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Journal Abstract Search

516 related items for PubMed ID: 15916425

  • 1. Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.
    Wang J, Jin Y, Rapp KL, Bennett M, Schinazi RF, Chu CK.
    J Med Chem; 2005 Jun 02; 48(11):3736-48. PubMed ID: 15916425
    [Abstract] [Full Text] [Related]

  • 2. l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance.
    Chong Y, Gumina G, Mathew JS, Schinazi RF, Chu CK.
    J Med Chem; 2003 Jul 17; 46(15):3245-56. PubMed ID: 12852755
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents.
    Zhu W, Chong Y, Choo H, Mathews J, Schinazi RF, Chu CK.
    J Med Chem; 2004 Mar 25; 47(7):1631-40. PubMed ID: 15027854
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
    Choo H, Chong Y, Choi Y, Mathew J, Schinazi RF, Chu CK.
    J Med Chem; 2003 Jan 30; 46(3):389-98. PubMed ID: 12540238
    [Abstract] [Full Text] [Related]

  • 5. D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.
    Wang J, Jin Y, Rapp KL, Schinazi RF, Chu CK.
    J Med Chem; 2007 Apr 19; 50(8):1828-39. PubMed ID: 17373782
    [Abstract] [Full Text] [Related]

  • 6. Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents.
    Zhou W, Gumina G, Chong Y, Wang J, Schinazi RF, Chu CK.
    J Med Chem; 2004 Jun 17; 47(13):3399-408. PubMed ID: 15189036
    [Abstract] [Full Text] [Related]

  • 7. Molecular mechanism of dioxolane nucleosides against 3TC resistant M184V mutant HIV.
    Chong Y, Chu CK.
    Antiviral Res; 2004 Jul 17; 63(1):7-13. PubMed ID: 15196815
    [Abstract] [Full Text] [Related]

  • 8. A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides.
    Siddiqui MA, Hughes SH, Boyer PL, Mitsuya H, Van QN, George C, Sarafinanos SG, Marquez VE.
    J Med Chem; 2004 Oct 07; 47(21):5041-8. PubMed ID: 15456247
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
    Shi J, McAtee JJ, Schlueter Wirtz S, Tharnish P, Juodawlkis A, Liotta DC, Schinazi RF.
    J Med Chem; 1999 Mar 11; 42(5):859-67. PubMed ID: 10072683
    [Abstract] [Full Text] [Related]

  • 10. Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
    Chong Y, Choo H, Choi Y, Mathew J, Schinazi RF, Chu CK.
    J Med Chem; 2002 Oct 24; 45(22):4888-98. PubMed ID: 12383014
    [Abstract] [Full Text] [Related]

  • 11. 2'-Fluoro-4'-thio-2',3'-unsaturated nucleosides: anti-HIV activity, resistance profile, and molecular modeling studies.
    Chong Y, Choo H, Schinazi RF, Chu CK.
    Nucleosides Nucleotides Nucleic Acids; 2003 Oct 24; 22(5-8):611-5. PubMed ID: 14565238
    [Abstract] [Full Text] [Related]

  • 12. Asymmetric synthesis and antiviral activities of L-carbocyclic 2', 3'-didehydro-2',3'-dideoxy and 2',3'-dideoxy nucleosides.
    Wang P, Gullen B, Newton MG, Cheng YC, Schinazi RF, Chu CK.
    J Med Chem; 1999 Aug 26; 42(17):3390-9. PubMed ID: 10464025
    [Abstract] [Full Text] [Related]

  • 13. The role of 2',3'-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V).
    Choo H, Chong Y, Chu CK.
    Bioorg Med Chem Lett; 2003 Jun 16; 13(12):1993-6. PubMed ID: 12781181
    [Abstract] [Full Text] [Related]

  • 14. Stereoselective synthesis of D- and L-carbocyclic nucleosides by enzymatically catalyzed kinetic resolution.
    Mahler M, Reichardt B, Hartjen P, van Lunzen J, Meier C.
    Chemistry; 2012 Aug 27; 18(35):11046-62. PubMed ID: 22829408
    [Abstract] [Full Text] [Related]

  • 15. Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism.
    Chu CK, Yadav V, Chong YH, Schinazi RF.
    J Med Chem; 2005 Jun 16; 48(12):3949-52. PubMed ID: 15943470
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and antiviral activity of C-5 substituted beta-D- and beta-L-D4T analogues.
    Delbederi Z, Fossey C, Fontaine G, Benzaria S, Gavriliu D, Ciurea A, Lelong B, Ladurée D, Aubertin AM, Kirn A.
    Nucleosides Nucleotides Nucleic Acids; 2000 Sep 16; 19(9):1441-61. PubMed ID: 11092314
    [Abstract] [Full Text] [Related]

  • 17. Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
    Fattorusso C, Gemma S, Butini S, Huleatt P, Catalanotti B, Persico M, De Angelis M, Fiorini I, Nacci V, Ramunno A, Rodriquez M, Greco G, Novellino E, Bergamini A, Marini S, Coletta M, Maga G, Spadari S, Campiani G.
    J Med Chem; 2005 Nov 17; 48(23):7153-65. PubMed ID: 16279773
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2', 3'-unsaturated L-nucleosides.
    Lee K, Choi Y, Gullen E, Schlueter-Wirtz S, Schinazi RF, Cheng YC, Chu CK.
    J Med Chem; 1999 Apr 08; 42(7):1320-8. PubMed ID: 10197975
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and anti-HIV-1 evaluation of phosphonates which mimic the 5'-monophosphate of 4'-branched 2',3'-didehydro-2',3'-dideoxy nucleosides.
    Kubota Y, Ishizaki N, Haraguchi K, Hamasaki T, Baba M, Tanaka H.
    Bioorg Med Chem; 2010 Oct 15; 18(20):7186-92. PubMed ID: 20833550
    [Abstract] [Full Text] [Related]

  • 20. Synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl-D- and -L-furanosyl nucleosides.
    Chen X, Zhou W, Schinazi RF, Chu CK.
    J Org Chem; 2004 Sep 03; 69(18):6034-41. PubMed ID: 15373488
    [Abstract] [Full Text] [Related]

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