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Journal Abstract Search

205 related items for PubMed ID: 15987904

  • 1. Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs.
    Oikonomakos NG, Kosmopoulou MN, Chrysina ED, Leonidas DD, Kostas ID, Wendt KU, Klabunde T, Defossa E.
    Protein Sci; 2005 Jul; 14(7):1760-71. PubMed ID: 15987904
    [Abstract] [Full Text] [Related]

  • 2. Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
    Klabunde T, Wendt KU, Kadereit D, Brachvogel V, Burger HJ, Herling AW, Oikonomakos NG, Kosmopoulou MN, Schmoll D, Sarubbi E, von Roedern E, Schönafinger K, Defossa E.
    J Med Chem; 2005 Oct 06; 48(20):6178-93. PubMed ID: 16190745
    [Abstract] [Full Text] [Related]

  • 3. FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase.
    Tiraidis C, Alexacou KM, Zographos SE, Leonidas DD, Gimisis T, Oikonomakos NG.
    Protein Sci; 2007 Aug 06; 16(8):1773-82. PubMed ID: 17600143
    [Abstract] [Full Text] [Related]

  • 4. Modeling aided design of potent glycogen phosphorylase inhibitors.
    Deng Q, Lu Z, Bohn J, Ellsworth KP, Myers RW, Geissler WM, Harris G, Willoughby CA, Chapman K, McKeever B, Mosley R.
    J Mol Graph Model; 2005 Apr 06; 23(5):457-64. PubMed ID: 15781188
    [Abstract] [Full Text] [Related]

  • 5. The 1.76 A resolution crystal structure of glycogen phosphorylase B complexed with glucose, and CP320626, a potential antidiabetic drug.
    Oikonomakos NG, Zographos SE, Skamnaki VT, Archontis G.
    Bioorg Med Chem; 2002 May 06; 10(5):1313-9. PubMed ID: 11886794
    [Abstract] [Full Text] [Related]

  • 6. N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
    Nagy V, Felföldi N, Kónya B, Praly JP, Docsa T, Gergely P, Chrysina ED, Tiraidis C, Kosmopoulou MN, Alexacou KM, Konstantakaki M, Leonidas DD, Zographos SE, Oikonomakos NG, Kozmon S, Tvaroška I, Somsák L.
    Bioorg Med Chem; 2012 Mar 01; 20(5):1801-16. PubMed ID: 22325154
    [Abstract] [Full Text] [Related]

  • 7. Kinetic analysis and modelling of the allosteric behaviour of liver and muscle glycogen phosphorylases.
    Cuadri-Tomé C, Barón C, Jara-Pérez V, Parody-Morreale A, Martinez JC, Cámara-Artigas A.
    J Mol Recognit; 2006 Mar 01; 19(5):451-7. PubMed ID: 16691548
    [Abstract] [Full Text] [Related]

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  • 10. Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol.
    Tsitsanou KE, Hayes JM, Keramioti M, Mamais M, Oikonomakos NG, Kato A, Leonidas DD, Zographos SE.
    Food Chem Toxicol; 2013 Nov 01; 61():14-27. PubMed ID: 23279842
    [Abstract] [Full Text] [Related]

  • 11. Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
    Wen X, Sun H, Liu J, Cheng K, Zhang P, Zhang L, Hao J, Zhang L, Ni P, Zographos SE, Leonidas DD, Alexacou KM, Gimisis T, Hayes JM, Oikonomakos NG.
    J Med Chem; 2008 Jun 26; 51(12):3540-54. PubMed ID: 18517260
    [Abstract] [Full Text] [Related]

  • 12. Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B.
    Oikonomakos NG, Skamnaki VT, Osz E, Szilágyi L, Somsák L, Docsa T, Tóth B, Gergely P.
    Bioorg Med Chem; 2002 Feb 26; 10(2):261-8. PubMed ID: 11741774
    [Abstract] [Full Text] [Related]

  • 13. Synthesis of a C-glucosylated cyclopropylamide and evaluation as a glycogen phosphorylase inhibitor.
    Bertus P, Szymoniak J, Jeanneau E, Docsa T, Gergely P, Praly JP, Vidal S.
    Bioorg Med Chem Lett; 2008 Sep 01; 18(17):4774-8. PubMed ID: 18701279
    [Abstract] [Full Text] [Related]

  • 14. The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors.
    Alexacou KM, Tenchiu Deleanu AC, Chrysina ED, Charavgi MD, Kostas ID, Zographos SE, Oikonomakos NG, Leonidas DD.
    Bioorg Med Chem; 2010 Nov 15; 18(22):7911-22. PubMed ID: 20947361
    [Abstract] [Full Text] [Related]

  • 15. Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.
    Oikonomakos NG, Tsitsanou KE, Zographos SE, Skamnaki VT, Goldmann S, Bischoff H.
    Protein Sci; 1999 Oct 15; 8(10):1930-45. PubMed ID: 10548038
    [Abstract] [Full Text] [Related]

  • 16. The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: an intermediate conformation with T-state and R-state features.
    Lukacs CM, Oikonomakos NG, Crowther RL, Hong LN, Kammlott RU, Levin W, Li S, Liu CM, Lucas-McGady D, Pietranico S, Reik L.
    Proteins; 2006 Jun 01; 63(4):1123-6. PubMed ID: 16523484
    [No Abstract] [Full Text] [Related]

  • 17. Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods.
    Czifrák K, Páhi A, Deák S, Kiss-Szikszai A, Kövér KE, Docsa T, Gergely P, Alexacou KM, Papakonstantinou M, Leonidas DD, Zographos SE, Chrysina ED, Somsák L.
    Bioorg Med Chem; 2014 Aug 01; 22(15):4028-41. PubMed ID: 25009003
    [Abstract] [Full Text] [Related]

  • 18. Glycogen phosphorylase a inhibitors with a phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.
    Motoshima K, Ishikawa M, Sugita K, Hashimoto Y.
    Biol Pharm Bull; 2009 Sep 01; 32(9):1618-20. PubMed ID: 19721243
    [Abstract] [Full Text] [Related]

  • 19. Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
    Oikonomakos NG, Kosmopoulou M, Zographos SE, Leonidas DD, Chrysina ED, Somsák L, Nagy V, Praly JP, Docsa T, Tóth B, Gergely P.
    Eur J Biochem; 2002 Mar 01; 269(6):1684-96. PubMed ID: 11895439
    [Abstract] [Full Text] [Related]

  • 20. Advances in glycogen phosphorylase inhibitor design.
    Oikonomakos NG, Somsák L.
    Curr Opin Investig Drugs; 2008 Apr 01; 9(4):379-95. PubMed ID: 18393105
    [Abstract] [Full Text] [Related]

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