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Journal Abstract Search

237 related items for PubMed ID: 15887963

  • 1. AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase.
    Silber K, Heidler P, Kurz T, Klebe G.
    J Med Chem; 2005 May 19; 48(10):3547-63. PubMed ID: 15887963
    [Abstract] [Full Text] [Related]

  • 2. The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
    Mac Sweeney A, Lange R, Fernandes RP, Schulz H, Dale GE, Douangamath A, Proteau PJ, Oefner C.
    J Mol Biol; 2005 Jan 07; 345(1):115-27. PubMed ID: 15567415
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Andaloussi M, Henriksson LM, Więckowska A, Lindh M, Björkelid C, Larsson AM, Suresh S, Iyer H, Srinivasa BR, Bergfors T, Unge T, Mowbray SL, Larhed M, Jones TA, Karlén A.
    J Med Chem; 2011 Jul 28; 54(14):4964-76. PubMed ID: 21678907
    [Abstract] [Full Text] [Related]

  • 4. Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
    Giessmann D, Heidler P, Haemers T, Van Calenbergh S, Reichenberg A, Jomaa H, Weidemeyer C, Sanderbrand S, Wiesner J, Link A.
    Chem Biodivers; 2008 Apr 28; 5(4):643-56. PubMed ID: 18421757
    [Abstract] [Full Text] [Related]

  • 5. Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr).
    Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Gräwert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T.
    J Med Chem; 2011 Oct 13; 54(19):6796-802. PubMed ID: 21866890
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors.
    Bodill T, Conibear AC, Blatch GL, Lobb KA, Kaye PT.
    Bioorg Med Chem; 2011 Feb 01; 19(3):1321-7. PubMed ID: 21216609
    [Abstract] [Full Text] [Related]

  • 7. Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase.
    Perruchon J, Ortmann R, Altenkämper M, Silber K, Wiesner J, Jomaa H, Klebe G, Schlitzer M.
    ChemMedChem; 2008 Aug 01; 3(8):1232-41. PubMed ID: 18470849
    [Abstract] [Full Text] [Related]

  • 8. Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes.
    Yajima S, Hara K, Sanders JM, Yin F, Ohsawa K, Wiesner J, Jomaa H, Oldfield E.
    J Am Chem Soc; 2004 Sep 08; 126(35):10824-5. PubMed ID: 15339150
    [Abstract] [Full Text] [Related]

  • 9. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Mercklé L, de Andrés-Gómez A, Dick B, Cox RJ, Godfrey CR.
    Chembiochem; 2005 Oct 08; 6(10):1866-74. PubMed ID: 16116659
    [Abstract] [Full Text] [Related]

  • 10. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview.
    Proteau PJ.
    Bioorg Chem; 2004 Dec 08; 32(6):483-93. PubMed ID: 15530989
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors.
    Devreux V, Wiesner J, Jomaa H, Van der Eycken J, Van Calenbergh S.
    Bioorg Med Chem Lett; 2007 Sep 01; 17(17):4920-3. PubMed ID: 17583502
    [Abstract] [Full Text] [Related]

  • 12. Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.
    Takenoya M, Ohtaki A, Noguchi K, Endo K, Sasaki Y, Ohsawa K, Yajima S, Yohda M.
    J Struct Biol; 2010 Jun 01; 170(3):532-9. PubMed ID: 20353826
    [Abstract] [Full Text] [Related]

  • 13. Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation.
    Phaosiri C, Proteau PJ.
    Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5309-12. PubMed ID: 15454217
    [Abstract] [Full Text] [Related]

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  • 15. Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues.
    Ortmann R, Wiesner J, Silber K, Klebe G, Jomaa H, Schlitzer M.
    Arch Pharm (Weinheim); 2007 Sep 01; 340(9):483-90. PubMed ID: 17806130
    [Abstract] [Full Text] [Related]

  • 16. Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Deng L, Sundriyal S, Rubio V, Shi ZZ, Song Y.
    J Med Chem; 2009 Nov 12; 52(21):6539-42. PubMed ID: 19888756
    [Abstract] [Full Text] [Related]

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  • 18. NMR studies of DOXP reductoisomerase and its inhibitor complex.
    Englert NE, Richter C, Wiesner J, Hintz M, Jomaa H, Schwalbe H.
    Chembiochem; 2011 Feb 11; 12(3):468-76. PubMed ID: 21290548
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors.
    Devreux V, Wiesner J, Goeman JL, Van der Eycken J, Jomaa H, Van Calenbergh S.
    J Med Chem; 2006 Apr 20; 49(8):2656-60. PubMed ID: 16610809
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of isoprene biosynthesis pathway enzymes by phosphonates, bisphosphonates, and diphosphates.
    Cheng F, Oldfield E.
    J Med Chem; 2004 Oct 07; 47(21):5149-58. PubMed ID: 15456258
    [Abstract] [Full Text] [Related]

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