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150 related items for PubMed ID: 15815973

  • 1. Comparative molecular dynamics simulations of HIV-1 integrase and the T66I/M154I mutant: binding modes and drug resistance to a diketo acid inhibitor.
    Brigo A, Lee KW, Fogolari F, Mustata GI, Briggs JM.
    Proteins; 2005 Jun 01; 59(4):723-41. PubMed ID: 15815973
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  • 2. Characterization and structural analysis of HIV-1 integrase conservation.
    Ceccherini-Silberstein F, Malet I, D'Arrigo R, Antinori A, Marcelin AG, Perno CF.
    AIDS Rev; 2009 Jun 01; 11(1):17-29. PubMed ID: 19290031
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  • 3. Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/M154I catalytic domain.
    Brigo A, Lee KW, Iurcu Mustata G, Briggs JM.
    Biophys J; 2005 May 01; 88(5):3072-82. PubMed ID: 15764656
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  • 4. Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant.
    Garvey EP, Schwartz B, Gartland MJ, Lang S, Halsey W, Sathe G, Carter HL, Weaver KL.
    Biochemistry; 2009 Feb 24; 48(7):1644-53. PubMed ID: 19178153
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  • 5. Human immunodeficiency virus type 1 (HIV-1) integrase: resistance to diketo acid integrase inhibitors impairs HIV-1 replication and integration and confers cross-resistance to L-chicoric acid.
    Lee DJ, Robinson WE.
    J Virol; 2004 Jun 24; 78(11):5835-47. PubMed ID: 15140981
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  • 7. Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase.
    Du L, Zhao YX, Yang LM, Zheng YT, Tang Y, Shen X, Jiang HL.
    Acta Pharmacol Sin; 2008 Oct 24; 29(10):1261-7. PubMed ID: 18817633
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  • 9. Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistance.
    Barreca ML, Lee KW, Chimirri A, Briggs JM.
    Biophys J; 2003 Mar 24; 84(3):1450-63. PubMed ID: 12609852
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  • 10. Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.
    Walker MA, Johnson T, Ma Z, Banville J, Remillard R, Kim O, Zhang Y, Staab A, Wong H, Torri A, Samanta H, Lin Z, Deminie C, Terry B, Krystal M, Meanwell N.
    Bioorg Med Chem Lett; 2006 Jun 01; 16(11):2920-4. PubMed ID: 16546383
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  • 12. Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).
    Marchand C, Johnson AA, Karki RG, Pais GC, Zhang X, Cowansage K, Patel TA, Nicklaus MC, Burke TR, Pommier Y.
    Mol Pharmacol; 2003 Sep 01; 64(3):600-9. PubMed ID: 12920196
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  • 14. Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.
    Grobler JA, Stillmock K, Hu B, Witmer M, Felock P, Espeseth AS, Wolfe A, Egbertson M, Bourgeois M, Melamed J, Wai JS, Young S, Vacca J, Hazuda DJ.
    Proc Natl Acad Sci U S A; 2002 May 14; 99(10):6661-6. PubMed ID: 11997448
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  • 15. Study on the inhibitory mechanism and binding mode of the hydroxycoumarin compound NSC158393 to HIV-1 integrase by molecular modeling.
    Liu M, Cong XJ, Li P, Tan JJ, Chen WZ, Wang CX.
    Biopolymers; 2009 Sep 14; 91(9):700-9. PubMed ID: 19382173
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  • 16. Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.
    Chen X, Tsiang M, Yu F, Hung M, Jones GS, Zeynalzadegan A, Qi X, Jin H, Kim CU, Swaminathan S, Chen JM.
    J Mol Biol; 2008 Jul 11; 380(3):504-19. PubMed ID: 18565342
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  • 18. Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance.
    Lataillade M, Chiarella J, Kozal MJ.
    Antivir Ther; 2007 Jul 11; 12(4):563-70. PubMed ID: 17668566
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