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Journal Abstract Search
108 related items for PubMed ID: 16023819
1. In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide. Lin CC, Wong BK, Burgey CS, Gibson CR, Singh R. J Pharm Biomed Anal; 2005 Oct 04; 39(5):1014-20. PubMed ID: 16023819 [Abstract] [Full Text] [Related]
2. Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins. Singh R, Silva Elipe MV, Pearson PG, Arison BH, Wong BK, White R, Yu X, Burgey CS, Lin JH, Baillie TA. Chem Res Toxicol; 2003 Feb 04; 16(2):198-207. PubMed ID: 12588191 [Abstract] [Full Text] [Related]
3. Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR. Subramanian R, Lin CC, Ho JZ, Pitzenberger SM, Silva-Elipe MV, Gibson CR, Braun MP, Yu X, Yergey JL, Singh R. Drug Metab Dispos; 2003 Nov 04; 31(11):1437-47. PubMed ID: 14570777 [Abstract] [Full Text] [Related]
4. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry. Erve JC, Vashishtha SC, DeMaio W, Talaat RE. Drug Metab Dispos; 2007 Jun 04; 35(6):908-16. PubMed ID: 17353349 [Abstract] [Full Text] [Related]
5. Metabolism and bioactivation of 3-methylindole by human liver microsomes. Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS. Chem Res Toxicol; 2007 Jan 04; 20(1):140-8. PubMed ID: 17226936 [Abstract] [Full Text] [Related]
6. CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance. Prakash C, Wang W, O'Connell T, Johnson KA. Drug Metab Dispos; 2008 Oct 04; 36(10):2093-103. PubMed ID: 18653741 [Abstract] [Full Text] [Related]
10. Metabolism of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): identification of an unusual N-acetylglucosamine conjugate in the cynomolgus monkey. Johnson BM, Kamath AV, Leet JE, Liu X, Bhide RS, Tejwani RW, Zhang Y, Qian L, Wei DD, Lombardo LJ, Shu YZ. Drug Metab Dispos; 2008 Dec 04; 36(12):2475-83. PubMed ID: 18787055 [Abstract] [Full Text] [Related]
11. Metabolism of olaquindox in rat liver microsomes: structural elucidation of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Liu Z, Huang L, Dai M, Chen D, Wang Y, Tao Y, Yuan Z. Rapid Commun Mass Spectrom; 2008 Apr 04; 22(7):1009-16. PubMed ID: 18320546 [Abstract] [Full Text] [Related]
15. Structural identification of imatinib cyanide adducts by mass spectrometry and elucidation of bioactivation pathway. Li AC, Yu E, Ring SC, Chovan JP. Rapid Commun Mass Spectrom; 2014 Jan 15; 28(1):123-34. PubMed ID: 24285397 [Abstract] [Full Text] [Related]
17. Identification of a novel in vitro metabonate from liver microsomal incubations. Li C, Surapaneni S, Zeng Q, Marquez B, Chow D, Kumar G. Drug Metab Dispos; 2006 Jun 15; 34(6):901-5. PubMed ID: 16554371 [Abstract] [Full Text] [Related]
18. A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry. Lim HK, Chen J, Cook K, Sensenhauser C, Silva J, Evans DC. Rapid Commun Mass Spectrom; 2008 Apr 15; 22(8):1295-311. PubMed ID: 18383206 [Abstract] [Full Text] [Related]
20. Biotransformation of 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878), a novel 5-hydroxytryptamine (5-HT)1A agonist/5-HT3 antagonist, in human hepatic cytochrome P450 enzymes. Minato K, Suzuki R, Asagarasu A, Matsui T, Sato M. Drug Metab Dispos; 2008 May 15; 36(5):831-40. PubMed ID: 18238859 [Abstract] [Full Text] [Related] Page: [Next] [New Search]