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157 related items for PubMed ID: 15837754

  • 1. Cellular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia.
    Dai G, Chan KK, Liu S, Hoyt D, Whitman S, Klisovic M, Shen T, Caligiuri MA, Byrd J, Grever M, Marcucci G.
    Clin Cancer Res; 2005 Apr 15; 11(8):2998-3008. PubMed ID: 15837754
    [Abstract] [Full Text] [Related]

  • 2. Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity.
    Marcucci G, Stock W, Dai G, Klisovic RB, Liu S, Klisovic MI, Blum W, Kefauver C, Sher DA, Green M, Moran M, Maharry K, Novick S, Bloomfield CD, Zwiebel JA, Larson RA, Grever MR, Chan KK, Byrd JC.
    J Clin Oncol; 2005 May 20; 23(15):3404-11. PubMed ID: 15824414
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  • 4. Cationic lipids enhanced cellular uptake and activity of bcl-2 antisense oligodeoxynucleotide G3139 in HL-60 cells.
    Zhu YG, Zhuo GS, Chen ZZ, Chen XC.
    Acta Pharmacol Sin; 2001 Nov 20; 22(11):1007-12. PubMed ID: 11749792
    [Abstract] [Full Text] [Related]

  • 5. G3139 induces cell death by caspase-dependent and -independent apoptosis on human melanoma cell lines.
    Nakamura S, Inui M, Kamei T, Nakase M, Okumura K, Tagawa T.
    Oncol Rep; 2006 Jun 20; 15(6):1563-8. PubMed ID: 16685396
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  • 7. Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer.
    Morris MJ, Tong WP, Cordon-Cardo C, Drobnjak M, Kelly WK, Slovin SF, Terry KL, Siedlecki K, Swanson P, Rafi M, DiPaola RS, Rosen N, Scher HI.
    Clin Cancer Res; 2002 Mar 20; 8(3):679-83. PubMed ID: 11895895
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  • 8. G3139 antisense oligonucleotide directed against antiapoptotic Bcl-2 enhances doxorubicin cytotoxicity in the FU-SY-1 synovial sarcoma cell line.
    Joyner DE, Albritton KH, Bastar JD, Randall RL.
    J Orthop Res; 2006 Mar 20; 24(3):474-80. PubMed ID: 16450387
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  • 10. Bcl-2 protein in 518A2 melanoma cells in vivo and in vitro.
    Benimetskaya L, Ayyanar K, Kornblum N, Castanotto D, Rossi J, Wu S, Lai J, Brown BD, Popova N, Miller P, McMicken H, Chen Y, Stein CA.
    Clin Cancer Res; 2006 Aug 15; 12(16):4940-8. PubMed ID: 16914583
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  • 11. Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein.
    van de Donk NW, Kamphuis MM, van Dijk M, Borst HP, Bloem AC, Lokhorst HM.
    Leukemia; 2003 Jan 15; 17(1):211-9. PubMed ID: 12529680
    [Abstract] [Full Text] [Related]

  • 12. Gene profiling study of G3139- and Bcl-2-targeting siRNAs identifies a unique G3139 molecular signature.
    Anderson EM, Miller P, Ilsley D, Marshall W, Khvorova A, Stein CA, Benimetskaya L.
    Cancer Gene Ther; 2006 Apr 15; 13(4):406-14. PubMed ID: 16195754
    [Abstract] [Full Text] [Related]

  • 13. Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor-targeted liposomes.
    Chiu SJ, Liu S, Perrotti D, Marcucci G, Lee RJ.
    J Control Release; 2006 May 15; 112(2):199-207. PubMed ID: 16564596
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  • 14. Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and -gamma.
    Benimetskaya L, Wittenberger T, Stein CA, Hofmann HP, Weller C, Lai JC, Miller P, Gekeler V.
    Clin Cancer Res; 2004 Jun 01; 10(11):3678-88. PubMed ID: 15173074
    [Abstract] [Full Text] [Related]

  • 15. Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry.
    Dai G, Wei X, Liu Z, Liu S, Marcucci G, Chan KK.
    J Chromatogr B Analyt Technol Biomed Life Sci; 2005 Oct 25; 825(2):201-13. PubMed ID: 16111926
    [Abstract] [Full Text] [Related]

  • 16. Induction of apoptosis by G3139 in melanoma cells.
    Benimetskaya L, Lai JC, Khvorova A, Wu S, Miller P, Stein CA.
    Ann N Y Acad Sci; 2005 Nov 25; 1058():235-45. PubMed ID: 16394140
    [Abstract] [Full Text] [Related]

  • 17. A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices.
    Wei X, Dai G, Marcucci G, Liu Z, Hoyt D, Blum W, Chan KK.
    Pharm Res; 2006 Jun 25; 23(6):1251-64. PubMed ID: 16718617
    [Abstract] [Full Text] [Related]

  • 18. Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia.
    Marcucci G, Byrd JC, Dai G, Klisovic MI, Kourlas PJ, Young DC, Cataland SR, Fisher DB, Lucas D, Chan KK, Porcu P, Lin ZP, Farag SF, Frankel SR, Zwiebel JA, Kraut EH, Balcerzak SP, Bloomfield CD, Grever MR, Caligiuri MA.
    Blood; 2003 Jan 15; 101(2):425-32. PubMed ID: 12393493
    [Abstract] [Full Text] [Related]

  • 19. Oblimersen sodium (G3139 Bcl-2 antisense oligonucleotide) therapy in Waldenstrom's macroglobulinemia: a targeted approach to enhance apoptosis.
    Frankel SR.
    Semin Oncol; 2003 Apr 15; 30(2):300-4. PubMed ID: 12720157
    [Abstract] [Full Text] [Related]

  • 20. Modulation of malignant B cell activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN.
    Jahrsdörfer B, Jox R, Mühlenhoff L, Tschoep K, Krug A, Rothenfusser S, Meinhardt G, Emmerich B, Endres S, Hartmann G.
    J Leukoc Biol; 2002 Jul 15; 72(1):83-92. PubMed ID: 12101266
    [Abstract] [Full Text] [Related]

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