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1489 related items for PubMed ID: 15821750

  • 1. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
    Lea PM, Movsesyan VA, Faden AI.
    Br J Pharmacol; 2005 Jun; 145(4):527-34. PubMed ID: 15821750
    [Abstract] [Full Text] [Related]

  • 2. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
    O'Leary DM, Movsesyan V, Vicini S, Faden AI.
    Br J Pharmacol; 2000 Dec; 131(7):1429-37. PubMed ID: 11090117
    [Abstract] [Full Text] [Related]

  • 3. mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors.
    Movsesyan VA, O'Leary DM, Fan L, Bao W, Mullins PG, Knoblach SM, Faden AI.
    J Pharmacol Exp Ther; 2001 Jan; 296(1):41-7. PubMed ID: 11123360
    [Abstract] [Full Text] [Related]

  • 4. Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia.
    Bao WL, Williams AJ, Faden AI, Tortella FC.
    Brain Res; 2001 Dec 20; 922(2):173-9. PubMed ID: 11743947
    [Abstract] [Full Text] [Related]

  • 5. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
    Pisani A, Gubellini P, Bonsi P, Conquet F, Picconi B, Centonze D, Bernardi G, Calabresi P.
    Neuroscience; 2001 Dec 20; 106(3):579-87. PubMed ID: 11591458
    [Abstract] [Full Text] [Related]

  • 6. MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor.
    Movsesyan VA, Stoica BA, Faden AI.
    J Neurochem; 2004 Jun 20; 89(6):1528-36. PubMed ID: 15189356
    [Abstract] [Full Text] [Related]

  • 7. mGluR5 antagonist-induced psychoactive properties: MTEP drug discrimination, a pharmacologically selective non-NMDA effect with apparent lack of reinforcing properties.
    Swedberg MD, Ellgren M, Raboisson P.
    J Pharmacol Exp Ther; 2014 Apr 20; 349(1):155-64. PubMed ID: 24472725
    [Abstract] [Full Text] [Related]

  • 8. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles.
    Varty GB, Grilli M, Forlani A, Fredduzzi S, Grzelak ME, Guthrie DH, Hodgson RA, Lu SX, Nicolussi E, Pond AJ, Parker EM, Hunter JC, Higgins GA, Reggiani A, Bertorelli R.
    Psychopharmacology (Berl); 2005 Apr 20; 179(1):207-17. PubMed ID: 15682298
    [Abstract] [Full Text] [Related]

  • 9. The metabotropic glutamate mGluR5 receptor agonist CHPG stimulates food intake.
    Ploj K, Albery-Larsdotter S, Arlbrandt S, Kjaer MB, Skantze PM, Storlien LH.
    Neuroreport; 2010 Jul 14; 21(10):704-8. PubMed ID: 20505551
    [Abstract] [Full Text] [Related]

  • 10. Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents.
    Blaabjerg M, Fang L, Zimmer J, Baskys A.
    Exp Neurol; 2003 Oct 14; 183(2):573-80. PubMed ID: 14552898
    [Abstract] [Full Text] [Related]

  • 11. [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.
    Anderson JJ, Rao SP, Rowe B, Giracello DR, Holtz G, Chapman DF, Tehrani L, Bradbury MJ, Cosford ND, Varney MA.
    J Pharmacol Exp Ther; 2002 Dec 14; 303(3):1044-51. PubMed ID: 12438526
    [Abstract] [Full Text] [Related]

  • 12. Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus.
    Domin H, Zięba B, Gołembiowska K, Kowalska M, Dziubina A, Śmiałowska M.
    Pharmacol Rep; 2010 Dec 14; 62(6):1051-61. PubMed ID: 21273662
    [Abstract] [Full Text] [Related]

  • 13. Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists.
    Bespalov A, Dravolina O, Belozertseva I, Adamcio B, Zvartau E.
    Behav Pharmacol; 2006 Jun 14; 17(4):295-302. PubMed ID: 16914947
    [Abstract] [Full Text] [Related]

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  • 15. Preproenkephalin mRNA expression in rat dorsal striatum induced by selective activation of metabotropic glutamate receptor subtype-5.
    Parelkar NK, Wang JQ.
    Synapse; 2003 Mar 15; 47(4):255-61. PubMed ID: 12539198
    [Abstract] [Full Text] [Related]

  • 16. Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity.
    Popoli P, Pintor A, Tebano MT, Frank C, Pepponi R, Nazzicone V, Grieco R, Pèzzola A, Reggio R, Minghetti L, De Berardinis MA, Martire A, Potenza RL, Domenici MR, Massotti M.
    J Neurochem; 2004 Jun 15; 89(6):1479-89. PubMed ID: 15189351
    [Abstract] [Full Text] [Related]

  • 17. mGluR5 promotes the differentiation of rat neural progenitor cells into cholinergic neurons and activation of extracellular signal-related protein kinases.
    Zhao L, Jiao Q, Huang C, Hou N, Chen X, Zhang J, Yang P, Xu X, Song T, Liu Y.
    Neuroreport; 2014 Apr 16; 25(6):427-34. PubMed ID: 24670535
    [Abstract] [Full Text] [Related]

  • 18. The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures.
    Blaabjerg M, Kristensen BW, Bonde C, Zimmer J.
    Brain Res; 2001 Apr 13; 898(1):91-104. PubMed ID: 11292452
    [Abstract] [Full Text] [Related]

  • 19. Modulation of pyramidal cell output in the medial prefrontal cortex by mGluR5 interacting with CB1.
    Kiritoshi T, Sun H, Ren W, Stauffer SR, Lindsley CW, Conn PJ, Neugebauer V.
    Neuropharmacology; 2013 Mar 13; 66():170-8. PubMed ID: 22521499
    [Abstract] [Full Text] [Related]

  • 20. Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells.
    de Labra C, Rivadulla C, Cudeiro J.
    Eur J Neurosci; 2005 Jan 13; 21(2):403-10. PubMed ID: 15673439
    [Abstract] [Full Text] [Related]

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