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Journal Abstract Search

178 related items for PubMed ID: 15979874

  • 1. Discodermolide analogues as the chemical component of combination bacteriolytic therapy.
    Smith AB, Freeze BS, LaMarche MJ, Sager J, Kinzler KW, Vogelstein B.
    Bioorg Med Chem Lett; 2005 Aug 01; 15(15):3623-6. PubMed ID: 15979874
    [Abstract] [Full Text] [Related]

  • 2. Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity.
    Gunasekera SP, Mickel SJ, Daeffler R, Niederer D, Wright AE, Linley P, Pitts T.
    J Nat Prod; 2004 May 01; 67(5):749-56. PubMed ID: 15165132
    [Abstract] [Full Text] [Related]

  • 3. Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide.
    Harried SS, Lee CP, Yang G, Lee TI, Myles DC.
    J Org Chem; 2003 Aug 22; 68(17):6646-60. PubMed ID: 12919029
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide.
    Smith AB, Freeze BS, Lamarche MJ, Hirose T, Brouard I, Rucker PV, Xian M, Sundermann KF, Shaw SJ, Burlingame MA, Horwitz SB, Myles DC.
    Org Lett; 2005 Jan 20; 7(2):311-4. PubMed ID: 15646985
    [Abstract] [Full Text] [Related]

  • 5. Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity.
    Gunasekera SP, Longley RE, Isbrucker RA.
    J Nat Prod; 2002 Dec 20; 65(12):1830-7. PubMed ID: 12502323
    [Abstract] [Full Text] [Related]

  • 6. Toward understanding how the lactone moiety of discodermolide affects activity.
    Shaw SJ, Sundermann KF, Burlingame MA, Myles DC, Freeze BS, Xian M, Brouard I, Smith AB.
    J Am Chem Soc; 2005 May 11; 127(18):6532-3. PubMed ID: 15869264
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues.
    Burlingame MA, Shaw SJ, Sundermann KF, Zhang D, Petryka J, Mendoza E, Liu F, Myles DC, LaMarche MJ, Hirose T, Scott Freeze B, Smith AB.
    Bioorg Med Chem Lett; 2004 May 03; 14(9):2335-8. PubMed ID: 15081036
    [Abstract] [Full Text] [Related]

  • 8. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells.
    Honore S, Kamath K, Braguer D, Horwitz SB, Wilson L, Briand C, Jordan MA.
    Cancer Res; 2004 Jul 15; 64(14):4957-64. PubMed ID: 15256469
    [Abstract] [Full Text] [Related]

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  • 10. Design, synthesis, and biological evaluation of simplified analogues of (+)-discodermolide. Additional insights on the importance of the diene, the C7 hydroxyl, and the lactone.
    Smith AB, Xian M.
    Org Lett; 2005 Nov 10; 7(23):5229-32. PubMed ID: 16268545
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  • 12. Discodermolide: just another microtubule-stabilizing agent? No! A lesson in synergy.
    Giannakakou P, Fojo T.
    Clin Cancer Res; 2000 May 10; 6(5):1613-5. PubMed ID: 10815877
    [No Abstract] [Full Text] [Related]

  • 13. Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents.
    Choy N, Shin Y, Nguyen PQ, Curran DP, Balachandran R, Madiraju C, Day BW.
    J Med Chem; 2003 Jul 03; 46(14):2846-64. PubMed ID: 12825928
    [Abstract] [Full Text] [Related]

  • 14. Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin.
    Florence GJ, Gardner NM, Paterson I.
    Nat Prod Rep; 2008 Apr 03; 25(2):342-75. PubMed ID: 18389141
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  • 16. Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.
    Paterson I, Gardner NM, Guzmán E, Wright AE.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6268-72. PubMed ID: 18951787
    [Abstract] [Full Text] [Related]

  • 17. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
    Kowalski RJ, Giannakakou P, Gunasekera SP, Longley RE, Day BW, Hamel E.
    Mol Pharmacol; 1997 Oct 01; 52(4):613-22. PubMed ID: 9380024
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  • 19. Design, total synthesis, and evaluation of C13-C14 cyclopropane analogues of (+)-discodermolide.
    Smith AB, Xian M, Liu F.
    Org Lett; 2005 Oct 13; 7(21):4613-6. PubMed ID: 16209492
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