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Journal Abstract Search

169 related items for PubMed ID: 15863327

  • 1. 5-Lipoxygenase inhibitors: convenient synthesis of 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues.
    Mano T, Stevens RW, Okumura Y, Kawai M, Okumura T, Sakakibara M.
    Bioorg Med Chem Lett; 2005 May 16; 15(10):2611-5. PubMed ID: 15863327
    [Abstract] [Full Text] [Related]

  • 2. 4-[5-Fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]phenyl]-3,4,5,6- tetrahydro-2H-pyran-4-carboxamide, an orally active inhibitor of 5-lipoxygenase with improved pharmacokinetic and toxicology characteristics.
    Mano T, Okumura Y, Sakakibara M, Okumura T, Tamura T, Miyamoto K, Stevens RW.
    J Med Chem; 2004 Jan 29; 47(3):720-5. PubMed ID: 14736252
    [Abstract] [Full Text] [Related]

  • 3. 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.
    Bhatia PA, Brooks CD, Basha A, Ratajczyk JD, Gunn BP, Bouska JB, Lanni C, Young PR, Bell RL, Carter GW.
    J Med Chem; 1996 Sep 27; 39(20):3938-50. PubMed ID: 8831760
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  • 4. Structure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase.
    Crawley GC, Bird TG, Bruneau P, Dowell RI, Edwards PN, Foster SJ, Girodeau JM, McMillan RM, Walker ER, Waterson D.
    J Lipid Mediat; 1993 Sep 27; 6(1-3):249-57. PubMed ID: 8395247
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  • 5. Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.
    Doiron J, Boudreau LH, Picot N, Villebonet B, Surette ME, Touaibia M.
    Bioorg Med Chem Lett; 2009 Feb 15; 19(4):1118-21. PubMed ID: 19152786
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  • 6. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7898-909. PubMed ID: 16904331
    [Abstract] [Full Text] [Related]

  • 7. 6-substituted purines as inhibitors of 15-lipoxygenase; a structure-activity study.
    Bråthe A, Gundersen LL, Malterud KE, Rise F.
    Arch Pharm (Weinheim); 2005 Apr 01; 338(4):159-66. PubMed ID: 15864785
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  • 8. Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.
    Delorme D, Ducharme Y, Brideau C, Chan CC, Chauret N, Desmarais S, Dubé D, Falgueyret JP, Fortin R, Guay J, Hamel P, Jones TR, Lépine C, Li C, McAuliffe M, McFarlane CS, Nicoll-Griffith DA, Riendeau D, Yergey JA, Girard Y.
    J Med Chem; 1996 Sep 27; 39(20):3951-70. PubMed ID: 8831761
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.
    Barzen S, Rödl CB, Lill A, Steinhilber D, Stark H, Hofmann B.
    Bioorg Med Chem; 2012 Jun 01; 20(11):3575-83. PubMed ID: 22551629
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases.
    Moreau A, Chen QH, Praveen Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7716-27. PubMed ID: 16931030
    [Abstract] [Full Text] [Related]

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  • 12. Optimization of imidazole 5-lipoxygenase inhibitors and selection and synthesis of a development candidate.
    Mano T, Stevens RW, Ando K, Kawai M, Kawamura K, Nakao K, Okumura Y, Okumura T, Sakakibara M, Miyamoto K, Tamura T.
    Chem Pharm Bull (Tokyo); 2005 Aug 01; 53(8):965-73. PubMed ID: 16079529
    [Abstract] [Full Text] [Related]

  • 13. A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors.
    Hofmann B, Barzen S, Rödl CB, Kiehl A, Borig J, Zivković A, Stark H, Schneider G, Steinhilber D.
    J Med Chem; 2011 Mar 24; 54(6):1943-7. PubMed ID: 21341744
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  • 16. SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.
    Hieke M, Rödl CB, Wisniewska JM, la Buscató E, Stark H, Schubert-Zsilavecz M, Steinhilber D, Hofmann B, Proschak E.
    Bioorg Med Chem Lett; 2012 Mar 01; 22(5):1969-75. PubMed ID: 22326163
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  • 17. Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase.
    Mano T, Stevens RW, Ando K, Nakao K, Okumura Y, Sakakibara M, Okumura T, Tamura T, Miyamoto K.
    Bioorg Med Chem; 2003 Sep 01; 11(18):3879-87. PubMed ID: 12927848
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  • 18. Synthesis of new sulfonamides as lipoxygenase inhibitors.
    Mustafa G, Khan IU, Ashraf M, Afzal I, Shahzad SA, Shafiq M.
    Bioorg Med Chem; 2012 Apr 15; 20(8):2535-9. PubMed ID: 22436389
    [Abstract] [Full Text] [Related]

  • 19. Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase[sol ]cyclooxygenase.
    Schneider I, Bucar F.
    Phytother Res; 2005 Feb 15; 19(2):81-102. PubMed ID: 15852496
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