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143 related items for PubMed ID: 1596289

  • 1. Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.
    Ward WH, Kimbell R, Jackman AL.
    Biochem Pharmacol; 1992 May 08; 43(9):2029-31. PubMed ID: 1596289
    [Abstract] [Full Text] [Related]

  • 2. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
    Jackman AL, Taylor GA, Gibson W, Kimbell R, Brown M, Calvert AH, Judson IR, Hughes LR.
    Cancer Res; 1991 Oct 15; 51(20):5579-86. PubMed ID: 1913676
    [Abstract] [Full Text] [Related]

  • 3. The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells.
    Gibson W, Bisset GM, Marsham PR, Kelland LR, Judson IR, Jackman AL.
    Biochem Pharmacol; 1993 Feb 24; 45(4):863-9. PubMed ID: 7680860
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  • 9. Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.
    Rathod PK, Reshmi S.
    Antimicrob Agents Chemother; 1994 Mar 24; 38(3):476-80. PubMed ID: 8203840
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  • 10. Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.
    Lu K, Yin MB, McGuire JJ, Bonmassar E, Rustum YM.
    Biochem Pharmacol; 1995 Jul 31; 50(3):391-8. PubMed ID: 7646540
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  • 11. 5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.
    Chong LK, Tattersall MH.
    Biochem Pharmacol; 1995 Mar 15; 49(6):819-27. PubMed ID: 7702640
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  • 12. Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.
    Pressacco J, Mitrovski B, Erlichman C, Hedley DW.
    Cancer Res; 1995 Apr 01; 55(7):1505-8. PubMed ID: 7882359
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  • 13. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
    Aherne GW, Hardcastle A, Raynaud F, Jackman AL.
    Biochem Pharmacol; 1996 May 17; 51(10):1293-301. PubMed ID: 8787544
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  • 14. Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.
    Bisset GM, Pawelczak K, Jackman AL, Calvert AH, Hughes LR.
    J Med Chem; 1992 Mar 06; 35(5):859-66. PubMed ID: 1372358
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  • 15. ICI D1694, an inhibitor of thymidylate synthase for clinical study.
    Jackman AL, Jodrell DI, Gibson W, Stephens TC.
    Adv Exp Med Biol; 1991 Mar 06; 309A():19-23. PubMed ID: 1789205
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  • 16. Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates.
    Jackman AL, Marsham PR, Moran RG, Kimbell R, O'Connor BM, Hughes LR, Calvert AH.
    Adv Enzyme Regul; 1991 Mar 06; 31():13-27. PubMed ID: 1877386
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  • 17. Combination studies with 3'-azido-3'-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects.
    Pressacco J, Erlichman C.
    Biochem Pharmacol; 1993 Dec 03; 46(11):1989-97. PubMed ID: 8267649
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  • 18. The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats.
    Jodrell DI, Newell DR, Gibson W, Hughes LR, Calvert AH.
    Cancer Chemother Pharmacol; 1991 Dec 03; 28(5):331-8. PubMed ID: 1914075
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  • 19. Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
    Li WW, Tong WP, Bertino JR.
    Clin Cancer Res; 1995 Jun 03; 1(6):631-6. PubMed ID: 9816025
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  • 20. Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays.
    Schöber C, Gibbs JF, Yin MB, Slocum HK, Rustum YM.
    Biochem Pharmacol; 1994 Aug 30; 48(5):997-1002. PubMed ID: 8093112
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