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Journal Abstract Search

89 related items for PubMed ID: 15937403

  • 1. Cytoprotective effect of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) against ischemia/reperfusion-induced injury in rat heart involves inhibition of fodrin breakdown and protein tyrosine nitration.
    Hashimoto M, Takada Y, Takeuchi Y, Kasahara J, Hisa H, Shirasaki Y, Fukunaga K.
    J Pharmacol Sci; 2005 Jun; 98(2):142-50. PubMed ID: 15937403
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  • 2. DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart.
    Fukunaga K, Han F, Shioda N, Moriguchi S, Kasahara J, Shirasaki Y.
    Cardiovasc Drug Rev; 2006 Jun; 24(2):88-100. PubMed ID: 16961723
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  • 3. Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice.
    Han F, Lu YM, Hasegawa H, Kanai H, Hachimura E, Shirasaki Y, Fukunaga K.
    J Pharmacol Exp Ther; 2010 Feb; 332(2):421-8. PubMed ID: 19889795
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  • 8. The post-ischemic administration of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, prevents delayed neuronal death in gerbil hippocampus.
    Hashiguchi A, Yano S, Morioka M, Hamada J, Shirasaki Y, Kochi M, Fukunaga K.
    J Pharmacol Sci; 2004 Sep; 96(1):65-72. PubMed ID: 15359085
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  • 9. Post-ischemic administration of DY-9760e, a novel calmodulin antagonist, reduced infarct volume in the permanent focal ischemia model of spontaneously hypertensive rat.
    Takagi K, Sato T, Shirasaki Y, Narita K, Tamura A, Sano K.
    Neurol Res; 2001 Sep; 23(6):662-8. PubMed ID: 11547940
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  • 10. Inhibition of neuronal nitric oxide synthase activity by 3-[2-[4-(3-chloro-2-methylphenyl)- 1-piperazinyl]ethyl]-5, 6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel neuroprotective agent, in vitro and in cultured neuroblastoma cells in situ.
    Fukunaga K, Ohmitsu M, Miyamoto E, Sato T, Sugimura M, Uchida T, Shirasaki Y.
    Biochem Pharmacol; 2000 Sep 01; 60(5):693-9. PubMed ID: 10927028
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  • 11. DY-9760e, a calmodulin antagonist, reduces brain damage after permanent focal cerebral ischemia in cats.
    Sugimura M, Takamori H, Fukushi H, Kitano Y, Kanazawa Y, Shirasaki Y.
    Biol Pharm Bull; 2005 Apr 01; 28(4):629-33. PubMed ID: 15802800
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  • 14. DY-9760e, a novel calmodulin antagonist, reduces infarction after permanent focal cerebral ischemia in rats.
    Sato T, Takamori H, Shirasaki Y.
    Pharmacology; 2004 May 01; 71(1):38-45. PubMed ID: 15051921
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  • 15. Determination of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1- (4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, DY-9760e, in human plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection.
    Tachibana S, Fukano A, Sudo K, Tanaka M.
    J Chromatogr B Biomed Sci Appl; 1999 Oct 29; 734(1):39-45. PubMed ID: 10574188
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  • 17. Pharmacokinetics and disposition of DY-9760e, a novel calmodulin antagonist, in rats and monkeys.
    Tachibana S, Fujimaki Y, Tachibana M, Tanaka M, Kurata T, Okazaki O, Sudo K.
    Arzneimittelforschung; 2005 Oct 29; 55(3):135-44. PubMed ID: 15819385
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