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Journal Abstract Search

205 related items for PubMed ID: 15848772

  • 1. Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
    Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2005 May 16; 13(10):3593-9. PubMed ID: 15848772
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Cheng H, Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2005 May 16; 13(10):3577-85. PubMed ID: 15848770
    [Abstract] [Full Text] [Related]

  • 3. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
    Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2002 Aug 16; 10(8):2739-49. PubMed ID: 12057663
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF.
    Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2005 May 16; 13(10):3587-92. PubMed ID: 15848771
    [Abstract] [Full Text] [Related]

  • 5. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4511-21. PubMed ID: 13129587
    [Abstract] [Full Text] [Related]

  • 6. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4503-9. PubMed ID: 13129586
    [Abstract] [Full Text] [Related]

  • 7. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
    Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA.
    Biochemistry; 2003 May 27; 42(20):6043-56. PubMed ID: 12755606
    [Abstract] [Full Text] [Related]

  • 8. Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase.
    Boger DL, Haynes NE, Warren MS, Ramcharan J, Marolewski AE, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 27; 5(9):1847-52. PubMed ID: 9354240
    [Abstract] [Full Text] [Related]

  • 9. 10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase.
    Boger DL, Haynes NE, Kitos PA, Warren MS, Ramcharan J, Marolewski AE, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 27; 5(9):1817-30. PubMed ID: 9354237
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Boger DL, Marsilje TH, Castro RA, Hedrick MP, Jin Q, Baker SJ, Shim JH, Benkovic SJ.
    Bioorg Med Chem Lett; 2000 Jul 03; 10(13):1471-5. PubMed ID: 10888335
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4487-501. PubMed ID: 13129585
    [Abstract] [Full Text] [Related]

  • 12. Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition.
    Varney MD, Palmer CL, Romines WH, Boritzki T, Margosiak SA, Almassy R, Janson CA, Bartlett C, Howland EJ, Ferre R.
    J Med Chem; 1997 Aug 01; 40(16):2502-24. PubMed ID: 9258357
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.
    Kelley JL, McLean EW, Cohn NK, Edelstein MP, Duch DS, Smith GK, Hanlon MH, Ferone R.
    J Med Chem; 1990 Feb 01; 33(2):561-7. PubMed ID: 2299624
    [Abstract] [Full Text] [Related]

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  • 15. Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase.
    Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 01; 5(9):1839-46. PubMed ID: 9354239
    [Abstract] [Full Text] [Related]

  • 16. A multisubstrate adduct inhibitor of AICAR transformylase.
    Wall M, Shim JH, Benkovic SJ.
    J Med Chem; 1999 Sep 09; 42(18):3421-4. PubMed ID: 10479275
    [No Abstract] [Full Text] [Related]

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  • 19. Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization.
    Capps KJ, Humiston J, Dominique R, Hwang I, Boger DL.
    Bioorg Med Chem Lett; 2005 Jun 02; 15(11):2840-4. PubMed ID: 15911265
    [Abstract] [Full Text] [Related]

  • 20. Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.
    DeMartino JK, Hwang I, Connelly S, Wilson IA, Boger DL.
    J Med Chem; 2008 Sep 11; 51(17):5441-8. PubMed ID: 18686942
    [Abstract] [Full Text] [Related]

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