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Journal Abstract Search

211 related items for PubMed ID: 15916445

  • 1. 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone as a potent and orally active cyclooxygenase-2 selective inhibitor: synthesis and biological evaluation.
    Khanapure SP, Augustyniak ME, Earl RA, Garvey DS, Letts LG, Martino AM, Murty MG, Schwalb DJ, Shumway MJ, Trocha AM, Young DV, Zemtseva IS, Janero DR.
    J Med Chem; 2005 Jun 02; 48(11):3930-4. PubMed ID: 15916445
    [Abstract] [Full Text] [Related]

  • 2. Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors.
    Campbell JA, Bordunov V, Broka CA, Browner MF, Kress JM, Mirzadegan T, Ramesha C, Sanpablo BF, Stabler R, Takahara P, Villasenor A, Walker KA, Wang JH, Welch M, Weller P.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4741-5. PubMed ID: 15324899
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
    Song Y, Connor DT, Sercel AD, Sorenson RJ, Doubleday R, Unangst PC, Roth BD, Beylin VG, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD.
    J Med Chem; 1999 Apr 08; 42(7):1161-9. PubMed ID: 10197960
    [Abstract] [Full Text] [Related]

  • 4. 2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.
    Black WC, Brideau C, Chan CC, Charleson S, Chauret N, Claveau D, Ethier D, Gordon R, Greig G, Guay J, Hughes G, Jolicoeur P, Leblanc Y, Nicoll-Griffith D, Ouimet N, Riendeau D, Visco D, Wang Z, Xu L, Prasit P.
    J Med Chem; 1999 Apr 08; 42(7):1274-81. PubMed ID: 10197970
    [Abstract] [Full Text] [Related]

  • 5. ABT-963 [2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], a highly potent and selective disubstituted pyridazinone cyclooxgenase-2 inhibitor.
    Harris RR, Black L, Surapaneni S, Kolasa T, Majest S, Namovic MT, Grayson G, Komater V, Wilcox D, King L, Marsh K, Jarvis MF, Nuss M, Nellans H, Pruesser L, Reinhart GA, Cox B, Jacobson P, Stewart A, Coghlan M, Carter G, Bell RL.
    J Pharmacol Exp Ther; 2004 Dec 08; 311(3):904-12. PubMed ID: 15277581
    [Abstract] [Full Text] [Related]

  • 6. Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
    Song Y, Connor DT, Doubleday R, Sorenson RJ, Sercel AD, Unangst PC, Roth BD, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD.
    J Med Chem; 1999 Apr 08; 42(7):1151-60. PubMed ID: 10197959
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
    Praveen Rao PN, Amini M, Li H, Habeeb AG, Knaus EE.
    J Med Chem; 2003 Nov 06; 46(23):4872-82. PubMed ID: 14584938
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors.
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2005 Aug 01; 13(15):4694-703. PubMed ID: 15914011
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and structure-activity relationship of novel, highly potent metharyl and methcycloalkyl cyclooxygenase-2 (COX-2) selective inhibitors.
    Khanapure SP, Garvey DS, Young DV, Ezawa M, Earl RA, Gaston RD, Fang X, Murty M, Martino A, Shumway M, Trocha M, Marek P, Tam SW, Janero DR, Letts LG.
    J Med Chem; 2003 Dec 04; 46(25):5484-504. PubMed ID: 14640557
    [Abstract] [Full Text] [Related]

  • 10. 2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors.
    Dubé D, Brideau C, Deschênes D, Fortin R, Friesen RW, Gordon R, Girard Y, Riendeau D, Savoie C, Chan CC.
    Bioorg Med Chem Lett; 1999 Jun 21; 9(12):1715-20. PubMed ID: 10397507
    [Abstract] [Full Text] [Related]

  • 11. Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
    Li JJ, Norton MB, Reinhard EJ, Anderson GD, Gregory SA, Isakson PC, Koboldt CM, Masferrer JL, Perkins WE, Seibert K, Zhang Y, Zweifel BS, Reitz DB.
    J Med Chem; 1996 Apr 26; 39(9):1846-56. PubMed ID: 8627608
    [Abstract] [Full Text] [Related]

  • 12. 1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.
    Khanna IK, Weier RM, Yu Y, Xu XD, Koszyk FJ, Collins PW, Koboldt CM, Veenhuizen AW, Perkins WE, Casler JJ, Masferrer JL, Zhang YY, Gregory SA, Seibert K, Isakson PC.
    J Med Chem; 1997 May 23; 40(11):1634-47. PubMed ID: 9171873
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.
    Rao PN, Uddin MJ, Knaus EE.
    J Med Chem; 2004 Jul 29; 47(16):3972-90. PubMed ID: 15267236
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.
    Velázquez C, Rao PN, McDonald R, Knaus EE.
    Bioorg Med Chem; 2005 Apr 15; 13(8):2749-57. PubMed ID: 15781386
    [Abstract] [Full Text] [Related]

  • 15. In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives.
    Shin SS, Byun Y, Lim KM, Choi JK, Lee KW, Moh JH, Kim JK, Jeong YS, Kim JY, Choi YH, Koh HJ, Park YH, Oh YI, Noh MS, Chung S.
    J Med Chem; 2004 Feb 12; 47(4):792-804. PubMed ID: 14761182
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7898-909. PubMed ID: 16904331
    [Abstract] [Full Text] [Related]

  • 17. Design and synthesis of acyclic triaryl (Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors.
    Uddin MJ, Rao PN, Knaus EE.
    Bioorg Med Chem; 2004 Nov 15; 12(22):5929-40. PubMed ID: 15498669
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis, and biological evaluation of (E)- and (Z)-styryl-2-acetoxyphenyl sulfides and sulfones as cyclooxygenase-2 inhibitors.
    Reddy MV, Mallireddigari MR, Pallela VR, Venkatapuram P, Boominathan R, Bell SC, Reddy EP.
    Bioorg Med Chem; 2005 Mar 01; 13(5):1715-23. PubMed ID: 15698789
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
    Almansa C, Alfón J, de Arriba AF, Cavalcanti FL, Escamilla I, Gómez LA, Miralles A, Soliva R, Bartrolí J, Carceller E, Merlos M, García-Rafanell J.
    J Med Chem; 2003 Jul 31; 46(16):3463-75. PubMed ID: 12877584
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazoles.
    Ranatunge RR, Augustyniak M, Bandarage UK, Earl RA, Ellis JL, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Schroeder JD, Shumway MJ, Tam SW, Trocha AM, Young DV.
    J Med Chem; 2004 Apr 22; 47(9):2180-93. PubMed ID: 15084117
    [Abstract] [Full Text] [Related]

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