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Journal Abstract Search

171 related items for PubMed ID: 15958191

  • 1. Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
    Pietrak BL, Crouthamel MC, Tugusheva K, Lineberger JE, Xu M, DiMuzio JM, Steele T, Espeseth AS, Stachel SJ, Coburn CA, Graham SL, Vacca JP, Shi XP, Simon AJ, Hazuda DJ, Lai MT.
    Anal Biochem; 2005 Jul 01; 342(1):144-51. PubMed ID: 15958191
    [Abstract] [Full Text] [Related]

  • 2. Development and characterization of beta-secretase monolithic micro-immobilized enzyme reactor for on-line high-performance liquid chromatography studies.
    Mancini F, Naldi M, Cavrini V, Andrisano V.
    J Chromatogr A; 2007 Dec 21; 1175(2):217-26. PubMed ID: 17991476
    [Abstract] [Full Text] [Related]

  • 3. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb 21; 100(3):802-9. PubMed ID: 17156133
    [Abstract] [Full Text] [Related]

  • 4. Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.
    Kinoshita A, Fukumoto H, Shah T, Whelan CM, Irizarry MC, Hyman BT.
    J Cell Sci; 2003 Aug 15; 116(Pt 16):3339-46. PubMed ID: 12829747
    [Abstract] [Full Text] [Related]

  • 5. Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects.
    Wu G, Sankaranarayanan S, Tugusheva K, Kahana J, Seabrook G, Shi XP, King E, Devanarayan V, Cook JJ, Simon AJ.
    Clin Biochem; 2008 Aug 15; 41(12):986-96. PubMed ID: 18489907
    [Abstract] [Full Text] [Related]

  • 6. Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s).
    Schechter I, Ziv E.
    Biol Chem; 2008 Mar 15; 389(3):313-20. PubMed ID: 18177262
    [Abstract] [Full Text] [Related]

  • 7. A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation.
    Tanahashi H, Tabira T.
    Neurosci Lett; 2007 Nov 27; 428(2-3):103-8. PubMed ID: 17961921
    [Abstract] [Full Text] [Related]

  • 8. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
    Asai M, Hattori C, Iwata N, Saido TC, Sasagawa N, Szabó B, Hashimoto Y, Maruyama K, Tanuma S, Kiso Y, Ishiura S.
    J Neurochem; 2006 Jan 27; 96(2):533-40. PubMed ID: 16336629
    [Abstract] [Full Text] [Related]

  • 9. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.
    J Pharmacol Exp Ther; 2009 Nov 27; 331(2):598-608. PubMed ID: 19671883
    [Abstract] [Full Text] [Related]

  • 10. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.
    J Pharmacol Exp Ther; 2008 Mar 27; 324(3):957-69. PubMed ID: 18156464
    [Abstract] [Full Text] [Related]

  • 11. Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
    Yang W, Lu W, Lu Y, Zhong M, Sun J, Thomas AE, Wilkinson JM, Fucini RV, Lam M, Randal M, Shi XP, Jacobs JW, McDowell RS, Gordon EM, Ballinger MD.
    J Med Chem; 2006 Feb 09; 49(3):839-42. PubMed ID: 16451048
    [Abstract] [Full Text] [Related]

  • 12. Progress toward the discovery and development of efficacious BACE inhibitors.
    Durham TB, Shepherd TA.
    Curr Opin Drug Discov Devel; 2006 Nov 09; 9(6):776-91. PubMed ID: 17117686
    [Abstract] [Full Text] [Related]

  • 13. Effects of peptides derived from BACE1 catalytic domain on APP processing.
    Yeon SW, Jeon YJ, Hwang EM, Kim TY.
    Peptides; 2007 Apr 09; 28(4):838-44. PubMed ID: 17293005
    [Abstract] [Full Text] [Related]

  • 14. Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
    Stachel SJ, Coburn CA, Steele TG, Jones KG, Loutzenhiser EF, Gregro AR, Rajapakse HA, Lai MT, Crouthamel MC, Xu M, Tugusheva K, Lineberger JE, Pietrak BL, Espeseth AS, Shi XP, Chen-Dodson E, Holloway MK, Munshi S, Simon AJ, Kuo L, Vacca JP.
    J Med Chem; 2004 Dec 16; 47(26):6447-50. PubMed ID: 15588077
    [Abstract] [Full Text] [Related]

  • 15. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
    Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.
    J Pharmacol Exp Ther; 2008 Aug 16; 326(2):502-13. PubMed ID: 18499745
    [Abstract] [Full Text] [Related]

  • 16. Expression, purification and activity measurement of soluble BACE protein in E.coli.
    Wei XC, Li H, Ji JG, Li R, Ren YF, Feng JH, Hao FY.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai); 2002 Jul 16; 34(4):498-501. PubMed ID: 12098775
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
    Na CH, Jeon SH, Zhang G, Olson GL, Chae CB.
    J Neurochem; 2007 Jun 16; 101(6):1583-95. PubMed ID: 17542811
    [Abstract] [Full Text] [Related]

  • 18. Characterization of recombinant, soluble beta-secretase from an insect cell expression system.
    Mallender WD, Yager D, Onstead L, Nichols MR, Eckman C, Sambamurti K, Kopcho LM, Marcinkeviciene J, Copeland RA, Rosenberry TL.
    Mol Pharmacol; 2001 Mar 16; 59(3):619-26. PubMed ID: 11179458
    [Abstract] [Full Text] [Related]

  • 19. An inhibitor binding pocket distinct from the catalytic active site on human beta-APP cleaving enzyme.
    Kornacker MG, Lai Z, Witmer M, Ma J, Hendrick J, Lee VG, Riexinger DJ, Mapelli C, Metzler W, Copeland RA.
    Biochemistry; 2005 Aug 30; 44(34):11567-73. PubMed ID: 16114893
    [Abstract] [Full Text] [Related]

  • 20. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep 30; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

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