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236 related items for PubMed ID: 15863497

  • 1. Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.
    Sung JY, Park SM, Lee CH, Um JW, Lee HJ, Kim J, Oh YJ, Lee ST, Paik SR, Chung KC.
    J Biol Chem; 2005 Jul 01; 280(26):25216-24. PubMed ID: 15863497
    [Abstract] [Full Text] [Related]

  • 2. Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death.
    Choi DH, Kim YJ, Kim YG, Joh TH, Beal MF, Kim YS.
    J Biol Chem; 2011 Apr 22; 286(16):14168-77. PubMed ID: 21330369
    [Abstract] [Full Text] [Related]

  • 3. Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases.
    Levin J, Giese A, Boetzel K, Israel L, Högen T, Nübling G, Kretzschmar H, Lorenzl S.
    Exp Neurol; 2009 Jan 22; 215(1):201-8. PubMed ID: 19022250
    [Abstract] [Full Text] [Related]

  • 4. Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease.
    Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
    J Neurochem; 2004 Oct 22; 91(2):451-61. PubMed ID: 15447678
    [Abstract] [Full Text] [Related]

  • 5. alpha-Synuclein affects the MAPK pathway and accelerates cell death.
    Iwata A, Maruyama M, Kanazawa I, Nukina N.
    J Biol Chem; 2001 Nov 30; 276(48):45320-9. PubMed ID: 11560921
    [Abstract] [Full Text] [Related]

  • 6. Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
    Conway KA, Harper JD, Lansbury PT.
    Biochemistry; 2000 Mar 14; 39(10):2552-63. PubMed ID: 10704204
    [Abstract] [Full Text] [Related]

  • 7. Copper(II)-induced self-oligomerization of alpha-synuclein.
    Paik SR, Shin HJ, Lee JH, Chang CS, Kim J.
    Biochem J; 1999 Jun 15; 340 ( Pt 3)(Pt 3):821-8. PubMed ID: 10359669
    [Abstract] [Full Text] [Related]

  • 8. Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury.
    Kholodilov NG, Neystat M, Oo TF, Lo SE, Larsen KE, Sulzer D, Burke RE.
    J Neurochem; 1999 Dec 15; 73(6):2586-99. PubMed ID: 10582622
    [Abstract] [Full Text] [Related]

  • 9. Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.
    Culvenor JG, McLean CA, Cutt S, Campbell BC, Maher F, Jäkälä P, Hartmann T, Beyreuther K, Masters CL, Li QX.
    Am J Pathol; 1999 Oct 15; 155(4):1173-81. PubMed ID: 10514400
    [Abstract] [Full Text] [Related]

  • 10. Incubation with Cu(II) and Zn(II) salts enhances MALDI-TOF mass spectra of amyloid-beta and α-synuclein toward in vivo analysis.
    Kelley AR, Colley ME, Perry G, Bach SBH.
    J Mass Spectrom; 2018 Feb 15; 53(2):162-171. PubMed ID: 29111606
    [Abstract] [Full Text] [Related]

  • 11. Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.
    Junn E, Mouradian MM.
    Neurosci Lett; 2002 Mar 08; 320(3):146-50. PubMed ID: 11852183
    [Abstract] [Full Text] [Related]

  • 12. Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease.
    Tabner BJ, Turnbull S, El-Agnaf OM, Allsop D.
    Free Radic Biol Med; 2002 Jun 01; 32(11):1076-83. PubMed ID: 12031892
    [Abstract] [Full Text] [Related]

  • 13. Toxicity of non-abeta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils.
    Bodles AM, Guthrie DJ, Harriott P, Campbell P, Irvine GB.
    Eur J Biochem; 2000 Apr 01; 267(8):2186-94. PubMed ID: 10759841
    [Abstract] [Full Text] [Related]

  • 14. Alpha-synuclein and Parkinson's disease.
    Lücking CB, Brice A.
    Cell Mol Life Sci; 2000 Dec 01; 57(13-14):1894-908. PubMed ID: 11215516
    [Abstract] [Full Text] [Related]

  • 15. Differential cytotoxicity of dopamine and H2O2 in a human neuroblastoma divided cell line transfected with alpha-synuclein and its familial Parkinson's disease-linked mutants.
    Wersinger C, Sidhu A.
    Neurosci Lett; 2003 May 15; 342(1-2):124-8. PubMed ID: 12727333
    [Abstract] [Full Text] [Related]

  • 16. Cell cycle aberrations by alpha-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies.
    Lee SS, Kim YM, Junn E, Lee G, Park KH, Tanaka M, Ronchetti RD, Quezado MM, Mouradian MM.
    Neurobiol Aging; 2003 Sep 15; 24(5):687-96. PubMed ID: 12885576
    [Abstract] [Full Text] [Related]

  • 17. Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.
    Hashimoto M, Rockenstein E, Crews L, Masliah E.
    Neuromolecular Med; 2003 Sep 15; 4(1-2):21-36. PubMed ID: 14528050
    [Abstract] [Full Text] [Related]

  • 18. Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.
    Bayer TA, Jäkälä P, Hartmann T, Havas L, McLean C, Culvenor JG, Li QX, Masters CL, Falkai P, Beyreuther K.
    Neurosci Lett; 1999 May 14; 266(3):213-6. PubMed ID: 10465711
    [Abstract] [Full Text] [Related]

  • 19. Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.
    Zhou W, Hurlbert MS, Schaack J, Prasad KN, Freed CR.
    Brain Res; 2000 Jun 02; 866(1-2):33-43. PubMed ID: 10825478
    [Abstract] [Full Text] [Related]

  • 20. MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.
    Kowall NW, Hantraye P, Brouillet E, Beal MF, McKee AC, Ferrante RJ.
    Neuroreport; 2000 Jan 17; 11(1):211-3. PubMed ID: 10683860
    [Abstract] [Full Text] [Related]

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