietje KR, Frost JM, Peters D, Ji J, Li T, Scanio MJ, Shi L, Anderson DJ, Dyhring T, Grønlien JH, Ween H, Thorin-Hagene K, Meyer MD.
    J Med Chem; 2009 Jul 23; 52(14):4126-41. PubMed ID: 19552432
    [Abstract] [Full Text] [Related]

  • 6. Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand.
    Tatsumi R, Fujio M, Satoh H, Katayama J, Takanashi S, Hashimoto K, Tanaka H.
    J Med Chem; 2005 Apr 07; 48(7):2678-86. PubMed ID: 15801858
    [Abstract] [Full Text] [Related]

  • 7. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.
    Bodnar AL, Cortes-Burgos LA, Cook KK, Dinh DM, Groppi VE, Hajos M, Higdon NR, Hoffmann WE, Hurst RS, Myers JK, Rogers BN, Wall TM, Wolfe ML, Wong E.
    J Med Chem; 2005 Feb 24; 48(4):905-8. PubMed ID: 15715459
    [Abstract] [Full Text] [Related]

  • 8. Differential coupling of alpha7 and non-alpha7 nicotinic acetylcholine receptors to calcium-induced calcium release and voltage-operated calcium channels in PC12 cells.
    Dickinson JA, Hanrott KE, Mok MH, Kew JN, Wonnacott S.
    J Neurochem; 2007 Feb 24; 100(4):1089-96. PubMed ID: 17181555
    [Abstract] [Full Text] [Related]

  • 9. Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands.
    Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS.
    J Org Chem; 2008 May 02; 73(9):3497-507. PubMed ID: 18363376
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  • 13. In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.
    Malysz J, Grønlien JH, Anderson DJ, Håkerud M, Thorin-Hagene K, Ween H, Wetterstrand C, Briggs CA, Faghih R, Bunnelle WH, Gopalakrishnan M.
    J Pharmacol Exp Ther; 2009 Jul 02; 330(1):257-67. PubMed ID: 19389923
    [Abstract] [Full Text] [Related]

  • 14. Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.
    Mortell KH, Schrimpf MR, Bunnelle WH, Anderson DJ, Gronlien JH, Hagene KT, Gopalakrishnan M.
    Bioorg Med Chem Lett; 2010 Jan 01; 20(1):104-7. PubMed ID: 19954975
    [Abstract] [Full Text] [Related]

  • 15. High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor.
    Baker SR, Boot J, Brunavs M, Dobson D, Green R, Hayhurst L, Keenan M, Wallace L.
    Bioorg Med Chem Lett; 2005 Nov 01; 15(21):4727-30. PubMed ID: 16165358
    [Abstract] [Full Text] [Related]

  • 16. Presynaptic alpha 7- and beta 2-containing nicotinic acetylcholine receptors modulate excitatory amino acid release from rat prefrontal cortex nerve terminals via distinct cellular mechanisms.
    Dickinson JA, Kew JN, Wonnacott S.
    Mol Pharmacol; 2008 Aug 01; 74(2):348-59. PubMed ID: 18445710
    [Abstract] [Full Text] [Related]

  • 17. Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.
    Mazurov AA, Kombo DC, Hauser TA, Miao L, Dull G, Genus JF, Fedorov NB, Benson L, Sidach S, Xiao Y, Hammond PS, James JW, Miller CH, Yohannes D.
    J Med Chem; 2012 Nov 26; 55(22):9793-809. PubMed ID: 23126648
    [Abstract] [Full Text] [Related]

  • 18. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
    Wishka DG, Walker DP, Yates KM, Reitz SC, Jia S, Myers JK, Olson KL, Jacobsen EJ, Wolfe ML, Groppi VE, Hanchar AJ, Thornburgh BA, Cortes-Burgos LA, Wong EH, Staton BA, Raub TJ, Higdon NR, Wall TM, Hurst RS, Walters RR, Hoffmann WE, Hajos M, Franklin S, Carey G, Gold LH, Cook KK, Sands SB, Zhao SX, Soglia JR, Kalgutkar AS, Arneric SP, Rogers BN.
    J Med Chem; 2006 Jul 13; 49(14):4425-36. PubMed ID: 16821801
    [Abstract] [Full Text] [Related]

  • 19. Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide).
    Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, Jow F, Kramer A, Bowlby MR, Randall A, Kowal D, Gilbert A, Comery TA, Larocque J, Soloveva V, Brown J, Roncarati R.
    J Pharmacol Exp Ther; 2009 Mar 13; 328(3):766-76. PubMed ID: 19050173
    [Abstract] [Full Text] [Related]

  • 20. Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.
    Ellison M, Gao F, Wang HL, Sine SM, McIntosh JM, Olivera BM.
    Biochemistry; 2004 Dec 28; 43(51):16019-26. PubMed ID: 15609996
    [Abstract] [Full Text] [Related]

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