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218 related items for PubMed ID: 15909996

  • 1. Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
    Mishizen-Eberz AJ, Norris EH, Giasson BI, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR.
    Biochemistry; 2005 May 31; 44(21):7818-29. PubMed ID: 15909996
    [Abstract] [Full Text] [Related]

  • 2. Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.
    Kotzbauer PT, Giasson BI, Kravitz AV, Golbe LI, Mark MH, Trojanowski JQ, Lee VM.
    Exp Neurol; 2004 Jun 31; 187(2):279-88. PubMed ID: 15144854
    [Abstract] [Full Text] [Related]

  • 3. Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.
    Murray IV, Giasson BI, Quinn SM, Koppaka V, Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee VM.
    Biochemistry; 2003 Jul 22; 42(28):8530-40. PubMed ID: 12859200
    [Abstract] [Full Text] [Related]

  • 4. Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro.
    Mishizen-Eberz AJ, Guttmann RP, Giasson BI, Day GA, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR.
    J Neurochem; 2003 Aug 22; 86(4):836-47. PubMed ID: 12887682
    [Abstract] [Full Text] [Related]

  • 5. Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.
    Hodara R, Norris EH, Giasson BI, Mishizen-Eberz AJ, Lynch DR, Lee VM, Ischiropoulos H.
    J Biol Chem; 2004 Nov 12; 279(46):47746-53. PubMed ID: 15364911
    [Abstract] [Full Text] [Related]

  • 6. PA700, the regulatory complex of the 26S proteasome, interferes with alpha-synuclein assembly.
    Ghee M, Melki R, Michot N, Mallet J.
    FEBS J; 2005 Aug 12; 272(16):4023-33. PubMed ID: 16098186
    [Abstract] [Full Text] [Related]

  • 7. A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein.
    Du HN, Tang L, Luo XY, Li HT, Hu J, Zhou JW, Hu HY.
    Biochemistry; 2003 Jul 29; 42(29):8870-8. PubMed ID: 12873148
    [Abstract] [Full Text] [Related]

  • 8. A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed alpha-synuclein.
    Zhou C, Emadi S, Sierks MR, Messer A.
    Mol Ther; 2004 Dec 29; 10(6):1023-31. PubMed ID: 15564134
    [Abstract] [Full Text] [Related]

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  • 10. Initiation and synergistic fibrillization of tau and alpha-synuclein.
    Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM.
    Science; 2003 Apr 25; 300(5619):636-40. PubMed ID: 12714745
    [Abstract] [Full Text] [Related]

  • 11. Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity.
    Li W, Lee MK.
    J Neurochem; 2005 Jun 25; 93(6):1542-50. PubMed ID: 15935070
    [Abstract] [Full Text] [Related]

  • 12. A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.
    El-Agnaf OM, Paleologou KE, Greer B, Abogrein AM, King JE, Salem SA, Fullwood NJ, Benson FE, Hewitt R, Ford KJ, Martin FL, Harriott P, Cookson MR, Allsop D.
    FASEB J; 2004 Aug 25; 18(11):1315-7. PubMed ID: 15180968
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of alpha-synuclein fibrillization by dopamine analogs via reaction with the amino groups of alpha-synuclein. Implication for dopaminergic neurodegeneration.
    Li HT, Lin DH, Luo XY, Zhang F, Ji LN, Du HN, Song GQ, Hu J, Zhou JW, Hu HY.
    FEBS J; 2005 Jul 25; 272(14):3661-72. PubMed ID: 16008565
    [Abstract] [Full Text] [Related]

  • 14. Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease.
    Flower TR, Chesnokova LS, Froelich CA, Dixon C, Witt SN.
    J Mol Biol; 2005 Sep 02; 351(5):1081-100. PubMed ID: 16051265
    [Abstract] [Full Text] [Related]

  • 15. Rapid self-assembly of alpha-synuclein observed by in situ atomic force microscopy.
    Hoyer W, Cherny D, Subramaniam V, Jovin TM.
    J Mol Biol; 2004 Jun 25; 340(1):127-39. PubMed ID: 15184027
    [Abstract] [Full Text] [Related]

  • 16. Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments.
    Emadi S, Liu R, Yuan B, Schulz P, McAllister C, Lyubchenko Y, Messer A, Sierks MR.
    Biochemistry; 2004 Mar 16; 43(10):2871-8. PubMed ID: 15005622
    [Abstract] [Full Text] [Related]

  • 17. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.
    Duda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ.
    Ann Neurol; 2002 Aug 16; 52(2):205-10. PubMed ID: 12210791
    [Abstract] [Full Text] [Related]

  • 18. Nuclear localization of alpha-synuclein and its interaction with histones.
    Goers J, Manning-Bog AB, McCormack AL, Millett IS, Doniach S, Di Monte DA, Uversky VN, Fink AL.
    Biochemistry; 2003 Jul 22; 42(28):8465-71. PubMed ID: 12859192
    [Abstract] [Full Text] [Related]

  • 19. Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors.
    Luk KC, Hyde EG, Trojanowski JQ, Lee VM.
    Biochemistry; 2007 Nov 06; 46(44):12522-9. PubMed ID: 17927212
    [Abstract] [Full Text] [Related]

  • 20. Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.
    Xie YY, Zhou CJ, Zhou ZR, Hong J, Che MX, Fu QS, Song AX, Lin DH, Hu HY.
    FASEB J; 2010 Jan 06; 24(1):196-205. PubMed ID: 19762560
    [Abstract] [Full Text] [Related]

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