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1727 related items for PubMed ID: 15992373

  • 1. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 2. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
    Nature; 1999 Apr 08; 398(6727):513-7. PubMed ID: 10206644
    [Abstract] [Full Text] [Related]

  • 3. Mutations in APP have independent effects on Abeta and CTFgamma generation.
    Hecimovic S, Wang J, Dolios G, Martinez M, Wang R, Goate AM.
    Neurobiol Dis; 2004 Nov 08; 17(2):205-18. PubMed ID: 15474359
    [Abstract] [Full Text] [Related]

  • 4. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 08; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 5. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ.
    Neurobiol Dis; 2000 Dec 08; 7(6 Pt B):673-81. PubMed ID: 11114265
    [Abstract] [Full Text] [Related]

  • 6. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.
    Nature; 1999 Dec 02; 402(6761):533-7. PubMed ID: 10591213
    [Abstract] [Full Text] [Related]

  • 7. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L, Gan L, Yu GQ, Essrich C, Mucke L.
    J Neurochem; 2004 Dec 02; 91(6):1260-74. PubMed ID: 15584903
    [Abstract] [Full Text] [Related]

  • 8. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.
    Neurobiol Dis; 2005 Nov 02; 20(2):625-37. PubMed ID: 15936948
    [Abstract] [Full Text] [Related]

  • 9. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
    [Abstract] [Full Text] [Related]

  • 10. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 11. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.
    Nature; 2000 Jun 08; 405(6787):689-94. PubMed ID: 10864326
    [Abstract] [Full Text] [Related]

  • 12. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
    De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F.
    Nature; 1998 Jan 22; 391(6665):387-90. PubMed ID: 9450754
    [Abstract] [Full Text] [Related]

  • 13. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
    Hoke DE, Tan JL, Ilaya NT, Culvenor JG, Smith SJ, White AR, Masters CL, Evin GM.
    FEBS J; 2005 Nov 22; 272(21):5544-57. PubMed ID: 16262694
    [Abstract] [Full Text] [Related]

  • 14. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 22; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 15. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
    Siman R, Salidas S.
    Neuroscience; 2004 Jan 22; 129(3):615-28. PubMed ID: 15541883
    [Abstract] [Full Text] [Related]

  • 16. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V.
    Nature; 1999 Dec 02; 402(6761):537-40. PubMed ID: 10591214
    [Abstract] [Full Text] [Related]

  • 17. Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway.
    Lopez-Perez E, Seidah NG, Checler F.
    J Neurochem; 1999 Nov 02; 73(5):2056-62. PubMed ID: 10537065
    [Abstract] [Full Text] [Related]

  • 18. Alzheimer's disease. Molecular consequences of presenilin-1 mutation.
    Gandy S, Naslund J, Nordstedt C.
    Nature; 2001 Jun 07; 411(6838):654-6. PubMed ID: 11395757
    [Abstract] [Full Text] [Related]

  • 19. Generation of amyloid beta protein from a presenilin-1 and betaAPP complex.
    Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castaño EM, St George-Hyslop P, Shoji M.
    Biochem Biophys Res Commun; 2002 Mar 29; 292(2):571-8. PubMed ID: 11906199
    [Abstract] [Full Text] [Related]

  • 20. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
    Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ.
    Neurobiol Dis; 1998 Aug 29; 5(2):107-16. PubMed ID: 9746908
    [Abstract] [Full Text] [Related]

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