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267 related items for PubMed ID: 15987690

  • 1. Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.
    Sulton D, Pagan-Rodriguez D, Zhou X, Liu Y, Hujer AM, Bethel CR, Helfand MS, Thomson JM, Anderson VE, Buynak JD, Ng LM, Bonomo RA.
    J Biol Chem; 2005 Oct 21; 280(42):35528-36. PubMed ID: 15987690
    [Abstract] [Full Text] [Related]

  • 2. Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
    Helfand MS, Bethel CR, Hujer AM, Hujer KM, Anderson VE, Bonomo RA.
    J Biol Chem; 2003 Dec 26; 278(52):52724-9. PubMed ID: 14534312
    [Abstract] [Full Text] [Related]

  • 3. Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
    Helfand MS, Taracila MA, Totir MA, Bonomo RA, Buynak JD, van den Akker F, Carey PR.
    Biochemistry; 2007 Jul 24; 46(29):8689-99. PubMed ID: 17595114
    [Abstract] [Full Text] [Related]

  • 4. Tazobactam inactivation of SHV-1 and the inhibitor-resistant Ser130 -->Gly SHV-1 beta-lactamase: insights into the mechanism of inhibition.
    Pagan-Rodriguez D, Zhou X, Simmons R, Bethel CR, Hujer AM, Helfand MS, Jin Z, Guo B, Anderson VE, Ng LM, Bonomo RA.
    J Biol Chem; 2004 May 07; 279(19):19494-501. PubMed ID: 14757767
    [Abstract] [Full Text] [Related]

  • 5. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244.
    Thomson JM, Distler AM, Bonomo RA.
    Biochemistry; 2007 Oct 09; 46(40):11361-8. PubMed ID: 17848099
    [Abstract] [Full Text] [Related]

  • 6. Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.
    Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA.
    Antimicrob Agents Chemother; 2011 Jul 09; 55(7):3465-75. PubMed ID: 21555770
    [Abstract] [Full Text] [Related]

  • 7. The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.
    Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA.
    Biochemistry; 2009 Jun 02; 48(21):4557-66. PubMed ID: 19351161
    [Abstract] [Full Text] [Related]

  • 8. Avibactam and inhibitor-resistant SHV β-lactamases.
    Winkler ML, Papp-Wallace KM, Taracila MA, Bonomo RA.
    Antimicrob Agents Chemother; 2015 Jul 02; 59(7):3700-9. PubMed ID: 25691639
    [Abstract] [Full Text] [Related]

  • 9. Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance.
    Thomson JM, Distler AM, Prati F, Bonomo RA.
    J Biol Chem; 2006 Sep 08; 281(36):26734-44. PubMed ID: 16803899
    [Abstract] [Full Text] [Related]

  • 10. Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.
    Brown RP, Aplin RT, Schofield CJ.
    Biochemistry; 1996 Sep 24; 35(38):12421-32. PubMed ID: 8823177
    [Abstract] [Full Text] [Related]

  • 11. Variants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.
    Papp-Wallace KM, Winkler ML, Taracila MA, Bonomo RA.
    Antimicrob Agents Chemother; 2015 Jul 24; 59(7):3710-7. PubMed ID: 25666153
    [Abstract] [Full Text] [Related]

  • 12. Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases.
    Giakkoupi P, Tzelepi E, Legakis NJ, Tzouvelekis LS.
    J Antimicrob Chemother; 1999 Jan 24; 43(1):23-9. PubMed ID: 10381097
    [Abstract] [Full Text] [Related]

  • 13. Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase.
    Winkler ML, Rodkey EA, Taracila MA, Drawz SM, Bethel CR, Papp-Wallace KM, Smith KM, Xu Y, Dwulit-Smith JR, Romagnoli C, Caselli E, Prati F, van den Akker F, Bonomo RA.
    J Med Chem; 2013 Feb 14; 56(3):1084-97. PubMed ID: 23252553
    [Abstract] [Full Text] [Related]

  • 14. Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme.
    Manageiro V, Ferreira E, Cougnoux A, Albuquerque L, Caniça M, Bonnet R.
    Antimicrob Agents Chemother; 2012 Feb 14; 56(2):1042-6. PubMed ID: 22083476
    [Abstract] [Full Text] [Related]

  • 15. Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance.
    Li M, Conklin BC, Taracila MA, Hutton RA, Skalweit MJ.
    Antimicrob Agents Chemother; 2012 Nov 14; 56(11):5678-86. PubMed ID: 22908166
    [Abstract] [Full Text] [Related]

  • 16. X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid.
    Swarén P, Golemi D, Cabantous S, Bulychev A, Maveyraud L, Mobashery S, Samama JP.
    Biochemistry; 1999 Jul 27; 38(30):9570-6. PubMed ID: 10423234
    [Abstract] [Full Text] [Related]

  • 17. Importance of position 170 in the inhibition of GES-type β-lactamases by clavulanic acid.
    Frase H, Toth M, Champion MM, Antunes NT, Vakulenko SB.
    Antimicrob Agents Chemother; 2011 Apr 27; 55(4):1556-62. PubMed ID: 21220532
    [Abstract] [Full Text] [Related]

  • 18. Substitution of Met-69 by Ala or Gly in TEM-1 beta-lactamase confer an increased susceptibility to clavulanic acid and other inhibitors.
    Madec S, Blin C, Krishnamoorthy R, Picard B, Chaibi el B, Fouchereau-Péron M, Labia R.
    FEMS Microbiol Lett; 2002 May 21; 211(1):13-6. PubMed ID: 12052544
    [Abstract] [Full Text] [Related]

  • 19. Understanding the molecular determinants of substrate and inhibitor specificities in the Carbapenemase KPC-2: exploring the roles of Arg220 and Glu276.
    Papp-Wallace KM, Taracila MA, Smith KM, Xu Y, Bonomo RA.
    Antimicrob Agents Chemother; 2012 Aug 21; 56(8):4428-38. PubMed ID: 22687511
    [Abstract] [Full Text] [Related]

  • 20. Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.
    Vakulenko SB, Geryk B, Kotra LP, Mobashery S, Lerner SA.
    Antimicrob Agents Chemother; 1998 Jul 21; 42(7):1542-8. PubMed ID: 9660980
    [Abstract] [Full Text] [Related]

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